lecture 10-glycolosis Flashcards
glycolosis inputs and outputs
uses 2 ATP and 1 glucose -> 2 pyruvate, 2NADH, 4 ATP out (net gain of 2)
phosphorylates glucose into G6P
hexokinase (HK)
enzyme that phosphorylates things
kinase
phosphofructokinase (PFK)
adds phosphate to carbon 1 of F6P
cleaves 6 carbon sugar into two 3-carbon intermediates DHAP and G3P
aldolase
DHAP
One of the two intermediates created from the cleavage of a 6-carbon sugar, has to be modified in order to be used to generate pyruvate
G3P
one of the two intermediates created from the cleavage of a 6- carbon sugar, is able to be broken down to generate pyruvate
triose phosphate isomerase (TIM)
converts DHAP into G3P
glyceraldehyde-3-phosphate (GAPDH)
uses inorganic phosphate and NAD+ to make G3P into 1,3 BPG
phosphogylcerate kinase (PGK)
phosphorylates ADP to ATP using 1,3-BPG
phosphoglycerate mutase (PGM)
isomerizes 3PG to 2PG
enolase
dehydrates 2PG to PEP (phosphoenolpyruvate)
Phosphoenolpyruvate (PEP)
the product of the dehydration of 2PG using enolase
pyruvate kinase (PK)
takes the phosphate off of PEP and phosphorylates ADP to ATP
glucose
a six carbon carbohydrate