LC Unit 3 Flashcards

1
Q

critical period vs sensitive period in development

A

critical period:

  • when development is especially responsive to influence
  • vulnerable to injury
  • rapid growth

sensitive period:

  • when development is more amenable to the aquisition of certain abilities (ex. language during 1st yr)
  • more sensitive to certain stimuli
  • more readily influenced by environmental factors that have a long term impact on development
  • exposure to such thins suffices in teaching rather thane spending conscious effort to learn (ex. foreign language)
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2
Q

factors common to numerous developmental theories

A
Biological:
-physical
-nervous
-endocrine
Motor
Cognitive
Social/emotional and personality
Language (expressive and receptive)
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3
Q

basic ideas behind the developmental theories of Freud, Piaget, Erikson, Bowlby, Bronfenbrenner, and Kohlberg

A

Freud:
-Ideas:
—Psychoanalysis
—The Oedipal Complex
—Freudian Slips
-Stages of Development:
—oral: birth to 18-24mo; sensually seeking through oral exploration
—anal: 18mo-3yo; control over toiling and masturbation; “anal traits”– compulsive, neat, retentive, stubborn
—Phallic: 3-6yo; Oedipal complex; castration anxiety or penis envy
—Latency: 5yo-puberty; temporary freedom from sexual instincts and anxieties through repression
—Genital: puberty-adult; sexual impulses no longer repressed; urges change to acceptable fulfillment of desires through loving another person
-Key terms:
—psychic apparatus parts:
===Id- underlying desires, uncoordinated trends
===Ego- organized and realistic part of your psyche
===Superego- critical and moralizing
—the unconscious
—dream interpretation

Piaget:
-Ideas:
—Cognitive development through interactions with the environment
-Stages of Development:
—Sensorimotor:
===Birth to 18-24mo
===dependence on exploration of perceptual stimuli through sensory modalities
===development of object permanence!!!
—Pre-operational:
===18mo-7yo
===understand pretend symbols
===magical explanations
===single perceptual attribute
===language development
===causality based on temporal or spatial nearness
===limited attention span and memory
===imaginary friends
===egocentrism
===can attribute 1 property to things: tall = older
—Concrete operations:
===7-12yo
===conserve volume and quantity
===reversibility of events
===causal sequences: pouring water from thin cup to fat cup = same vol
—formal operations:
===12yo-adult
===manipulation of ideas and concepts
===expansion of formal fund of knowledge
===abstract reasoning and metarecognition (allows understanding of divergent perspectives)
-Key terms:
—Assimilation: integration of new experiences w/ past experiences and problem solving based on past experiences
—Accommodation: reorganization of mind based on discordance between new experience and old experience to make sense of new experience
—Decalage: unevenness in developmental progress across different cognitive abilities (not everything develops at same rate)
—Object permanence: object is still there even if you can’t see it
—Egocentrism: toddlerhood. Adolescents- why is everyone always attention to me?

Bowlby:
-Ideas:
—Attachment Theory
===babies are evolutionarily programmed to have relationships with primary caregivers
-Stages of Development:
—Attachment
===2-7mo
===discrimination/limited preference
===differentiates among interactive partners
===may seem more comfortable with primary caregiver
===social with everyone and preferences not strongly expressed
—7-12mo
===preferred attachment becomes evident
===stranger anxiety
===separation anxiety
===development of “felt security”
===development of trust (vs mistrust)
===hierarchy of preferred caregivers
—12-20mo:
===use of attachment figure as a secure base from which to venture out and explore
===use of attachment figure as a safe haven to which to return if distressed or frightened
===proximity to caregiver promotes an internal feeling of security in infant
-Key terms:
—Secure base
===relationship w/ a person who provides comfort and safety and enables the infant/young child to explore the environment
—Strange situation
===experimental paradigm developed by Mary Ainsworth to determine attachment status

Erikson:
-Ideas:
—Identity development
—Conflicts at each stage results in formation of identity
-Stages of Development:
—Trust vs mistrust:
===infancy
===conflict resolves via relationship with loving, responsive parents
—Autonomy vs shame:
===early child/toddlerhood
===resolved through opportunities to exercise free choice and self-control with appropriate supervision
===learning rules and self-control
===willpower
—Initiative vs guilt
===preschool
===resolution leads to feelings of purpose and control
—Industry vs inferiority
===school age
===resolution leads to feelings of competency
—Identity vs role confusion
===adolescence
===resolution leads to an integrated sense of self
—Intimacy vs isolation
===early adulthood
===resolution enables feeling of love towards others
—Generativity vs stagnation
===middle adulthood
===marked by caring for others and productivity in society
—Ego integrity vs despair
===late adulthood
===wisdom
===integrity and selfhood that withstands physical deterioration

