Learning Health System: Integrating clinical research and practice Flashcards
Definition of Learning Health System
Knowledge generation processes are embedded in daily practice to produce continual improvements in care
Definition of routinely collected data
From electronic health record systems and data registries
Definition of specific research data
From clinical trials and research
Definition of actionable data
When scientific findings => actionable knowledge
What is a Learning Health System
Data produced from research used to generate and refine current health practices for continuous improvement in health care
All about pooling of knowledge
What are the 3 processes in a Learning Health System
Routinely and securely aggregate data fro disparate sources
Convert data => knowledge
Disseminate knowledge in actionable forms to all who can benefit from it
Each problem will be addressed and improved at different rates
What is routinely collected data
What are the advantages and disadvantages of routinely collected data
From electronic health record systems and data registries
Wide coverage
Vast quantity
Quality can be an issue when a specific patient profile is needed for a precise study
What is specific research data
What are the advantages and disadvantages of specific research data
From clinical trials and research
High quality data
Controlled populations included
Well defined questions
Data is expensive and hard to get
From restricted populations
What is actionable data
What are the advantages
Routinely collected data and specific research data analysed and becomes actionable data => usable knowledge
Usable in clinical practise
Used in decision making
What are the challenges with clinical trials
Too expensive and difficult to run
Efficacy effectiveness gap
However implementation => LHS provides clinical context
What is the efficacy effectiveness gap (EEG)
Disconnect between clinical trial outcomes and info obtained from clinical practice
Interaction of drug effect with real life contextual factors which are hard to identify
How would you integrate LHS with a clinical trial
Eligibility checks done automatically from EHR data
eClinical Research Form filled based on EHR info
If patient eligible, may consent to take part in trial
All collected data is stored in EHR system and research database
What are the benefits of integrating LHR with clinical trials
eCRF data adds to EHR
Helps clinician
Data shared will benefit many patients
Can also be used for observational trials
What is the TRANSFoRm Project
Develops methods, models, services, demonstrations to support
- Epidemiological research with GP records including genotype phenotype studies and other record linkages
- Clinical trials embedded in the EHR
- Decision support for diagnoses
What are the benefits of integrating LHR with decision support systems
Uses info entered by HCW and provides a list of possible diagnoses
Data based off data from research or HR
