Lecture 10 - Eczema Flashcards

1
Q

Define atopic eczema

A

Chronic, relapsing and itchy skin condition

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2
Q

What causes atopic eczema?

A

No single cause but is triggered by stress, hormonal changes (women), exposure to pets, home dust mites, pollen and food allergens
Reduction in lipid barrier of the skin, leads to increased water loss and a tendency towards dry skin

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3
Q

What are the complications associated with atopic eczema?

A

Infection - bacterial infection with S,aureus - risk of herpes simplex and fungal infections
Psychosocial - distress, missed school days, self-image, sleep disturbances
Erythroderma - severe skin condition that can result in complications such as dehydration, HF, infection and death
Eye abnormalities - irritation of the conjunctiva

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4
Q

What is the treatment advice for mild eczema?

A

Avoid scratching, house dust mites, irritants and soaps, stress and diet
Prescribe generous amounts of emollients
Step up and consider a mild corticosteroid cream or ointment

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5
Q

What is the treatment for moderate eczema ?

A

Prescribe generous amounts of emollients
Intensive treatments are needed:
- moderate potent topical corticosteroids e.g. betamethasone validate 0.025% or clobetasone butyrate 0.05% and continued for 48 hours
for delicate areas of skin consider starting with a mild potency topical corticosteroid e.g hydrocortisone 1%
Topical antibiotics if infected (Max 2 weeks) - fusidic acid or mupirocin ointment if small areas or oral flucloxacillin

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6
Q

What is the treatment of severe eczema?

A

Prescribe intensive treatment until the flare is controlled
Prescribe generous amounts of emollients and advice frequent and liberal use
Prescribe a potent topical corticosteroid for inflamed areas (betamethasone valerate 0.1%)
For delicate areas of skin such as the face or flexures use a moderate potency corticosteroid
if itching is severe consider prescribing a sedating antihistamine
If there is severe extensive eczema causing psychological distress - consider prescribing a short course of oral corticosteroids

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7
Q

Give examples of eczema triggers

A

Diet
Irritants
Inhalants
Hormonal
Climate
Infections

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8
Q

Define psoriasis

A

Chronic, inflammatory disorder, multi-system disease with predominately skin ad joint manifestations
Characterised by scaly, itchy skin lesions which can be in the form of patches, papules or plagues

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9
Q

What are the causes of psoriasis?

A

Strep infection
Some drugs - lithium and NSAIDs, beta blockers
Sunlight
Trauma
Stress
Alcohol
Smoking
Climate change
Hormone changes
HIV/AIDs

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10
Q

Whats the treatment for plaque psoriasis?

A

Emollient
Potent topical corticosteroid applied once daily reviewed after 4 weeks no longer than 8 weeks treatment without a break
Vit D analogue applied once daily
2nd and 3rd line options are via a specialist

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11
Q

Define scalp psoriasis treatment

A

Potent topical corticosteroid
Consider treatment with a Vit D analogue alone if can’t you use a corticosteroid or in combination with a potent corticosteroid scalp application
coal tar preparations
2nd and 3rd line options via a specialist

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12
Q

Define face/flexural/genital psoriasis treatment

A

Emollient and short-term mild or moderate topical corticosteroid preparation (OD or BD for up to 2 weeks), only being used for 1-2 weeks each month
4 week break need between corticosteroid courses
2nd and 3rd line options via a specialist

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13
Q

Define guttate psoriasis treatment

A

if lesions widespread - refer urgently to a dermatologist
not widespread:
self limiting usually resolves in 3-4 months
no treatment can be option
or consider topical treatments

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14
Q

Define pustular psoriasis treatment

A

Generalised pustular psoriasis - refer for same day specialist assessment and treatment
Medical emergency and requires urgent hospital treatment
Localised to the hands and feet

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15
Q

Define erythrodermic psoriasis treatment

A

arrange for same-day specialist assessment and treatment
associated with several potentially life-threatening complications

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16
Q

Define nail psoriasis treatment

A

Keep nails short
avoid manicures of the cuticle
avoid fake nails
no treatment required if disease is mild
if severe refer to a specialist
nail disease responds poorly to topical treatment

17
Q

What is the mode of action of vit D preparations?

A

Bind to vitamin D receptors which inhibits keratinocyte proliferation and enhances keratinocyte differentiation - 6-8 week treatment needed for best results
should not be used in people with calcium

18
Q

What are the risks with long-term corticosteroid cream use?

A

Risk of serious adverse effects
Systemic adverse effects are RARE but include adrenal suppression that can result in symptoms that can result in symptoms of Cushing’s syndrome and growth retardation

19
Q

Name some of the specialist treatments

A

Topical Calcineurin Inhibitors
Tacrolimus
Pimecrolimus
Alitretinoin
Phototherapy
Oral cyclosporin and azathioprine
UV light therapy
Methotrexate