Lecture 1 - CNS Development and Intro Flashcards

1
Q

Central Nervous System

A

Brain and spinal cord

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2
Q

Brain

A

Sorts through and properly routes incoming sensory information; initiates, controls, and coordinates most muscular activity except simple reflexes; site of origin of 12 cranial nerve pairs (4 pairs carry parasympathetic fibers III, VII, IX, and X)

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3
Q

Functions of the Brain

A

Sensory, motor, and cognitive

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4
Q

Spinal Cord

A

First CNS structure encountered by most incoming sensory information except sensory fibers in cranial nerves; last relay station for most motor information except ANS motor fibers; site of coordination of most reflex arcs

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5
Q

PNS

A

Made up of transmission pathways carrying information between the CNS and external/internal environments; includes 12 pairs of cranial nerves, 31 pairs of spinal nerves, sensory receptors in the skin and wall of the gut tube as well as in tendons and skeletal muscles

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6
Q

ANS

A

Entirely motor; innervates smooth muscle and glands (viscera); subdivided into sympathetic (fight or flight; thoracolumbar) and parasympathetic systems (feed and breed; craniosacral)

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7
Q

Nucleus

A

Aggregation of dendrites and nerve cell bodies in the CNS

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8
Q

Ganglion

A

Aggregation of dendrites and nerve cell bodies in the PNS

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9
Q

Nerve

A

Bundle of fibers (axons) in the PNS

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10
Q

Tract

A

Bundle of fibers (axons) in the CNS

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11
Q

Commissure

A

Tract in the CNS that crosses from one side to the other

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12
Q

White Matter

A

Areas of myelinated axons

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13
Q

Gray Matter

A

Areas of unmyelinated axons, cell bodies, and dendrites

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14
Q

When does the formation of the nervous system occur during the embryonic stage?

A

End of 2nd week to end of 8th week

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15
Q

Stages in Neural Tube Development

A

Neural plate to neural folds to neural tube

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16
Q

Parts of Tripartite Brain

A

Prosencephalon (further divided in pentapartite brain), mesencephalon, and rhombencephalon (further divided in pentapartite brain)

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17
Q

Parts of Pentapartite Brain

A

Telencephalon (most anterior), diencephalon, mesencephalon, metencephalon, and myelencephalon

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18
Q

Anencephaly

A

Failure of the cranial end of the neural tube to close

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19
Q

Holoprosencephaly

A

Failure of prosencephalon to divide into 2 cerebral hemispheres; often associated with facial deformities such as a single orbit with 2 eyes, 1 eye, or no eyes, a proboscis-type nose located above the eye, or a cleft lip and palate

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20
Q

Spina Bifida Occulta

A

Results from a failure of the inferior neuropore to close; vertebral arch/es fail to develop in caudal area; spinal cord function is usually normal

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21
Q

Spina Bifida Cystica

A

Characterized by a sac-like cyst at the caudal end of spine; spinal cord and/or meninges may be found in the cyst; spinal cord function may be impaired; may be lower extremity dysfunction; bladder and bowel function may be impaired

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22
Q

Meningocele (form of spina bifida cystica)

A

Only meninges found in sac; spinal cord function may be impaired; signs and symptoms vary depending on location and severity of malformation

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23
Q

Meningomyelocele (form of spina bifida cystica)

A

Both meninges and spinal cord are found in sac; always results in abnormal growth of spinal cord; lower extremity paralysis; bowel and bladder dysfunction; loss of sensation to lower limbs

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24
Q

Myeloschisis (form of spina bifida cystica)

A

Failure of caudal neural folds to close; most severe of the defects

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25
Q

Arnold-Chiari Deformity

A

Inferior cerebellum and medulla are elongated and protrude into vertebral canal; medulla and pons are small and deformed; hydrocephalus; malformation of lower cranial nerves leads to deafness, tongue, facial muscle, lateral eye movement weakness

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26
Q

What is found in the lumina, floor, and roof of the telencephalon?

A

Lumina: Lateral ventricles 1 and 2
Floor: Basal nuclei (ganglia), olfactory lobes and nerves (subconscious motor control and muscle tone)
Roof: Cerebral cortex

27
Q

What is found in the lumina, roof, walls, and floor of the diencephalon?

A

Lumen: Third ventricle
Roof: Epithalamus
Walls: Thalamus
Floor: Hypothalamus and infundibulum

28
Q

Epithalamus

A

Habenular nuclei involved in emotional and visceral responses to odors; pineal body

29
Q

Thalamus

A

Major relay center for afferent and efferent information to and from cerebrum and other areas of the brain

30
Q

Hypothalamus

A

Mamillary bodies involved in olfactory reflexes and emotional responses to odors; supraoptic and paraventricular nuclei

31
Q

Functions of Diencephalon

A

Controls and integrates ANS; associated with many kinds of visceral activity; intermediary between nervous and endocrine systems; controls normal body temperature; maintains extracellular fluid volume; biorhythm oscillator

32
Q

What is found in the lumen, roof (tectum), and floor of mesencephalon?

