Lect8: Lipid Metabolism Flashcards
What is the significance of acetyl-CoA in cholesterol metabolism?
Acetyl-CoA is a precursor for cholesterol synthesis but cannot be broken down into acetyl-CoA.
What percentage of bile acids are typically reabsorbed in enterohepatic circulation?
About 95% of bile acids are reabsorbed.
Why is cholesterol important in the body?
Cholesterol is essential for forming steroid hormones and is a component of cell membranes.
What is enterohepatic circulation?
It is the circulation of bile acids and bile salts between the liver and intestines.
What is the role of statins in cholesterol management?
Statins lower cholesterol by inhibiting HMG-CoA reductase, the enzyme responsible for cholesterol biosynthesis.
What molecule is generated during beta-oxidation and enters the TCA cycle?
Acetyl-CoA
What are ketone bodies, and when are they produced?
Ketone bodies are produced from excess acetyl-CoA and are used as an energy source by tissues.
What is the mechanism of action for statins?
Statins act as competitive inhibitors of HMG-CoA reductase.
What is the process called when the body breaks down fatty acids to produce energy?
Beta-oxidation
How do bile acid sequestrants help manage cholesterol levels?
They bind bile acids in the intestine, preventing their reabsorption and promoting their excretion.
