Lecture 1 (Endocrine/Patho of DM Flashcards
What is the Endocrine System?
Integrated network throughout the body (secreting organs/glands, hormones, target organs)
Endocrine System Function
to coordinate, integrate and regulate cellular activity throughout the body to maintain homeostasis
Body processes controlled by endocrine system (7)
- respiration
- metabolism
- reproduction
- sensory perception
- movement
- sexual development
- growth
Endocrine Tissues (9)
- hypothalamus
- pituitary gland
- parathyroid
- pancreas
- thyroid
- adrenal glands
- pineal gland (brain)
- ovaries
Testes
Tissues with endocrine function (4)
- Kidneys
- Brain
- Gut
- Adipocytes
Endocrine Hormone Signaling
Hormone is released into the circulation. Travels via blood to target distant from site of release to produce biologic effect
Paracrine Signaling
Hormone released. Travels short distance to produce a biologic effect on a neighboring cell
Autocrine Signaling
Hormone released.Produces biologic effect on the same cell which it is released (same cell type)
T or F? Hormones can have multiple sites of action of different signaling types?
True
Peptide Hormones
structurally more complex protein structures
Amino Acid Hormones
simple amino acid structures (not full folded proteins)
Steroid Hormones
Lipophilic structures
Membrane receptors
bind to receptor on cell surface. Cause signal transduction
Intracellular Receptors
cross cell membrane. Bind to intracellular targets to cause gene transcription
Which are membrane receptors?
Peptide & Amino Acid Hormones
