Lecture 1 Flashcards

1
Q

What does the hypothalamus do

A

Maintains homeostasis

Body temperature, blood pressure, fluid and electrolyte balance, body weight

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2
Q

What does the nucleus of the solitary tract do

A

Collects sensory information from the vagus nerve and relay it to hypothalamus

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3
Q

What sort of sensory information does the nucleus of the solitary tract include

A

Blood pressure

Gut distension

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4
Q

What does reticular formation do

A

Nucleus in the bloodstream that recieves a variety of input from the spinal cord

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5
Q

What sort of information is linked with reticular formation

A

Skin temperature

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6
Q

Where is the hypothalamus

A

Below the thalamus and posterior to the optic chiasm

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7
Q

What is the retina

A

Fibres from the optic nerve go to a small nucleus in the hypothalamus

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8
Q

What is the nucleus called that the retina fibres go to

A

Suprachiasmatic nucleus

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9
Q

What does the suprachiasmatic nucleus do

A

Regulates circadian rhythms

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10
Q

Hat are the circumventricular organs

A

These nuclei are located along the ventricles

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11
Q

What is unique about the circumventricular nuclei

A

They lack the blood brain barrier

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12
Q

What does the limbic and olfactory system do

A

Help to regulate behaviours such as eating and reproduction

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13
Q

What do intrinsic receptors do

A

Monitor temperature and ionic balance

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14
Q

What are the 2 main outputs

A

Neural signals

Endocrone signals

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15
Q

Where do neural signals go

A

To the autonomic system

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16
Q

Where do the hypothalamus project too

A

Medulla

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17
Q

What can the hypothalamus control

A

Heart rate
Vasoconstriction
Digestion
Sweating

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18
Q

Where do endocrone signals travel too

A

Pituitary gland

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19
Q

Where in the hypothalamus send their axons to the pituitary gland

A

Third ventricle

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20
Q

Hypothalamus cells in the third ventricle send their axons to which pituitary gland

A

Posterior

21
Q

What do the axon terminals release into the bloodstream

A

Oxytocin

Vasopressin

22
Q

Where do smaller cells send their axons

A

To the base of the pituitary

23
Q

Where do the smaller cells axons release hormones into

A

Capillary system of the anterior pituitary

24
Q

What can the hypothalamus change

A

Blood pressure
Body temperature
Metabolism
Adrenaline levels

25
Q

What are the 2 pituitary glands called

A

Posterior pituitary

Anterior pituitary

26
Q

What is adenohypophysis

A

Anterior pituitary

27
Q

What is neurohypophysis

A

Posterior pituitary

28
Q

What 3 cells types are in the adenohypophysis

A

Acidophils
Basiphils
Chromophobes

29
Q

Is it true or false that the neurohypophysis is an extension of the hypothalamus

A

True

30
Q

How are hormones released from the anterior pituitary gland

A

The hypothalamus secretes releasing hormones which stimulate hormones release in the pituitary

31
Q

What are releasing factors

A

Releasing hormones that stimulate hormone release

32
Q

What is it meant about true hormones

A

Secreted in the bloodstream and act at a distance

33
Q

What is vasopressin thought to stimulate

A

ACTH secretion

34
Q

What is CRH

A

Corticotropin releasing hormones

35
Q

How many amino acids does CRH have

A

41 amino acids straight chain

36
Q

What group is crucial for activity

A

Amide group

37
Q

What is TRH

A

Thyrotropin releasing hormones

38
Q

Hypothalamus secretes TRH causes what

A

Release of TSH from anterior pituitary

39
Q

What is the only problem in secreting TRH

A

It can also cause the release of prolactin, growth hormone and MSH

40
Q

Where is TRH produced

A

Medial neurons of the hypothalamus

41
Q

What is GH

A

Growth hormone

42
Q

How many amino acids is growth hormone

A

191

43
Q

Name another hormone that is in GH family

A

Prolactin

44
Q

How many amino acids does prolactin have

A

198

45
Q

What is required for signal transduction of GH

A

Receptor dimerization

46
Q

How many binding sites do GH have

A

2 GH receptor monomers to form a dimer in the plasma membrane

47
Q

What will a dimerised GH receptor recruit

A

Cytoplasmic tyrosine kinase

48
Q

By recruiting a cytoplasmic tyrosine kinase what does it do

A

Phosphorylates the GH receptor

49
Q

What happens after phosphorylation

A

Signal transducers and activators of transcription are phosphorylated and moved to the nucleus