Lecture 10 Flashcards

1
Q

What has to happen to polarized structure for cytokinesis to occur

A

Depolymerize

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2
Q

What needs to happen to cell after division

A

Needs to go from nonpolar to polar to support function

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3
Q

Dense material left after cytokinesis is the

A

Midbody, leaves a marker on both cell

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4
Q

The midbody acts as

A

A landmark for polarization in new cells

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5
Q

Cell polarization-post cytokinesis

A

-Apical-basal polarity
-Cell-cell communication
-Cell migration

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6
Q

Apical-basal polarity (simple) and example

A

Molecules need to be transported in one direction -epithelial cells

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7
Q

Actin filaments bundle into _______ to _______

A

Microvilli, increase cell surface area - (these anchor on adherent junctions that anchors each cell to the next)

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8
Q

IFs anchor actin in the cell cortex with _________ that _____

A

desmosomes/hemidesmosomes, that connect cell w other cell and ECM

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9
Q

Microtubules polymerize from _____ to _________ for what?

A

Apical to basal, directionality for transport of intracellular components

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10
Q

In the polarized cell, actin filaments are

A

highly localized into filopodia and lamelopodia

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11
Q

Planar cell polarity

A

Orients polarity axis in relation to neighbours and basal lamina

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12
Q

2 key regulators of actin assembly and what do they bind to

A

Rac and Cdc42 - specific binding sites on Par3/6 and aPXC

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13
Q

Par3 and 6 are what type of proteins and what domain to they contain

A

Scaffold proteins, PDZ domains

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14
Q

What do PDZ domains do/give in the cell

A

Give localization within cell

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15
Q

CRB

A

transmembrane protein and tumor supprsssor active during transformation and progression of mammalian epi cells

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16
Q

Crumbsscomplex

A

CRB and PALS1 and PALS1-associated tight junction protein (PATJ)

17
Q

Scrib complex

A

SCRIB, lethal (2) giant larvae homologue (LGL), discs large homologue (DLG)

18
Q

LGL

A

cytoskeletal protein that can bind myosin II

19
Q

DLG

A

scaffold protein

20
Q

Mechanism of apical-basal polarity

A