Lecture 1: Intro to Neuroscience Flashcards

1
Q

What is the general function of our nervous system?

A
  • control
  • regulate
  • communicate
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2
Q

What are the components of the CNS?

A

brain and spinal cord

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3
Q

What are the components of the PNS?

A

Somatic:
-cranial and spinal nerves
Autonomic:
-Parasympathetic, Sympathetic, Enteric

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4
Q

What are the main components of the neuron?

A
  • dendrites
  • soma (cell body)
  • axon hillock
  • axon
  • terminal branches
  • synapse
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5
Q

Dendrite function

A

receives signals

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6
Q

Soma function

A
  • interpret info from dendrite
  • determine if there is going to be an AP
  • contains nucleus and organelles
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7
Q

Axon hillock function

A

signal becomes an AP –> elicits response

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8
Q

Axon function

A
  • where the AP travels

- contains Myelin Sheath and Nodes of Ranvier

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9
Q

Terminal branches function

A
  • at the very end right before synapse

- sends out NTs into synapse

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10
Q

Synapse function

A

specialized point of functional contact between neurons, or between a neuron and a target organ

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11
Q

What are the 3 types of neurons that can be found in the nervous system? Structural and Functional

A
Structural:
-multipolar
-bipolar
-unipolar
Functional:
-sensory (afferent)
-motor (efferent)
-interneuron
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12
Q

Multipolar neuron

A

most common, several dendrites and axons

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13
Q

Bipolar neuron

A

rare, single dendrite and single axon arising from a cell body, for special sensory organs (sight and smell)

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14
Q

Unipolar neuron

A

in PNS, axon and dendrite arise from a single process

arising from a soma

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15
Q

Main role of sensory (afferent) neurons and types

A
  • Afferent= arrive
  • signals from receptors to CNS
  • special sensory:
    i. vision
    ii. auditory
    iii. equilibrium
    iv. gustatory (taste)
  • viscerosensory: unconscious
  • somatosensory: conscious
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16
Q

Main role of motor (efferent) neurons and types

A
  • efferent=exit (response)
  • signals from CNS to effectors
  • somatomotor: voluntary; CNS–> skeletal muscle
  • autonomic motor: involuntary; connects vital structures to CNS; smooth muscle, cardiac glands
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17
Q

What is the function of interneurons/associative neurons?

A
  • local integration center
  • comprised of brain and spinal cord
  • connect sensory to motor
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18
Q

Define a reflex

A
  • unidirectional rapid, predictable, and involuntary response to a stimulus
  • NO cortical involvement
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19
Q

Define a reflex arc

A

neural pathway that controls a reflex

-sensory receptor –> sensory neuron –> interneuron –> motor neuron –> effector

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20
Q

Types of reflexes in human body

A
  • somatic: skeletal muscle (ex: knee jerk)

- autonomic: smooth muscle, cardiac, and glands (ex: salivary reflex)

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21
Q

Explain the steps of the myotatic reflex, starting from the hit of the hammer to the leg kicking outwards.

A
  • “knee jerk”
  • hammer hit → extensor muscle → muscle sensory receptor → sensory neuron/ motor neuron in spinal cord/ interneuron synapse inhibits motor neuron in flexor muscles → motor neuron sends AP to extensor muscle to contract/ flexor relaxes due to inhibition of motor neuron
22
Q

Explain the steps of the Flexor Withdrawal Reflex. When does this reflex come into play in function?

A
  • flexor reflex + crossed extension reflex
    i. flexor reflex: painful stimulus → afferent neuron → interneurons → efferent neurons → excitation of flexors, inhibition of extensors
    ii. crossed extension: painful stimulus → afferent neuron → interneurons cross midline → efferent neurons → excitation of extensors, inhibition of flexors
23
Q

Function of astrocytes and PNS equivalent

A

-are glial cells
-support cells
-maintain BBB
-tissue repair
-1/2 of CNS neural tissue
PNS equivalent= satellite cells

24
Q

Function of ependymal cells and where they are found

A
  • they produce and facilitate exchange of CSF

- line ventricle and central canal walls, forming choroid plexus

25
Function of microglia
"macrophages of the CNS" - remove foreign bodies - protect against infection
26
Oligodendrocytes
-CNS myelin creation | one cell can myelinate multiple axons
27
Shwann cells
- PNS myelin creation | - multiple cells required to myelinate one axon
28
Role and anatomy of Myelin
- speed up AP - AP jumps node to node - insulate strength/integrity of AP - mixture of proteins and phospholipids → white matter
29
Nodes of Ranvier
- spaces between myelin sheath - enables regeneration of AP - saltatory transmission--> AP jumping from node to node
30
Where is a synapse found? Main components?
- found between a neuron and target cell/organ - components are the presynaptic terminal (first neuron that starts the info and sends it down), synaptic cleft (chemical signals/NTs), and postsynaptic element (dictates type of synapse)
31
Different synapse types:
Axodendritic Axosomatic Axoaxonix Dendrodendritic
32
Axodendritic
most common, axons of pre communicate with dendrites of post
33
Axosomatic
axons of pre go to cell body/soma of post
34
Axoaxonix
axon to axon, mediators (inhibit or facilitate)
35
Dendrodendritic
dendrite to dendrite, mainly found in vision/smell, uncommon
36
Electrical Synapse
- directly connected via gap junctions - fast communication (1 ms) - bi-directional - latent period very short - most typically seen in hypothalamus - pro: quick - con: not selective
37
Chemical Synapse
- slower process - take up to a minute - increased magnitude - larger distance between neurons - stronger and last longer - these are the majority
38
Resting Membrane Potential
- neg. 70 mV - intracellular K+ - extracellular Na+, Cl- - maintained by the sodium-potassium pump and ion channels
39
Ionotropic receptors
"Ligand-gated channels" | -NT binds, channel opens, ions flow across membrane
40
Metabotropic receptors
"G-protein coupled receptors" -NT binds, G-protein is activated, G-protein subunits or intracellular messengers modulate ion channels, ions flow across membrane, ion channels open
41
Agonists
same effect as the NT
42
Antagonists
block the effect of the NT
43
Inverse Agonists
opposite effect of NT
44
Neuromodulators
affect the likelihood that the NT will bind
45
Excitatory postsynaptic potentials (EPSP)
- causes depolarization of the cell - increase Na permeability into cell - increase likelihood of postsynaptic AP
46
Inhibitory postsynaptic potentials (IPSP)
- cause hyperpolarization of cell - increase Cl permeability - decrease likelihood of postsynaptic AP
47
Temporal summation
several impulses from one neuron at a time
48
Spatial summation
several impulses from several neurons at the same time
49
Continuous vs Saltatory conduction
Continuous is unmyelinated and saltatory is myelinated so it is faster
50
Conduction velocity is dependent on:
1. Fiber diameter 2. Presence of myelin 3. Thickness of myelin 4. PNS: fiber classification