Lect 28 Flashcards
List the important species that cause malaria
- plasmodium vivax
- p. falciparum
- p. malariae
- p. ovale
- p. knowlesi
malaria lifecycle is complex and has a phase and a phase
- human phase
- mosquito phase
malaria process in humans in initiated by the injection of plasmodium through transmission of mosquito saliva during a bloodmeal
sporozoites (motile forms)
sporozoites migrate to the and asexual division known as the cycle begins
- liver
- schizogony
life cycle form released from the schizogony cycle in the liver are called
Merozoites
Merozoites can infect other liver cells or and start the cycle
- RBC
- Erythrocytic cycle
Once in an RBC, Merozoite enlarges and undergoes a differentiation into a cell termed a
-
Ring trophozoite
- one nucleus
as Ring trophozoite age, they can develop into
- amoeboid trophozoites
single nucleus of a Ring trophozoite can divide to produce a multinucleated form called a
schizont
erythrocytic schizonts are multinucleated cells that produce
erythrocytic merozoites
When happens to erythrocytic merozoites, when the RBC it is in ruptures
- merozoites escape to invade new cells
- schizogony can begin again
- or gametogony is initiated
sexual cycle of malaria is known as ? Can complete sexual cycle occur in humans?
gametogony
- merozoites in erythrocytes can develop into gametocytes
- do not cause cell rupture
- mosqito feeds and takes in gametes -> sexual reproduction requires mosquito
malaria organisms consume
hemoglobin
fever and chills correspond to release of following rupture of RBC which travels to hypothalamus and causes an increased thermal set point
pyrogen
list the natural based immunity to malaria
- sickle cells anemia produces resistance to falciparum malaria
- lack of or resistance to duffy antigen - a receptor for P. vivax
reservoirs for malaria
- humans
- simians