Lect 23 Flashcards
Growth hormones has indirect effects on growth through what hormone
- Insulin-like growth factor
function of Insulin-like growth factor
- stimulates linear growth of bones
- hypertrophy and hyperplasia of tissues
are levels of GH higher in children, adults, or elderly
- highest in children
- decline with aging
what does decline of GH lead to in the body
- loss of lean body mass, fitness, protein synthesis, metabolic rate
When are levels of IGF-1 highest in a person’s lifespan
pubertal peak rate of growth
a GH secreting pituitary adenoma can lead to GH excess which can cause what condition?
- acromegaly
- occurs after puberty when linear growth is complete
- increase in bone size, organ size, hand and foot size, enlargement of tongue
- occurs after puberty when linear growth is complete
acromegaly occurs with GH hypersecretion when epiphyses are ? This results in
- closed in adults
- results in
- bone and soft tissue deformities
- increased protein, decreased fat content
- propensity to be diabetic
what condition can occur if GH excess occurs before puberty
- gigantism
- increased linear grwoth because of stimulation of epiphyseal plates
what is hypopituitarism
deficiency of one/more anterior pitiuitary hormones
what is panhypopituitarism
deficiency of ALL anterior pituitary hormones
List some effects of panhypoituitarism
- adrenal cortex atrophies: secretion of sex hormones decreases
- gonads atrophy: amenorrhea, impotence in men
- thyroid atrophies: cold intolerance, dry skin, mental dullness
- sensitive to stress: (illness, surgery, trauma)
GH deficiency in children can lead to
- failure to grow, short stature
- mild obestiy
- delayed puberty
GH deficiency before puberty results in what condition
Dwarfism
- defects:
- GH secretion, reduced IGF
African pigmy have what defect
- normal GH levels but do not exhibit the normal rise in IGFs with puberty
what is Laron dwarfism
- GH resistant
- genetic defect in expression of GH receptor
- do not produce IGFs in response to GH
