Lecture # 07_Fall Flashcards
The action of local anesthetics includes loss of ____, ____, and ___ function
sensory, motor, and autonomic
How do LAs work?
They enter the cell and bind to voltage-gated Na channels, prevent the influx of Na, which slows conduction
___ nerve fibers are the smallest and slowest
C
Which nerve fibers are responsible for
A-delta, and C
Match the structure with the protective sheath that surrounds it:
fascicle, axon, fiber
endoneurium, epineurium, perineurium
Fiber = endo
fascicle = peri
axons= Epi
Nerve fibers are surrounded by ____ and bundled into _____ which are surrounded by _______. ____ are groups of fascicles are surrounded by ______.
endoneurium, fascicles, perineurium, Axons, epineurium
LAs bind at the ____ in between myelinated segments
nodes
What is the sequence of the differential blockade?
Autonomic -> Sensory -> Motor
B->C->A->
Which fibers are myelinated?
only B fibers (autonomic fibers)
Do LAs have faster onset with myelinated or non-myelinated fibers?
myelinated
Do LAs have faster onset with small fibers or large fibers?
small
_ fibers are mostly motor, _ fibers are mostly autonomic, and ___ fibers are mostly sensory
A, B, C
T or F. Recovery from LAs is usually in the opposite order of onset.
True.
Usually you lose B (Autonomic) -> C (Sensory) -> A (Motor)
And they return in the opposite order:
A (Motor) ->C (Sensory) -> B (Autonomic)
List the order you lose your senses in.
Temp (cold -> hot) -> pain -> touch -> deep pressure -> proprioception
Local anesthetics are weak ____ that become charged by accepting a proton on the _____.
Bases, amine
