Lecture 1 - Radiation Flashcards
Radioactivity describes what?
The decay rate of a radioactive material.
*Measured in Becquerels
What is exposure?
Measure of radioactive kinetic energy emitted from a source and is quantified generally by its capacity to ionize air. It’s a measure of the intensity of the radiation field.
*Measured in units of charge/mass - Coulombs/Kilogram (C/Kg)
What is the absorbed dose?
Energy absorbed by any type of matter, and is derived by calculating the imparted energy divided by the mass absorbing it.
*Measured in Gray (Gy)
What is the equivalent dose?
It is used to compare the biological effect on a tissue from diff types of radiation.
*Particulate radiation has high LET (linear energy transfer) than photons, and thus a greater biological effect. [Larger marbles have more mass and can potentially transfer more energy in a collision
**Measured in Sieverts (Sv)
What is the effective dose?
It is used to measure the estimated risk to humans.
*Takes into account the type of radiation (equivalent dose) and the nature of each organ or tissue being irradiated, so sums it up to get a whole body effective dose
**Measured in Sievert (Sv)
More ________ dividing, ______ differentiated cells are most susceptible and thus are more heavily weighted in calculating effective dose.
Rapidly
Less
What is the absorbed dose?
What is the equivalent dose?
What is the effective dose?
- Energy deposited in a kg of a substance by the radiation
- Absorbed dose weighted for harmful effects of different radiations
- Equivalent dose weighted for susceptibility to harm of different tissues (More sensitive the tissue is, the higher the effective dose)
What is radiobiology?
The study of the effects of ionizing radiation on living systems
What is a direct effect?
When a photon or secondary e- ionizes biological macromolecules
THIS ACCOUNTS FOR 1/3 OF BIOLOGIC DAMAGE FROM X-RAYS
T/F - Altered molecules differ structurally and functionally from originals, so this results in a biological change.
TRUE
*Can lead to cell death, mutation, or carcinogenesis
What is the radiolysis of water?
Photon absorbed by water in an organism, ionizing water molecules into free radicals
*photon + H2O = Hdot + OHdot
T/F - Ionization of H2O leads to free radical production.
TRUE
What is the indirect effect?
Free radicals and toxins produced thru the intermediate step of water radiolysis then interact with biological macromolecules to cause changes.
THIS ACCOUNTS FOR 2/3 OF BIOLOGICAL DAMAGE FROM X-RAYS
T/F - Organic free radicals are unstable and transform quickly to stable altered molecules
TRUE
What is the primary cause of radiation induced cell death?
Damage to DNA
Can result from:
Breakage of one or both DNA strands
Cross linking of DNA strands w/in helix to other DNA strands
Change or loss of base
Disruption of H-H bonds b/t DNA strands
What is the deterministic effect?
Radiation injury dependent on the dose
-The greater the dose, the greater the injury severity
High level of exposure is req’d to produce a clinically observable effect
There is an exposure threshold below which the effect does not occur or is clinically observable
Typically these effects are tissue related