Lec 2 treatment of TB and covid:

Question 1

Clinical presentation of TB in NON HIV infected patient:

Answer 1

malasie
anorexia and wieght loss
cough
fever
night sweats

Question 2

First line tuberculosis treatment:

Answer 2

Ethambutol
Isoniazid
rifampin
pyrazinimamide

Question 3

two treatments of LTBI that resolves in 3 months:

Answer 3

Isoniazid and Rifampin daily

Isoniazid and rifapentine weekly
CDC recommended.

Question 4

treatment that resolves in 4 months:

Answer 4

daily rifampin

Question 5

Active form of TB treatment and how long it takes and what can be added to it:

Answer 5

9 months of isoniazid and rifampin

can add pyrazinamide AND ethambutol for the first 2 months—— treatment reduced to 6 months.

Question 6

Streptomycin, kanamycin,amikacin

(aminoglycosides) used for:

Answer 6

Multidrug resistant TB

Question 7

Capreomycin used for

Answer 7

multidrug resistant TB

Question 8

Levofloxacin,moxifloxacin

(fluoroquinilones) used for:

Answer 8

Multi drug resistant TB

Question 9

Any first line active drugs++ Cycloserine,ethionamide,p-aminosalicyclic acid treat what

Answer 9

MDR

Question 10

Clofazimine and linezolid

Answer 10

for extensive drug resistance TB
(XDR TB)

Question 11

Bedaquiline, pretomanid and linezolid is for:

Answer 11

most promising shorter regimens for MDR TB.

6 months

Question 12

Initial treatment for pregnant female with TB:

Answer 12

Isoniazid, Rifampin and ethambutol for 9 months

Question 13

vitamin B6 is given to patient with risk of neuropathy, and these patients are:

Answer 13

-pregnant
-breastfeeding infants
-person with HIV
-diabetes,chronic renal failure,alcoholism
-extreme ages

Question 14

Adverse reactions of Isoniazid:

Answer 14

Allergic reactions: fever, skin rash, Drug induced SLE

Direct toxicity:
-INH-induced hepatitis (most common)
-CNS toxicity
-periphral neuropathy (B6)

Question 15

Rifa and its derivatives:

Answer 15

first line oral agents

Question 16

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Can be used as an alternative to isoniazid:

Answer 16

Rifampin

Question 17

Adverse reactions of rifampin:

Answer 17

-harmless orange color to bodily secretions
-rashes, thrombocytopenia, nephritis
-jaundice and hepatitis

Question 18

mycobacterial Arabinosyl transferase inhibitor:

Answer 18

Ethambutol

Question 19

most mild COVID is managed with:

Answer 19

acetaminophen and ibuprofen

Question 20

Antivirals: patients highly susceptible to strong covid:

1)Nirmatrelivir with ritonavir

Answer 20

Nirmatrelvir acts as an orally active 3C like protease inhibitor

Question 21

2)Remedisivir:

Answer 21

-adenosine analoge
-binds with viral RNA-dependant RNA polymerase and inhibits viral replication

Question 22

3)molnupiravir:

Answer 22

-inhibitor of RNA dependant RNA polymerase acting like a ribonucleoside analog for RNA polymerase

Question 23

Drugs For severe hospitalized patients with COVID 19:

Answer 23

-dexamethasone
-remdesivir
-theraputic anticoagualtion

Question 24

Patients that are in severe need of oxygen receive:

Answer 24

-Dexamethosone
-Baricitinib
-IV tocilizumab
-prophylactic heparin dose

REMDISEVIR NOT GIVEN IN MECHANICAL VENTILATION PATIENTS

Question 25

Blocker of JAK1 and JAK2:

Answer 25

Baricitinib

Question 26

anti-IL-6 receptor monoclonal antibody

Answer 26

Tocilizumab