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Pharma HLS > Lec 3 > Flashcards

Lec 3 Flashcards

1
Q

What is the mechanism of antitrombin 3?

A

Inhibit thrombin from coagulation

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2
Q

Does warfarin coagulation or antixcoagulation factor ?

A

It is anti-coagulation factor but in firs 36 hours it may cause thrombosis

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3
Q

What warfarin cause thrombosis in first 36 hours ?

A

Due it it I hip it protein c and protein s

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4
Q

Does estrogen increase or decrease coagulation?

A

Increase it

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5
Q

Which coagulation pathway is faster ?

A

Extrinsic pathway

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6
Q

Prothrombin test used 5o detect any pathway ?

A

Extrinsic pathway

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7
Q

PTT used to detect any pathway of coagulation?

A

Intrinsic pathway

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8
Q

When we give heparin, we used any test to detect if it is normal or not ?

A

PTT

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9
Q

When we give warfarin we used any test to detect if there any abnormalities in blood clotting .

A

PT

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10
Q

What is the factor the affected by heparin?

And what is factor affected by warfarin?

A

12,11,19,9,2

10,9,7,2

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11
Q

What is the product that come from fibrinolysis?

A

D-dimmer

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12
Q

What is the orally anticoagulant drug?

A

Warfarin & dicumarol

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13
Q

What is the parenteral anticoagulant drug?

A

Heparin & hirudin

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14
Q

Does heparin have direct or indirect effect on coagulation factor?

A

Indirect because it inhibit this coagulant by activation anti-coagulant factors

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15
Q

Does hirudin & lepirudine have direct or indirect effect on coagulation?

A

Have direct effect by inhibit this coagulants factors

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16
Q

Oral anticoagulant drug dependence on?

A

Vitamin k

17
Q

How oral anticoagulant drug acts?

A

By inhibit =it’s in k epoxied reductase enzyme , so it prevent carboxylation of factor 2,7,9,10 so it not activated

18
Q

Does warfarin given to pregnancy women ? And what is the anticoagulant drug given to it ?

A

No because it cross placenta and we used standers or low molecular weight heparin

19
Q

Does warfarin inhibit activation of vitamin k depending factor that found in blood ?

A

No , it prevent formation of this factor but other factor that found in blood befor given warfarin is still effect

20
Q

What is the antidote of warfarin?

A

If there minor bleeding we give patient vitamin k but if it sever bleeding we give fresh frozen plasma
Buuuut the most important is fresh frozen plasma

21
Q

Does aspirin increased or decrease activity of warfarin?

A

Increased it

22
Q

What is the drug-drug interaction between aspirin/phenylbutazone and warfarin ?

A

This drug replacement warfarin from albumins so it increased activation of warfarin. Also, it prevent platelet aggregation so it synergism with warfarin

23
Q

What is the interaction between antibiotics & warfarin?

A

If antibiotics kill normal flora it can reduced vitamins k so warfarin activation increased
Also it may inhibit metabolism of warfarin so increase activation of warfarin

24
Q

What is the interaction between barbiturates/rifampin and warfarin?

A

This two drug induced the metabolism of warfarin so it decreased its activity

25
Q

What is the antidote of heparin & LMWH ?

A

any thing have positively charge such as protamine sulfate

26
Q

What is the mechanism of heparin?

A

It activate anti-coagulant factors specially antithrombin 3

27
Q

Does heparin affected coagulation factor that found in blood before given heparin?

A

Yes because it affected anticoagulant conversely warfarin not inhibit it because it affected liver

28
Q

What is the activation of heparin on lipid ?

A

It increased lipoprotein lipase which destruction LDL

29
Q

What is the administration of heparin?

A

IV or SC , nooooot given IM

30
Q

Which is have longer half life , heparin of LMWH?

A

LMWH

31
Q

What is the adverse effect of heparin?

A

-bleeding, -thrombocytopenia, -hypersensitivity , -alopecia, -osteoporosis, -thrombosis

32
Q

When heparin caused thrombosis?

A

When we used it continuously

33
Q

What is contraindications to heparin?

A

Hemophilia, thrombocytopenia,hypertension , with aspirin, befor and after brain or eye surgery , aminoglycoside because it have positively charge

34
Q

What is the anti-coagulant drug which given parenteral and affected directly

A

Hirudin , lepirudin , dabigatran , argatroban

35
Q

What is the rout of administration of hirudin , lepirudin , dabigatran , argatroban

A

IV

Pharma HLS (3 decks)

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