Lecture 4: Mitochondrial Respiratory Chain Flashcards
1
Q
what are the components of the electron chain complex
A
- complexes I, II, III and IV
- linking proteins ubiquinone (aka coenzyme Q) and cytochrome C
2
Q
what is ubiquinone
A
- lipid soluble
- benzoquinone
- with long isoprenoid tail
3
Q
what is complex I
A
NADH dehydrogenase
4
Q
what is complex II
A
succinate dehydrogenase
5
Q
what is complex III
A
ubiquinone: cytochrome c oxidoreductase
6
Q
what is complex IV
A
cytochrome oxidase
7
Q
which complexes are proton pumps and how many H+ ions do they pump
A
complex I: 4H+
complex III: 4H+
complex IV: 2H+
8
Q
what does adenine nucleoside translocase do
A
transports ADP into matrix and ATP out
9
Q
what inhibits adenine nucleoside translocase
A
atractyloside, a glycoside isolated from thistle
10
Q
what is a naturally occuring uncoupling protein and where is it found
A
- thermogenin
- in brown adipose tissue
- dissipates H+ as heat
11
Q
what is a pharmacological uncoupling protein
A
- DNP
- was initially used as a weight loss aid
- causes liver damage, respiratory acidosis and hyperthermia
