Lec 2 Exam 1 Flashcards
what is EC50
the dose of drug that produces 1/2 maximal effect
what is the dose response curve
the quantitative representation of the pharmacological effect
what are partial agonists
agonists that are poor at activation that their best is not good enough to achieve the max effect that other agonists can achieve
what is drug efficacy
the ability of a drug to confer a response
what is drug potency
the concentration range where it works
what are receptor gene families
excitatory and inhibitory
what is the law of mass action equation
change = {k (R) (D)}/ {EC50 + D}
can EC50 be less than Keq?
yes
why are EC50 and Keq different
bc sometimes a drug produces half the maximal effect at less than half maximal binding thus EC50 can be less or equal to Keq
name two types of agonists
full and partial
what is drug potency determined by
its binding affinity and efficacy
why are receptor gene families important
bc drugs can elicit different effects in different contexts
