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[3Y2S] - MT6326 SERO > (lec) immune system > Flashcards

(lec) immune system Flashcards

1
Q

Composed of cells, tissues and organs that provides the body mechanisms to resist infection and
disease

A

lymphoid system

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2
Q

clear substance from the interstitial fluid which flows through the lymphatic vessels

A

lymphatic fluid

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3
Q

primary or secondary: lymphoid organ associated with the acquisition of immunocompetency

A

primary

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4
Q

primary or secondary: lymphoid organs which serves as the training ground of immune cells

A

secondary

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5
Q

primary or secondary: BM, Thymus

A

primary

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6
Q

primary or secondary: spleen, lymph nodes, MALT, GALT

A

secondary

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7
Q

B lymphocytes are mediators of __
immunity

A

humoral

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8
Q

T lymphocytes are mediators of __
immunity

A

cell-mediated

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9
Q

antigen presenting cells (4)

A

dendritic cells
macrophages
b-cells
follicular dendritic cells

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10
Q

morse: natural killer cells are similar looking with lymphocytes. both cells have surface markers.

A

tf (nk is parang lympho but w/o surface markers)

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11
Q

MHC class found in dendritic cells

A

MHC class 2

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12
Q

t/f: all APCs present processed antigens to t-helper cells

A

f (follicular dendritic cells present processed antigens to b cells)

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13
Q

functions as chemical signals

A

cytokines

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14
Q

cytokines are produced mainly by __ cells. these can also be produced by __ cells and __

A

immune cells, endothelial cells, fibroblasts

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15
Q

effector cells (3):

A

t lymphocytes
macrophages
granulocyts

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16
Q

type of phagocytosis of neutrophils

A

frustrated phagocytosis

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17
Q

type of phagocytosis of monocytes / macrophages

A

sustained / facilitated

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18
Q

neutrophil chemotactic factors (5)

A

bacterial lipoteichooc acid
c’ peptide (c5a)
leukotriene b4
mast cell derived chemotactic peptide
neutrophil chemotactic peptide (IL8)

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19
Q

monocyte / macrophage chemotactic factors (4)

A

transforming growth factors b
monocyte chemotactic protein 1
RANTES
macrophage inflammatory protein

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20
Q

toll like receptors are present in __

A

monocytes / macrophages

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21
Q

professional APC

A

dendritic cells

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22
Q

Smallest granulocyte; Stimulate B cell to produce
antibodies

A

basophil

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23
Q

Has phagocytic action; First line of defense against helminthic infection; Regulates the immune response

A

eosinophil

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24
Q

effector function of t helper cells

A

cytokine production

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25
Q

effector function of t helper cells

A

direct killing

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26
Q

CD marker surrounded by sheep rbc; rosette formation

A

CD2

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27
Q

neutrophil distribution

A

circulation & marginating pools

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28
Q

monocyte distribution

A

blood circulation

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29
Q

macrophage distribution

A

tissues

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30
Q

opsonin receptors present in neutrophils, monocytes, and macrophages

A

FcyR
CR1
CRP

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31
Q

neutrophil life span

A

short-lived

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32
Q

monocyte/macrophage life span

A

long-lived

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33
Q

with abundant fc epsilon receptors

A

mast cells

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34
Q

receptor where IgE binds

A

FC epsilon receptor

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35
Q

APC that has the most number of MHC class 2

A

dendritic cell

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36
Q

dendritic cells are capable of __ or cross-presentation

A

cross priming

37
Q

t/f: dendritic cells have both MHC class 1 and class 2 molecules

A

t (for cross-priming)

38
Q

organelles important in cross-priming

A

proteosomes

39
Q

2 types of dendritic cells

A

classical/conventional
plasmacytoid

40
Q

type of DC that resembles plasma cells and are able to release cytokines (e.g. type 1 - interferon)