A

Lumen: Cerebral aqueduct (of Sylvius)
Roof (Tectum): Superior colliculi (visual reflexes) and inferior colliculi (auditory and olfactory reflexes)
Floor: Tegmentum (red nucleus, substantia nigra, various tracts) and cranial nerve nuclei 3 and 4

33
Q

What is found in the lumen, roof, and floor of metencephalon?

A

Lumen: Part of 4th ventricle
Roof: Cerebellum
Floor: Pons (cranial nerve nuclei 5-8; pontine nuclei, which is the relay between cerebrum and cerebellum; sleep center; respiratory center)

34
Q

Cerebellum

A

Has a cortex and is connected to other parts of the brain via large pairs of fibers tracts called peduncles

35
Q

Functions of Cerebellum

A

Coordinates skeletal muscle movements, maintain equilibrium and posture, and synergic control of muscle activity

36
Q

What does the inferior peduncle connect to?

A

Connects to medulla and spinal cord

37
Q

What does the middle peduncle connect to?

A

Pons

38
Q

What does the superior peduncle connect to?

A

Midbrain

39
Q

What is found in the lumen, main part, and roof of the myelencephalon?

A

Lumen: Rest of 4th ventricle
Main Part: Medulla obloganta
Roof: Posterior choroid plexus

40
Q

Medulla Nuclei

A

Vestibular nuclear complex, sensory nuclei, and portions of reticular formation

41
Q

Medulla Pyramids

A

Consist of lateral corticospinal tracts

42
Q

Medulla Olives

A

Site of nuclei related to cerebellum

43
Q

Medulla Reflex Centers

A

Cardiac center, vasomotor center, and centers related to respiration; various nonvital centers

44
Q

White Ramus Communicans

A

Located in the thoracolumbar region prior to branching into dorsal/ventral primary ramus; carries myelinated PRE-ganglionic fibers

45
Q

Gray Ramus Communicans

A

Located in the thoracolumbar region prior to branching into dorsal/ventral primary ramus; carries UN-myelinated POST-ganglionic fibers back to spinal nerve

46
Q

What 2 major branches do spinal nerves divide into?

A

Dosal/Ventral primary rami

47
Q

Paravertebral Ganglia

A

Linked together into a long chain on either side of the vertebral column in the thoracolumbar region; site of cell bodies of postganglionic sympathetic nerves; site of synapses between preganglionic myelinated sympathetic neurons and postganglionic non-myelinated sympathetic neurons

48
Q

Splanchnic Nerve

A

Nerve supplying viscera

49
Q

Prevertebral Ganglia

A

Typically found anterior to abdominal aorta; site of synapses between preganglionic myelinated sympathetic neurons and postganglionic non-myelinated neurons

50
Q

Reflex Arc

A

Pathway that leaves from and returns to the CNS; consists minimally of a sensory pathway and a motor pathway

51
Q

Afferent (Sensory) Pathways

A

Somatic afferent pathways carry sensation from non-visceral structures such as the skin and skeletal muscle; visceral (splanchnic) afferent pathways carry sensations from viscera

52
Q

Efferent (Motor) Pathways

A

Somatic efferent pathways carry motor signals to skeletal muscles; visceral (splanchnic) motor pathways carry motor signals to smooth or cardiac muscles

53
Q

Association Neurons (Interneurons)

A

Some reflex arcs consist only of an efferent neuron and an afferent neuron; most have intervening neurons (interneurons) in the CNS that modulate the interaction between the afferent and the efferent neurons

54
Q

Monosynaptic Pathways

A

Pathways consisting only of afferent neurons and efferent neurons; each pathway has a single synapse

55
Q

Polysynaptic Pathways

A

Pathways that include interneurons as well as afferent and efferent neurons; each pathway has multiple synapses

56
Q

Resting Potential of Neuron Cell Body

A

-65mV

57
Q

Excited Potential of Neuron Cell Body

A

-45mV; typically due to influx of Na+

58
Q

Inhibited Potential of Neuron Cell Body

A

-70mV; typically due to influx of chloride ion or efflux of K+

59
Q

Somatosensory Axis

A

Sequence of structures involved in the transmission of a sensory signal from the peripheral receptors to higher brain centers; components include:

Peripheral receptors, afferent neurons (primary, secondary, tertiary), spinal cord/brainstem, reticular substance (medulla, pons, mesencephalon), cerebellum, thalamus, and somesthetic areas of cerebral cortex

60
Q

Primary Afferent Neurons

A

Synapse in the posterior horns of spinal cord or sensory nuclei in the brain

61
Q

Secondary Afferent Neurons

A

Synapse in the thalamus

62
Q

Tertiary Afferent Neurons

A

Synapse in the somesthetic areas of cerebral cortex

63
Q

Skeletal Motor Nerve Axis

A

Sequence of structures involved in the transmission of an action potential from the higher brain centers to skeletal muscles; includes:

Motor cortex of cerebrum, efferent pathways (upper motor neurons extending from cortical areas to the anterior horns of the spinal cord and alpha/lower motor neurons extending to the skeletal muscles), and effectors (skeletal muscles)

64
Q

Processing Areas of Skeletal Motor Nerve Axis include what structures?

A

Basal nuclei (putamen, globus pallidus, subthalamic nuclei) in the telencephalon, thalamus in the diencephalon, and spinal cord reflexes