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Physiology SI > LECTURE 1: Body Fluid compartment and determination. ECF and ICF > Flashcards

LECTURE 1: Body Fluid compartment and determination. ECF and ICF Flashcards

1
Q

LOCALISATION OF INTERNAL ENVIRONMENT

(ECF OR INTERSTITIUM)

A
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2
Q

IONIC COMPOSITION OF ECF

A
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3
Q

MILIEU EXTERIEUR/ INTERIOR

A

CLAUDE BERNARD

MILIEU EXTERIEUR: PHYSICALLY SURRROUNDS WHOLE ORGANISM

MILIEU INTERIEUR: IN WHICH TISSUES AND CELLS LIVE

'’THE CONSTANCY OF THE INTERNAL ENVIRONMENT IS THE CONDITION FOR A FREE AND INDEPENDENT LIFE’’

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4
Q

DEFINITION OF PHYSIOLOGY

A
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5
Q

GIVE AN EXAMPLE OF ECF K+ REGULATION

A
  1. PARAMETER: 3.5-5mM; set point is genetically encoded
  2. monitor deviations from set point glomerosa cells of adrenal gland
  3. elevate ECF K+ ion concentration: aldosterone production
  4. aldosterone acts on particular kidney cells, K+ ion excretion from body will increase
  5. DECREASES ECF K+ ion concentration

***NEGATIVE FEEDBACK CONROL***

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6
Q

PHYSIOLOGICAL PARAMETERS TO BE REULATED?

A
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7
Q

PHYSIOLOGICAL CONTROL MECHANISMS?

A

THERE ARE 4…..

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8
Q

DRAW EUKARYOTIC CELL:

A
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9
Q

NUCLEUS

A

GENOME OF THE CELL

22 PAIRS OF AUTOSOMES AND 1 PAIR OF SEX CHROMOSOMES

ENZYME ACTION TO REPAIR AND TRANSCRIBE DNA

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10
Q

MITOCHONDRIA

A

2 MEMBRANES ( INNER AND OUTER (WITH PORES)

OWN DNA (GAMMA DNA)

GENERATE ATP VIA OP

CAC

SITE OF SEQUESTRATION OF CA2+ IONS

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11
Q

rER

A
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12
Q

MEMBRANE NETWORK

RIBOSOMES, TRANSLATION OF MRNA

PTM

A
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13
Q

GOLGI APPARATUS

A

PTM

SORTS PROTEINS AND PACKAGES THEM FOR DELIVERY

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14
Q

sER

A
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15
Q

NO RIBOSOMES

CONVERSION OF HYDROPHOBIC SUBSTANCES TO WATER SOLUBLE

SYNTHESIS OF LIPIDS

CA2+ POOL OF IONS

A
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16
Q

PROTEASOMES

A

NOT MEMBRANE BOUND

DEGRADITIVE FUNCTION

17
Q

FREE RIBOSOMES

A

TRANSLATE MRNA FOR CYTOSOLIC PROTEINS

18
Q

PERIOXISOMES

A

OXIDATIVE ENZYMES

METABOLIZES EHTANOL TO ACETALDEHYDE

19
Q

CYTOSKELETON

A

ACTIN AND INTERMEDIATE FILAMENTS

MICROTUBULES

CONTRACTION MOVEMENT

INTRACELLULAR TRANSPORT

20
Q

PLASMA MEMBRANE

A

SEPARATES CELL INTERIOR FROM ENVIRONEMENT

CONNECTS INDIVIDUAL CELLS TO OTHERS

21
Q

PHOSPHOLIPID MOLECULE AND PHOSPHOLIPID BILAYER

A
22
Q

OUTER LOCALISED LIPIDS AND THEIR FUNCTION

A

PHOSPHOLIPIDS:

PHOSPHATIDYLCHOLINE (LIPID RAFT)

SPHINGOMYELIN (LIPID RAFT)

CHOLESTEROL= INNER/OUTER (MEMBRANE FLUIDITY AND LIPD RAFT)

GLYCOLIPIDS:

GPI (GLYCOSYLPHOSPHATIDYLINOSITOL)= PROTEIN ANCHOR

23
Q

INNER LOCALISED LIPIDS AND THEIR FUNCTION?

A

PHOSPHOLIPIDS:

P. SERINE

P. ETHANOLAMINE

P. INOSITOL

CHOLESTEROL= INNER/OUTER=MEMRANE FLUIDITY AND LIPID RAFT

24
Q

LIPID: LOCALISATION AND FUNCTION?

A
25
Q

MEMBRANE STRUCTURE?

A
26
Q

CFTR

A

CYSTIC FIBROSIS= AUTOSOMALRECESSIVE DISORDER

-CHRONIC LUNG INFECTIONS, PANCREATIC INSUFICIENCY, INFERTILITY IN MALES

MUTATION OF GENE ON CHROMOSOME 7 (CODING FOR ABC TRANSPORTER)

MOST COMMONLY DELETION OF A PHE AT POSITION 508

CFTR= CL-CHANNEL, REGULATES other membrane transporters (ENAC)

ENAC=defective in patients with CF

27
Q

urea

A

Hypotonic—>lysis and swelling

ineffective osmole= cannot pass through PM

28
Q

Functions of PM proteins:

A

selective transport of molecules

cell recognition via surface antigens

cell communication (PM receptors)

tissue organisation through adhesion molecules

enzymatic activity

determination of cell shape (linking cytoskeleton)

29
Q

volumes of body fluid compartments

A
30
Q

Ionic composition of ECF and ICF?

A
31
Q

transcellular Fluid

A

CSF

ocular fluid

synovial fluid

pleural cavity

peritoneal cavity

32
Q

measurements of volume in fluid compartments?

A
33
Q

fluid compartments of prototypic adult human weighing 70kg

A
34
Q

parameters and regulation

A

increase aldosterone

decrease: negative FB control

35
Q

physiological control mechanisms

A

Physiology SI (5 decks)

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