LE2 Flashcards
- Oogenesis occurs in which kind of ovary?
A. Fetal
B. Infantile
C. Adult
D. Atrophic
a. Fetal
Explanation: Oogenesis begins in the female fetus (fetal ovary) before birth. The process starts with the formation of oogonia, which then enter meiosis to become primary oocytes. These primary oocytes are arrested in prophase I of meiosis until puberty.
- Spermatogenesis occurs in which of the following structures?
A. Glans Penis
B. Scrotum
C. Inguinal canal
D. Seminiferous tubules
D. Seminiferous tubules
Explanation: Spermatogenesis, the process of sperm production, occurs in the seminiferous tubules of the testes. This is where spermatogonia divide and differentiate into mature spermatozoa.
- Which of the following statements about the process of gametogenesis is CORRECT?
A. The primordial germ cells are derived from the ectoderm in the yolk sac.
B. Both primary oocytes and primary spermatocytes are arrested in prophase 1 at birth.
C. Two meiotic divisions are necessary to produce haploid gametes.
D. At the completion of meiosis I, mature gametes are formed.
C. Two meiotic divisions are necessary to produce haploid gametes.
Explanation: Both oogenesis and spermatogenesis involve two meiotic divisions to reduce the chromosome number by half, resulting in haploid gametes (sperm and ova), which is essential for sexual reproduction.
- Oogonia and Spermatogonia are specialized primordial germ cells which share the following developmental milestones EXCEPT
A. Both undergo mitosis in utero.
B. Both undergo 2 meiotic divisions to produce mature gametes.
C. Both discard excess genetic material in the form of polar bodies.
D. Both complete the diploid number of chromosomes at the time of fertilization
C. Both discard excess genetic material in the form of polar bodies.
Explanation: This statement is true only for oogonia/oocytes. During oogenesis, the oocyte discards excess genetic material in the form of polar bodies to retain most of the cytoplasm in the egg. Spermatogonia/spermatocytes do not form polar bodies; instead, they undergo spermatogenesis to produce spermatids, which then differentiate into spermatozoa.
- Undergoes 2 meiotic divisions to produce haploid spermatids
A. Primary spermatocyte
B. Secondary spermatocyte
C. Spermatid
D. Spermatozoa
A. Primary spermatocyte
Explanation: Primary spermatocytes undergo two meiotic divisions to produce haploid spermatids. The first meiotic division (Meiosis I) produces two secondary spermatocytes, and the second division (Meiosis II) produces spermatids, which are haploid cells that will mature into spermatozoa.
6.Undergoes a series of complex steps from acrosome formation to development of flagellum
A. Primary spermatocyte
B. Secondary spermatocyte
C. Spermatid
D. Spermatozoa
C. Spermatid
Explanation: Spermatids undergo a series of transformations known as spermiogenesis, which includes the formation of the acrosome and the development of the flagellum, ultimately maturing into spermatozoa.
- The stage of development which are stored in the caudal epididymis
A. Primary spermatocyte
B. Secondary spermatocyte
C. Spermatid
D. Spermatozoa
D. Spermatozoa
Explanation: Mature spermatozoa are stored in the caudal (tail) portion of the epididymis, where they gain motility and the ability to fertilize an ovum.
- A 25 year-old patient comes today because she suspects she might be pregnant. Menses are every 28 days and her LMP is December 8, 2021. What diagnostic exam should be done first ?
A. Urine HCG test
B. Complete blood count
C. Serum Estradiol
D. Serum TSH
A. Urine HCG test
Explanation: The first diagnostic test to confirm pregnancy is usually a urine human chorionic gonadotropin (HCG) test, which can detect the presence of the hormone HCG, produced after implantation.
- A pregnant woman shows a serum pregnancy test to be positive; her last menses was 21 days ago, in what part of the reproductive tract will the conceptus be at this point?
A. In the infundibular area of the tube
B. Distal third of the fallopian tube
C. Near the cornual portion of the tube
D. In the upper portion of the uterine cavity
D. In the upper portion of the uterine cavity
Explanation: By the time a pregnancy test is positive (typically a few days before the missed period or about 14 days post-ovulation), the conceptus (now likely a blastocyst) would have already traveled through the fallopian tube and implanted in the uterine lining, or endometrium.
