[LEC] historical background

Question 1

Father of Scientific History

Answer 1

Thucydides

Question 2

Recognized the “immune” status of individuals who had previously recovered from plague (430 BC)

Answer 2

Thucydides

Question 3

Immunization by inhaling is known as

Answer 3

Insuffation

Question 4

Method of immunization against smallpox

Answer 4

Variolation

Question 5

Allowed her son to be inoculated (variolation)

Answer 5

Lady Mary Wortley Montagu

Question 6

Smallpox vaccination (1798)

Answer 6

(Edward) Jenner

Question 7

Father of Immunology

Answer 7

Louis Pasteur

Question 8

Phagocytosis (1862)

Answer 8

Ernest Haeckel

Question 9

Invented live attenuated, chicken cholera, and anthrax vaccine (1862)

Answer 9

Louis Pasteur

Question 10

First report of live attenuated vaccine for rabies (1885)

Answer 10

Therapeutic vaccination

Question 11

Cellular theory of immunity through phagocytosis (1883-1905)

Answer 11

Elie Metchnikoff

Question 12

Father of Phagocytosis Theory

Answer 12

Elie Metchnikoff

Question 13

Proposed humoral theory of immunity (1890)

Answer 13

Emil Von Behring and Shibasaburo Kitasato

Question 14

Demonstrated cutaneous (delayed-type) hypersensitivity (1891)

Answer 14

Koch

Question 15

Antibody formation theory (1900)

Answer 15

Paul Ehrlich

Question 16

Immediate hypersensitivity anaphylaxis (1902)

Answer 16

Paul Portier and Charles Richet

Question 17

Arthus reaction of intermediate hypersensitivity (1903)

Answer 17

Nicolas Maurice Arthus

Question 18

Hypothesis of antigen-antibody binding (1938)

Answer 18

Marrack

Question 19

Hypothesis of allograft rejection
Acquired Immunologic Tolerance with Burnet (1944)

Answer 19

Peter Medawar

Question 20

Development of Polio vaccine (1949)

Answer 20

Salk and Sabin

Question 21

Vaccine against yellow fever (1951)

Answer 21

Reed

Question 22

Graft-versus-Host reaction (1953)

Answer 22

Dick W. van Bekkum

Question 23

Clonal Selection Theory (1957)

Answer 23

Burnet

Question 24

Interferon (viral interference) (1957)

Answer 24

Alick Isaacs and Jean Lindenmann

Question 25

Human Leukocyte Antigen (HLAs) (1958-1962)

Answer 25

Jean Dausset

Question 26

T cell and B cell cooperation in immune cooperation (1964-1968)

Answer 26

Henry Claman

Question 27

Identification of antibody molecule (1972)

Answer 27

Gerald M. Edelman and Rodney R. Porter

Question 28

First monoclonal antibodies (1975)

Answer 28

R. Cesar Milstein and George Kohler

Question 29

Identification of genes for T cell receptor (1985-1987)

Answer 29

James P. Allison

Question 30

Monoclonal hepatitis B vaccine (1986)

Answer 30

Pablo DT Valenzuela

Question 31

Th1 versus Th2 model of T helper cell function (1986)

Answer 31

Mossman

Question 32

Identification Toll-like receptor (1996-1998)

Answer 32

Jules Hoffman and Bruce Beutler

Question 33

FOXP3, the gene directing regulatory T cell development (2001)

Answer 33

Ramsdell and colleagues

Question 34

Development of human papilloma virus vaccine (2005)

Answer 34

Ian Frazer