Lecture 1 Flashcards
Describe (generally) the Adaptive (specific) Immune System
Develop it (9mos - 1 yr; fully developed by 7 years)
can live without it
specific
Describe the Innate Immune System
Born with it
Have it for life
Non-specific
How are specific immune system cells developed/differentiated?
Hematopoeisis: lymphocytes come from a common progenitor stem cell (pluripotent)
the correct micro-environment will teach it to become a specific cell
Which cd cell identifies the stem cell that differentiates into a T or B cell?
cd34
The first cell is in the bone marrow and the cytokines present will decide if it will be a B or T cell
Which antibodies to B220/CD45+ make?
IgM, IgG, IgD, IgE, IgA
Which branches of T cells are made while still in the bone marrow?
gamma delta prehistoric T cell and alpha beta “regular” T cells
describe gamma delta prehistoric T cells
gamme delta are the two chains of the TCR
develop in the bone marrow and then go to the peripheral site
found at various sites like gut and lungs, places with mucus
alpha beta “regular” T cells
leave the bone marrow and go to the thymus
form double positive alpha beta; CD4 and CD8
while in thymus: become single +alphabeta, CD4 or CD8
Move to lymph node and spleen
What type of cells do CD8 become?
killer T cells
aka cytotoxic T cell or cytolytic T celll
What type of cells do CD4 cells become?
Helper T cells –> cytokine secreting cells
Treg T cells are a CD4 cell that can suppress an immune response
How do B cells recognize antigens?
whole extracellular antigens
highly specific
the B cell receptor is an antibody on the surface of the cell (it can also be secreted)
How do T cells recognize antigens?
the recognize processed antigens (presented by macrophages)
highly specific
T cell receptor (TCR) is on the surface of the T cell and are NEVER secreted
Which organs are involved as physical barriers?
Spleen Lymph Nodes Blood/Lymph Gut Skin