- A pregnant woman is already on the 5th week of her pregnancy, how should this conceptus be called
A. Zygote
B. Blastocyst
C. Embryo
D. Fetus
C. Embryo
Explanation: From the end of the 2nd week to the end of the 8th week after fertilization, the developing human is referred to as an embryo. After this period, from the 9th week until birth, it is called a fetus.
11.A G2P1 patient comes in for consult on her 20th week of pregnancy. What should the conceptus be called at this time ?
A. Fetus
B. Embryo
C. Blastocyst
D. Zygote
a. fetus
Explanation: After the 8th week of pregnancy until birth, the developing human is referred to as a fetus.
- Which of the following statements about gametogenesis is TRUE?
A. Initiation of Meiosis 1 occurs at puberty.
B. At the end of Meiosis 2, there are 4 haploid gametes are formed for both the males and the females.
C. Completion of the 2N occurs at fertilization.
D. Production of mature gametes is a staggered process and produces a finite number of mature
C. Completion of the 2N occurs at fertilization.
Explanation: The completion of the diploid number (2N) of chromosomes occurs at fertilization when the haploid sperm and egg nuclei fuse, restoring the diploid number of chromosomes in the zygote.
- Genetic diversity is ensured by which of the following processes?
A. Activation of G1 in the cell cycle.
B. Separation of sister chromatids in the mitotic phase.
C. Pairing of homologous chromosomes in meiosis.
D. Cytokinesis
C. Pairing of homologous chromosomes in meiosis.
Explanation: Genetic diversity is ensured through the process of meiosis, specifically during the pairing and subsequent recombination of homologous chromosomes, which allows for genetic variation.
- Refers to the one cell stage of the fertilized ovum after pronuclear membrane breakdown but before first cleavage occurs
A.Zygote
B.Morula
C.Conceptus
D.Embryo
A. Zygote
Explanation: The zygote is the one-cell stage that exists after the sperm and egg nuclei have fused but before the cell begins to divide (cleavage).
15 A ball of cells comprising the early embryo that produces the embryo, the placenta and membranes
A.Zygote
B. Morula
C.Conceptus
D.Embryo
B. Morula
Explanation: The morula is an early stage in embryonic development, a solid ball of cells resulting from the division of the zygote before the formation of the blastocyst. The term you might be looking for that encompasses the development of the embryo, placenta, and membranes more accurately might be the blastocyst, which forms after the morula stage. However, based on the options provided and the description, “morula” is the closest, although the description fits the blastocyst stage better, where differentiation into embryonic and extra-embryonic structures begins.
16 Fertilized oocyte and its derivatives at all stages of development from fertilization until birth
A. Zygote
B. Morula
C. Conceptus
D. Embryo
C. Conceptus
Explanation: The term “conceptus” refers to the fertilized oocyte and all of its derivatives (including the embryo, fetus, and associated membranes) at all stages of development from fertilization until birth.
17 What is the process wherein germ cells undergo a complex series of divisions to give rise to oocytes ?
A. Gametogenesis
B. Oogenesis
C. Ovulation
D. Fertilization
B. Oogenesis
Explanation: Oogenesis is the process by which the female germ cells undergo a series of divisions to produce mature oocytes (eggs).
- What is the transformation of round spermatids arising from the final division of meiosis Il into spermatozoa?
A. Gametogenesis
B. Spermatogenesis
C. Spermiogenesis
D. Spermiation
c. Spermiogenesis
Explanation: Spermiogenesis is the process by which round spermatids are transformed into mature spermatozoa. This process involves the formation of the acrosome, condensation of nuclear material, and development of the tail.
- The initiation of Meiosis 1 during spermatogenesis is dictated by
A. Testosterone
B. Aldosterone
C. Estradiol
D. Progesterone
A. Testosterone
Explanation: The initiation of meiosis I during spermatogenesis is influenced by testosterone, which is produced by the Leydig cells in the testes.
- Which of the following statements about oogenesis is TRUE?
A. The maximal oogonial content of the ovary is at 12-14 weeks age of gestation.
B. At birth, the female fetus has approximately 2-4 million primary oocytes.
C. The pool of oocytes are constantly replenished during every menstrual cycle.
D. Oocyte depletion only occurs at puberty.
B. At birth, the female fetus has approximately 2-4 million primary oocytes.
Explanation: At birth, the female fetus has already formed all the primary oocytes she will ever have, numbering approximately 2-4 million. These oocytes are arrested in prophase I of meiosis and decrease in number throughout the female’s life until menopause.
