lecture 1 embryonic eye development Flashcards
receptive fields are first _____ and later become _____
anisotropic, isotropic
glutamate receptors first appear on what?
off bipolar cells
(T or F) the pupillary membrane usually regresses but may persist after birth
true
adult retinal progenitor cells come from what part of the eye?
ciliary body
(T or F) amacrine cells have stronger on responses
true
retinal cells are derived from retinal cell progenetors, either cone or ganglion or both. name the progenitor for the following
A) bipolar cells
B) horizontal cells
C) amacrine cells
D) rods
A) both
B) cone
C) ganglion
D) both
which of the following develop from the optic cup?
A) retina
B) lens
C) pigmented epithelium
D) iris
A, C, and D (lens is developed from lens placode)
during weeks 3-4, the _____ becomes the optic nerve
optic stalk
eye fields develop from
A) posterior neural ectoderm
B) anterior neural plate
C) posterior neural plate
D) anterior neural ectoderm
B) anterior neural plate
(T or F) the lens vesicle is derived from neural endoderm
false (lens comes from surface ectoderm)
which tissue does the eye not originate from?
A) anterior neural plate
B) prosencephalon
C) mesencephalon
D) eye fields
C) mesencephalon
(T or F) the hyaloid artery surrounds the back of the lens and follows the choroid fissure during eye development
true
give the order in which retina cells populate the retina
1) amacrine cells
2) (cones, ganglion, and horizontal)
3) rods
4) bipolar cells
5) muller cells
what is the first sulci “fold” that happens in the brain? when in development does it happen?
when the eye fields/optic grooves fold in at 22 days gestation
day 17 marks the development of what?
day 25 marks the development of what?
day 29 marks the development of what?
day 17=eye fields, day 25 =optic groove, 29=optic stalk and optic vesicle
the optic groove becomes which 2 things?
the optic stalk and the optic vesicle
the lens placode will become invaginated during which week(s)?
weeks 5-6
lens is on the inside by week ___
6
name the artery responsible for providing nutrients to growing ocular cells during development
hyaloid artery
name the opening in the optic vesicle that allows for the hyaloid artery to grow into
choroid fissure
how is the anterior chamber formed?
posterior lens fibers send a message to the anterior lens fibers to undergo apoptosis
The outer corneal epithelium comes from ____?
surface ectoderm
The inner corneal layer comes from ____?
neural crest tissue
The RPE consists of how many layers?
1 cell layer thick
during weeks 7-8, the RPE ____ and the retina____
thins, thickens
what is the job of the radial glia?
they help cells migrate to the right location
muller cells respond to ____
injury
(T or F) It is good practice to patch an infants eye
NO, don’t ever patch an infants eye. light stimulation is crucial to having well formed neural pathways.
(T or F) Muller glia act as retinal progenitors in adults
true
(T or F) 3 days of monocular deprivation during the critical period of vision development is sufficient to cause a significant change in vision
true
What effect does dark rearing mice for their first 3 weeks of life have on their visual development?
A) Ocular dominance columns do not develop at all
B). The fraction of bi-stratified On-Off ganglion cells increases
C) The fraction of Off bipolar cells increases
D) Significant photoreceptor degeneration occurs
B). The fraction of bi-stratified On-Off ganglion cells increases