A

plasmacytoid

41
Q

third population cells / large granular lymphocytes

42
Q

t/f: nk cells kills target even without prior exposure

43
Q

CD markers of NK cells

A

CD16, CD56

44
Q

CD marker of NK cells associated with ADCC

45
Q

ADCC

A

Antibody dependent cell-mediated cytotoxicity

46
Q

receptors of NK cells: killer inhibitory

A

KIR
CD94/ NKG2A

47
Q

receptors of NK cells: killer activation

48
Q

virally infected cells express __ and __

A

micA, micB

49
Q

which nk receptor is activated when there is no virus in the cell

50
Q

stronger and faster response of lymphocytes when encountering the same antigen for the 2nd time

A

anamnestic response

51
Q

t-cell differentiation: cells that enters the corticomedullary junction and moves toward the cortex where TCR receptors starts to form

A

prothymocytes/ t-lymphocyte precursor

52
Q

t-cell differentiation: random rearrangement in the gene occurs to code for the TCR

A

pro-t cells / double negative thymocytes

53
Q

t-cell differentiation: positive and negative selection occurs

A

pre-t cells / double positive thymocytes

54
Q

CD marker associated with TCR

55
Q

t/f: in the selection process of pre-t cells, TCR must react to your antigen for it to be saved and positively selected

A

f (negative selection if nagreact, positive if di nagreact)

56
Q

t/f: class 1 and 2 molecules play an important role in the selection process of pre-t cells

A

t (if recognized by class 1, CD8; if recognized by class 2, CD4)

57
Q

CD4/CD8: direct killing

58
Q

CD4/CD8: cytokine production

59
Q

Th(1,2,17, or reg): activates macrophage

60
Q

Th(1,2,17, or reg): activates b cells

61
Q

Th(1,2,17, or reg): regulates immune response

62
Q

CD marker of memory cells

63
Q

b-cell differentiation: rearrangement of genes occur which codes for heavy and light chains of BCR

A

pro-b cell

64
Q

t/f: light chains are formed first than heavy chains

65
Q

b-cell differentiation: genes formed are used to form chains (heavy & light)

A

pre-b cell

66
Q

b cell differentiation: surface immunoglobulin is formed, IgM complete

A

immature B cell

67
Q

t-lymph % in the blood

68
Q

b-lymph % in the blood

69
Q

t/f: plasma cells are rich in RER

70
Q

plasma cells have prominent __ nucleus; __ appearance

A

eccentric, wagon wheel

71
Q

plasma cells have specialized golgi apparatus at __ region

A

hoff region (pale/halo-like area)

72
Q

memory b cells cd marker

73
Q

counterpart of BM in animals

A

bursa fabricius

74
Q

bilobed organ; site of development of functional t-cells; undergoes physiologic atrophy

75
Q

IL7 may be produced by thymus cells also known as

A

hassl corpuscles / thymic cortical epithelial cells

76
Q

capsulated organs

A

spleen & lymph nodes

77
Q

collecting points of lymphatic fluid; filters lymph of its impurities

A

lymph node

78
Q

cells found in the cortex of lymph nodes

79
Q

cells found in the paracortex of lymph nodes

A

T cells, APCs

80
Q

cells found in the medulla of lymph nodes

A

plasma cells

81
Q

t/f: the secondary follicles at the cortex are has a germinal center called the germinal center of flemming

82
Q

primary / secondary follicle: primed, activated b cells

83
Q

primary/secondary follicle: resting “naive” b cells

84
Q

process if how lymph moves from blood to a particular tissue

85
Q

2 types of splenic tissue

A

red pulp
white pulp

86
Q

cells found in periarteriolar Lymphoid Sheath (PALS)

87
Q

cells found in the primary follicle of the spleen

A

unstimulated b cells

88
Q

cells found in the marginal zone of the spleen

A

dendritic cells, APCs

89
Q

cytokines promoting chemotaxis

A

chemokines

[3Y2S] - MT6326 SERO (4 decks)

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