- A newly married couple is planning to conceive. Both do not have vices, and the female has regular 28 day cycles. If the woman reveals that her last menses was January 15, 2022. When would you predict ovulation to occur?
A Between Jan 15-20
B. Between Jan 21-25
C. Between Jan 26-31
C. Between Jan 26-31
Explanation: In a typical 28-day menstrual cycle, ovulation usually occurs about 14 days before the start of the next menstrual period. If her last menses started on January 15, ovulation would likely occur around January 29.
- A 25 y.o single woman with regular cycles, complains that she felt a fleeting, tolerable, pricking pain at her right lower quadrant associated with pelvic fullness two weeks before her expected menses. You explain that this is probably
A. Appendicitis
B. Ovulation
C. Fertilization
D. Implantation
B. Ovulation
Explanation: The symptoms described are consistent with mittelschmerz, a term used to describe the pain sometimes associated with ovulation. This typically occurs in the middle of the menstrual cycle, about two weeks before the expected menses.
23.A newly married couple followed your advice regarding timing of coitus during her fertile days. She came back after a month and reports that her period is delayed. What information is necessary to obtain at this point?
A. Age at Menarche
B. Exact day of coitus
C. Last menstrual period
D. Past menstrual period
C. Last menstrual period
Explanation: The most critical piece of information to obtain is the date of her last menstrual period (LMP). This helps in calculating the gestational age of the pregnancy and determining the next steps in care.
- A 27 yo, G1P0, comes in for consult at her 8th week of pregnancy. Which of the following statements will hold true at this stage of the pregnancy?
A. This coincides with the expected day that menstruation is expected to come
B. This coincides with the time that HCG is detectable only by a blood exam.
C. This is the time that organogenesis commences.
D. This is the time that organogenesis is complete.
D. This is the time that organogenesis is complete.
Explanation: By the 8th week of pregnancy, all major organs and external body structures have begun to form, marking the completion of the organogenesis phase. The embryo has developed into a basic structure of what will become a newborn. The details provided, such as bones beginning to replace cartilage, the formation of fingerprints, and the ability to begin hearing, indicate significant development that aligns more closely with the completion of organogenesis rather than its commencement.
25.A patient on her 10th week of gestation is complaining of nausea and vomiting. This is attributable to rising levels of which hormone?
a. FSH
b. LH
c. HCG
d. Prolactin
c. HCG
Explanation: Nausea and vomiting in early pregnancy, often referred to as “morning sickness,” are commonly attributed to rising levels of human chorionic gonadotropin (HCG), a hormone produced by the placenta after implantation.
- You are advising a pregnant patient that total duration of a normal pregnancy is computed to be:
A. 9 calendar months
B. 280 days
C. 37 completed weeks
D. 3 trimesters
B. 280 days
Explanation: A normal pregnancy is typically calculated as 280 days, 40 weeks, or 10 lunar months from the first day of the last menstrual period (LMP), which is roughly equivalent to 9 calendar months but more precisely defined in days or weeks.
- Fertilization occurs in what part of the fallopian tube?
A. Fimbria
B. Ampulla
C. Isthmus
D. Uterotubal junction
B. Ampulla
Explanation: Fertilization most commonly occurs in the ampulla, the widest section of the fallopian tube, where the sperm meets the egg.
- At the time of ovulation, in which stage of oogenesis would the oocyte be?
A. Prophase I
B. Prophase Il
C. Metaphase II
D. Metaphase I
C. Metaphase II
Explanation: At the time of ovulation, the oocyte is arrested in metaphase II of meiosis. It will only complete meiosis II if fertilization occurs.
- At the time of fertilization, which of the following statements about oogenesis is TRUE?
A. There is a temporary arrest at prophase I
B. There is a temporary arrest at metaphase Il
C. There is rapid mitotic multiplication of germ cells
D. There is completion of second meiotic division
B. There is a temporary arrest at metaphase II
Explanation: At the time of fertilization, the secondary oocyte, which is released during ovulation, is arrested in metaphase II. Fertilization triggers the completion of meiosis II, leading to the formation of a mature ovum and the expulsion of a second polar body. This process ensures that the ovum has the correct haploid number of chromosomes before it combines with the haploid sperm to restore the diploid number at fertilization.
