[LEC] interleukins and cytokines from bff Flashcards
IL-1
Pro-inflammatory; induces fever and activates endothelial cells.
IL-2
Stimulates T cell proliferation and survival.
IL-3
Supports hematopoiesis; growth of myeloid progenitors.
IL-4
Promotes Th2 differentiation; induces B cell class switching to IgE.
IL-5
Stimulates eosinophil growth and activation; promotes IgA production.
IL-6
Induces acute-phase proteins and fever; B cell differentiation.
IL-7
T and B cell development in the bone marrow.
IL-8 (CXCL8)
Acts as a chemokine to recruit neutrophils.
IL-9
Mast cell activation; supports Th2 responses.
IL-10
Anti-inflammatory; inhibits Th1 responses and cytokine production.
IL-11
Megakaryocyte and platelet development.
IL-12
Promotes Th1 differentiation; activates NK cells.
IL-13
Similar to IL-4; promotes IgE production and mucus secretion.
IL-15
NK cell development and memory CD8⁺ T cell maintenance.
IL-17
Induces inflammation and recruits neutrophils (produced by Th17).
IL-18
Stimulates IFN-γ production by NK and T cells.
IL-21
Helps B cells; supports Tfh cell function.
IL-22
Maintains epithelial barrier and promotes antimicrobial peptides.
IL-23
Maintains and expands Th17 cells.
IL-27
Regulates T cell responses; both stimulatory and inhibitory effects.
IL-33
Activates ILC2s; promotes Th2 responses.
TNF-α
Key pro-inflammatory cytokine; induces fever and recruits immune cells.
TNF-β (lymphotoxin)
Lymphoid organ development and cytotoxic functions.
IFN-α and IFN-β
Antiviral responses; increase MHC I expression and activate NK cells.
IFN-γ
Activates macrophages; enhances antigen presentation; Th1 cytokine.
TGF-β
Immunoregulation; induces Tregs and suppresses immune activation.
GM-CSF
Differentiation of granulocytes and macrophages.
M-CSF
Stimulates monocyte and macrophage development.
