Lect2: Class activity

Question 1

AUC represents

Answer 1

the total drug exposure over time

Question 2

Concentration unit “mg/L”, and time unit “h”. Use these two units to build a unit for AUC.

Answer 2

• mg·h · L-1
• mg·h/L

Question 3

Both clearance and volume of distribution are ________ pharmacokinetic parameters; while elimination rate constant and T1/2 are ________ pharmacokinetic parameters.

Answer 3

Independent; Dependent

Question 4

The equation for the relationship among clearance (CL), the volume of distribution (Vd), and the elimination rate constant (k), is:

Answer 4

𝐶𝐿 = 𝑘 × 𝑉d

Question 5

Write the equation for T1/2 (1) using elimination rate constant (k), and (2) using clearance (CL) and volume of distribution (Vd)

Answer 5

• 𝑡1/2 =0.693/𝑘
• 𝑡1/2 =0.693𝑉𝑑/𝐶𝐿

Question 6

If K increase, what happens to T/12?

Answer 6

decreases

Question 7

If CL increase, what happens to Vd, K, and T1/2?

Answer 7

Vd is unchanged
K increases
T1/2 decreases

Question 8

If Vd increase, what happens to CL, K, and T1/2?

Answer 8

CL remains unchanged
k decreases
T1/2 increases