- Which of the following statements BEST describes the embryonic period
A. It coincides with the detection of serum beta HCG
B. It commences at the third week after fertilization and lasts up to 8W
C. Organogenesis is completed
D. Coincides with the time the fetal heart is detected
B. It commences at the third week after fertilization and lasts up to 8W
Explanation: The embryonic period is defined as the time from the third week after fertilization until the end of the 8th week, during which all major organs and structures begin to develop.
- This process involves the regulation of paracrine interactions between the blastocyst and endometrium and must occur between days 20-24 of the cycle.
A. Ovulation
B. Fertilization
C. Apposition
D. Implantation
D. Implantation
Explanation: Implantation involves the blastocyst attaching to and embedding within the endometrium. This critical process typically occurs about 6-10 days after fertilization, which corresponds to days 20-24 of a typical menstrual cycle.
32.A pregnant woman is consulting for prenatal care. You proceed to obtain her Last Menstrual Period (LMP) so that you may establish
A. Conceptional age
B. Gestational age
C. Menarche
D. Coitarche
B. Gestational age
Explanation: Gestational age is calculated from the first day of the last menstrual period (LMP) and is used to monitor the pregnancy and estimate the due date.
33.A woman is currently being treated by her dermatologist for severe acne with retinoic acid. She is 6 weeks pregnant and comes to see you for advice regarding her anti acne treatment. You proceed to tell her
A. No need to worry and may continue anti acne treatment.
B. She may continue treatment but at a lower dose for as long as necessary.
C. She needs to stop the anti acne treatment.
D. You will keep silent on this matter.
C. She needs to stop the anti-acne treatment.
Explanation: Retinoic acid (isotretinoin) is teratogenic and can cause serious birth defects. It is contraindicated in pregnancy, and women are advised to avoid pregnancy during treatment and for some time after the treatment has ended.
34.A first time pregnant mom is on her 5th week of pregnancy. You meticulously ask about her Medication and/ or radiation exposure for the past month because the 3rd-8th week is
A. The period of rising maternal hormones.
B. The period of organogenesis.
C. The period of organ maturation.
D. The period of detecting subchorionic hemorrhages.
B. The period of organogenesis.
Explanation: The period from the 3rd to the 8th week of pregnancy is critical for organogenesis, the formation of organs. During this time, the developing embryo is particularly vulnerable to teratogens, which can cause congenital anomalies.
- The time elapsed since the 1st day of last menstrual period and approximately 2 weeks before ovulation
A. Menstrual age
B. Ovulation age
C. Estimated date of delivery
D. All of the above
A. Menstrual age
Explanation: Menstrual age, also known as gestational age, is calculated from the first day of the last menstrual period. It includes the approximately 2 weeks before ovulation and fertilization occur.
- The transition from the embryonic period to the fetal period begins at:
A. 8 weeks after 1st day of last menstrual period
B. 8 weeks after fertilization
C. 10 weeks after fertilization
D. 12 weeks after 1st day of last menstrual period
B. 8 weeks after fertilization
Explanation: The transition from the embryonic period to the fetal period typically begins at 8 weeks after fertilization, which corresponds to 10 weeks of gestational age (since gestational age is calculated from the first day of the last menstrual period, which is approximately 2 weeks before fertilization).
- In cases of Gestational Diabetes or Diabetes Mellitus in Pregnancy, what leads to the development of Fetal Macrosomia?
A. Fetal hyperinsulinemia
B. Maternal hyperinsulinemia
C. Fetal hypoglycemia
D. Maternal hypoglycemia
A. Fetal hyperinsulinemia
Explanation: Fetal hyperinsulinemia is a response to maternal hyperglycemia. It stimulates fetal growth and fat deposition, leading to macrosomia.
- A 21 y/o patient came in at the clinic with a chief complaint of no menstrual cycle or menarche on examination, patient has a blind pouch as vagina, no pubic hair, and no axillary hair. On further investigation, karyotype showed 46 XY; ultrasound revealed absence of uterus, cervix, and fallopian tubes. This patient most likely has:
A. True hermaphroditism
B. Androgen insensitivity syndrome
C. Congenital adrenal hyperplasia
D. Klinefelter syndrome
B. Androgen insensitivity syndrome
Explanation: Androgen insensitivity syndrome (AIS) is characterized by the presence of male (46,XY) chromosomes in an individual who has female external genitalia and secondary sexual characteristics but lacks a uterus, cervix, and fallopian tubes due to resistance to the actions of male hormones (androgens).