Lec 1 Exam 1

Question 1

drugs bind to what

Answer 1

receptor (protein)

Question 2

define agonists

Answer 2

produce a physiological effect when binding to a receptor

Question 3

define antagonists

Answer 3

block action of agonists

Question 4

what does a binding curve of drug bound to receptor vs free drug concentration look like

Answer 4

rectangular hyperbola

Question 5

define dissociation constant

Answer 5

concentration of drug providing half of receptor max binding

Question 6

what do pilocarpine and atropine bind to to produce their effects

Answer 6

they bind to muscarinic acetylcholine receptor protein of salivary glands

Question 7

what is the dissociation constant formula

Answer 7

Kd= {(R) *(L)} / (RL)

Question 8

what is the interaction of a drug with a receptor based on

Answer 8

law of mass action

Question 9

why might 2 drugs require different concentrations to achieve the same effect

Answer 9

bc the 2 drugs have different dissociation constants

Question 10

will twice the amount of a drug have twice the effect

Answer 10

NO