Lec 03: Normal Immune Response Flashcards
True of adaptive immunity EXCEPT
A. stimulated by exposure to infectious agents
B. poised to respond rapidly to infections
C. increases in magnitude with successive exposure
D. responds to non-microbial antigen
E. NOTA
B.
Adaptive immunity responds slower and takes 1-5 days after infection.
The following are components of innate immunity EXCEPT
A. physical barriers B. neutrophils, macrophages, and natural killer cells C. complement system D. cytokines E. NOTA
E. NOTA
T/F
The diversity of innate immunity is limited and produced by somatic recombination of gene segment.
F
Innate immunity is limited and germ-line encoded.
Adaptive immunity is very diverse and exhibits somatic recombination.
T/F
Both innate and adaptive immunity exhibit non-reactivity to self.
T
Identify
Administration of vaccine against this disease led to a 100% decline in cases as of the year 2000.
Polio
What cell type in adaptive immunity kills infected cells and eliminate reservoirs of infection?
A. B lymphocytes B. natural killer cells C. T cytotoxic lymphocytes D. macrophages E. AOTA
C. T cytotoxic lymphocytes
NK cells and macrophages are part of innate immunity.
B lymphocytes are non-cytotoxic.
T/F
Transfer of effector T lymphocytes confer immunologic memory.
F
Effector T cells are non necessarily memory cells.
This feature of adaptive immunity allows the immune system to respond to newly encountered antigens.
A. memory
B. specialization
C. self-limitation
D. specificity
C. self-limitation
The following are functions of activated helper T cells EXCEPT
A. activation of macrophages B. activation of complement C. activation of T lymphocytes D. activation of B lymphocytes E. NOTA
B.
Activation of complement is a function of antibodies.
Enumerate the five phases in the adaptive immune response.
recognition phase activation phase effector phase decline memory
The leukocyte with the lowest average blood cells count is
A. neutrophil B. eosinophil C. basophil D. lymphocyte E. monocyte
C. basophil
True of the immune response EXCEPT
A. Antigens are transported via post-capillary venules to the regional lymph nodes.
B. Circulating naive lymphocytes migrate into the lymph nodes.
C. Both naive T and B lymphocytes are activated in the lymph nodes.
D. Memory cells enter the circulation.
E. NOTA
A.
If picked up by venules, antigens are processed in the spleen.
If picked up by lymphatics, antigens are processed in the lymph nodes.
What is the phenotypic marker of cytotoxic T cells?
A. CD3+ CD4+ CD8- B. CD3+ CD4- CD8+ C. CD3+ CD4+ CD25+ D. CD19+ CD20+ E. CD56+
B. CD3+ CD4- CD8+
CD3+ = all T lymphocytes CD4+ = helper T cells CD8+ = cytotoxic T cells CD25+ = regulatory T cells CD19+ CD20+ = all B lymphocytes CD56+ = NK cells
T/F
Rejection of allografts is a function of cytotoxic T cells.
T
Natural killer cells produce what chemical mediator in response to IL-12 released by macrophages?
IFN-y
IFN-y activates the macrophage to kill the microbe.
Homeostasis and decline of adaptive immune response is achieved through what process?
apoptosis of lymphocyte clones
True of naive T lymphocytes EXCEPT
A. high levels of surface peripheral lymph node homing receptors
B. high levels of chemokine receptor CCR7
C. high levels of adhesion molecules
D. small and has scant cytoplasm
E. NOTA
C.
Naive lymphocytes should have LOW levels of adhesion molecules since they need to home in to peripheral lymph nodes. Effector T cells are the one with high levels of adhesion molecules since they need to adhere to tissues and surfaces.
Liver macrophages are called
Kupffer cells
How many macrophages are circulating per microliter of blood?
None
Macrophages are called monocytes when they are still in the blood vessels.
NK cells come from what hematopoietic progenitor?
A. myeloid B. lymphoid C. erythroid D. A and B E. NOTA
B.
B cells, T cells, and NK cells come from a lymphoid progenitor.
T/F
HIV can be transmitted even without abrasion, damage, or contact with vessels.
T
HIV may attack intraepidermal lymphocytes.
Which of the following antigen-binding molecules allows binding of conformational determinants?
A. immunoglobulins B. T cell receptors C. MHC molecules D. A and B only E. AOTA
A.
Only immunoglobulins can bind conformational determinants of antigens. Others bind only linear determinants or linear residues of peptides.
True of immunoglobulin A EXCEPT
A. monomer in serum B. dimer in mucosal secretions C. found in naive B lymphocytes D. A and B only E. AOTA
D.
IgD is the one found in naive B lymphocytes.
This is the largest and most efficient antibody type.
IgM
This is the most common antibody type.
IgG
