[LEC] UNIT 6 Myelodysplastic Syndrome Flashcards
T or F: MDA is a group of morphological abnormalities seen among elderly px
T
T or F: MDS is heterogeneous, and it affects all cell lines
T
Abnormalities of MDS include
Refractory aenmia
smoldering leukemia
oligoblastic leukemia
preleukemia
Term coined by FAB in 1982
Myelodysplastic Syndrome
Newer classification of WHO is based on
Molecular
Cytogenetic
Immunological
morphological
Patients with MDs have an increased risk of
developing
AML
median age of MDS diagnosis
76
MDS is usually a consequence of
chemotherapy or radiation
MDS are described as what type of disorders
clonal hematologic disorders
T or F: MDS originate from the myeloid cell line
F
phenotypically normal HSC
CHIP
clonal hematopoiesis of indeterminate potential
Risk of transformation to MDS due to a complex of interaction
clonal hematopoiesis of indeterminate potential
Predisposition to MDS
Inherited BM failure syndromes
FA
DBA
SDA
Morphological findings: _______ BM w/ progressive _______
Normocellular; cytopenia
There can be ________ programmed cell death during the
early stage of the disease therefore, peripheral
cytopenias are evident
Increased
Transformation to leukemia is apparent when apoptosis is _______
decreased
Defective development of RBCs
Dimorphic RBC population
Dyserythropoiesis
observed in vit b12 and
folic acid deficiency anemia thus, their levels
must be determined
Oval microcytes
levels and adequacy of stored iron
Hypochromic microcytes
Observed in PB
poikilocytosis
basophilic stippling
howell jolly bodies
siderocytes
Morphologic abnormalities in BM
dyserythropoiesis
dysmyelopoiesis
dysmegakaryotoiesis
Morphologic abnormalities in PB
dysmyelopoiesis
dysmegakaryopoiesis
T or F: Micromegakaryocyte may be present in PBS
T
Abnormal cellular fxn: WBC
Decreased adhesion, deficient phagocytosis
Decreased chemotaxis, impaired microbicidal capacity
