Lec 1 - GI tract Flashcards
what is an essential nutrient?
component of food deemed to be essential to life & physiological functions
what happens if the diet lacks essential nutrients?
results in physiological dysfunction, impaired growth, impaired reproductions &/or organismal demise
what is metabolism?
refers to the chemical conversions that occur with the cell & their associated changes in energy “the chemistry of life”
what is nutrition?
refers to how an organism acquires adequate nutrient intakes to facilitate physiological function
what are the essential nutrients (“required for life”)?
energy, certain fatty acids & amino acids, vitamins; minerals
True or False: Carbohydrates are an essential nutrient
Flase: carbohydrates are not an essential but can contribute essential energy
what macromolecules are our bodies composed of?
lipids, proteins, nucleic acids, & carbohydrates
True or False: we cannot synthesize these macromolecules from nothing
true
what micronutrients are essential components of food?
vitamins & minerals
what are vitamins & minerals required for?
as cofactors & substrates in metabolic reactions, important signaling molecules, and influence cellular homeostasis through several mechanisms
what must our digestive tract to for cell to absorb nutrients?
be able to break down food components into their minimally absorbable forms
the digestive system ecology and immunotolerance:
the digestive tract is in contact with the outside world & a huge ecosystem of microorganisms & how the immune system can sense a friend vs foe
the digestive system cell proliferation:
the digestive tract rapidly turns over, maintaining a high proliferative capacity for decades
fundamental for understanding pathways such as the Wnt signaling pathway
the digestive system neurobiology:
vagus nerve allows coordination between brain & gut
What organs are in the GI tract?
oral cavity
esophagus
stomach
small intestine
large intestine
anus
Of the organs in the GI tract which is an accessory?
oral cavity
what other organs form part of the small intestine
liver gallbladder pancreas
what is digestion?
physical & chemical -> reduce size of molecules & repackage to facilitate absorption
what is absorption?
movement from GI tract to blood or lymph
what is secretion?
movement into lumen of GI tract
what is motility?
muscles mix & move contents via peristalsis
what is barrier
between external & internal environments
how does the GI tract keep itself organized?
by having layers, made of several issue types, contains different cell types
what are common layers of the GI tract
mucosa
submucosa
muscularis
adventitia (esophagus) or serosa (stomach, intestine)
what are the different tissue types of the GI tract
epithelia
connective
vascular
lymphatic
muscle
nerve
epithelia tissue
various cell types responsible for secretion of hormones, enzymes
connective tissue
forms supportive structure for tissues, facilitate storage, transport & signalling
vascular tissue
facilitates absorption & transport of compounds & cells
lymphatic tissue
transports lipids, interstitial fluid; facilitates immune function
muscle tissue
smooth & striated muscle to process, mix & move food along the GI tract
nerve tissue
neural & glial cells grouped into plexuses to coordinate various gut functions
functions of the oral cavity
chewing (mastication)
initiate digestion
swallowing
what neural aspects of the oral cavity cause disease status?
disruption of neural control/coordination of bolus formation & swallowing
functions of salivary glands
chewing
initiate digestion
swallowing