Lecture 10, drug development

Question 1

Binding pocket

Answer 1

A place (cavity, cleft, allosteric site) on the surface or in the interior of a protein that possesses suitable properties for binding a ligand.

Question 2

Pharmacopore

Answer 2

Concept: ensemble of steric and electronic features ensuring optimal interaction to block or activate specific target and its downstream function.

Question 3

Pharmacopore prediction

Answer 3

1. protein preperation
2. binding site detection
3. Pharmacophore feature generation
4. Pharmacophore feature selection
5. Aplication

Question 4

Target quality:

Answer 4

The certainty that the target can modify the disease

Question 5

Target tractability:

Answer 5

The likelyhood to identify modulator

Question 6

Druggability:

Answer 6

The chance of a protein to be able to bind to a drug with a therapeutic useful level of affinity, efficiency and safety