Kohlberg:
-Ideas:
—Stages of Moral Development
—(Heinz Dilemma)
-Stages of Development:
—Naive moral realism:
===action based on rules
===motivation is to avoid punishment
—Pragmatic morality:
===action based on desire to maximize reward/benefit and minimize negative consequences for self
—Socially-shared perspectives:
===action based on beliefs about approval / disapproval of others and feelings of guilt
—Social system morality:
===action based on formal dishonor and guilt about harm done to others
—Human rights and social welfare morality:
===action based on maintaining respect for community and self-respect; social values and rights
—Universal ethical principles:
===action determined by equity, fairness, and concern about maintaining personal moral principles

Bronfenbrenner:
-Ideas:
---Human ecology theory 
-Stages of Development:
---Development involves interaction between individual and the environment
-Key terms:
---microsystem: 
===immediate context for an individual (ex family, classroom)
---mesosystem:
===2 microsystems in interaction
---exosystem:
===external environment that directly influences development (ex parental workplace)
---macrosystem:
===broader social context
---chronosystem:
===evolution of external systems over time
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4
Q

3 levels of the mind as outlined by Freud

A

Id:

  • set of uncoordinated instinctual trends
  • primal urges, food, sex, aggression
  • indistinct
  • entirely subconscious
  • “I want it”

Ego:

  • organized, realistic part
  • mediator between primal urges and behavior accepted in reality
  • “take it and you will get in trouble”

Superego:

  • plays the critical and moralizing role
  • moral values
  • conscience
  • can lead to self-blame and attacks on ego
  • “You know you can’t have it. Taking it is wrong”
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5
Q

defense mechanisms as defined by Freud

A

Ego defenses:
-unconscious and mental processes used to resolve conflict and prevent undesirable feelings (anxiety, depression, etc)

Repression:
hiding away wishes in the unconscious

Displacement:
symptoms (wishes/impulses) that are hidden in one area appear in another

Sublimation:
using energy from unfulfilled wishes/impulses in a constructive way

Denial:
failure to acknowledge a truth that produces anxiety

Rationalization:
actions based on one motive justified by a more acceptable motive

Reaction formation:
displaying a trait that is the opposite of a repressed one

Projection:
Attributing your own unacceptable impulses to another

Regression:
reverting to behaviors seen in earlier stages of development to obtain care/resources that alleviate anxiety

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6
Q

types of behavior used to classify an infant’s attachment to his or her primary caregiver

A

Secure infants:

  • seek proximity, contact, and interaction w/ caregiver
  • distress at separation but are happy to see caregiver upon return
  • more readily comforted by caregiver than stranger
  • 55-65% in low risk

Avoidant infants:

  • avoid proximity to caregivers at reunion
  • treat mother the same as a stranger
  • 15-20% in low risk

Resistant infants:

  • seek proximity then reject it
  • anger toward caregiver and stranger; passivity
  • 5-10% in low risk

Disorganized/disoriented:

  • no coherent strategy
  • strange behaviors
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7
Q

4 developmental domains which are tracked across the lifespan

A

Motor
Cognitive
Social
Emotional

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8
Q

motor, cognitive, and social/emotional developmental abilities associated with each of the following age groups: newborns, infants, toddlers, preschoolers, school aged children, and adolescents

A
Newborns:
-Motor:
===feeding, sleeping, movement
-Social:
===social interaction
-Emotional:
===ability to calm themselves
Infant: 0-6mo
-Motor:
===Primary reflexes (moro, Babinski, Rooting, Sucking)
===Resolve and become increasingly purposeful 
===Habituation after repeated exposure
===Reaching (3mo), rolling (4mo), sitting up (6mo)
-Cognitive:
===visual and auditory tracking 
===imitation
===object/action patterns
===means-ends association
-Social:
===social smile (6weeks)
===unintentional babbling/cooing --> purposeful vocalization
===stranger anxiety (6mo)
-Emotional:
===surprise, sadness, fear, distress
Older babies: 6-12mo
-Motor:
===banging/shaking
===crawling
===pulling up
===standing
===walking (12mo)
===complex action patterns w/ objects
===increase fine manipulation
-Cognitive:
===sensory-motor stage:
===play games
===cause and effect
===object permanence
===language development
===can remember things/people and anticipate future events
===experience the world through their senses (Piaget's sensory-motor stage)
-Social:
===stranger anxiety peaks
===separation anxiety (8mo)
-Emotional:
===express different moods
===joint attention
===increase use of social referencing and secure base behavior
===usually a time of very positive mood
Toddler: 12-36mo
-Motor:
===Walking
===Climbing
===Running
===Hitting / Biting
===Fine motor skills ↑, use of tools
-Cognitive:
===Best way to learn is through play and social interaction.
===“No” emerges
===↑ Symbolic capacity
===Imitate novel events
===Single words and brief phrases
===Number concepts
===When/Then logic
-Social:
===Separation anxiety peaks (13mo)
===Tantrums and passions
===Low frustration tolerance
===↑ independence
===↑ ability to follow rules
===Peer play and friends
===Emotions felt 1 at a time
===Empathy and theory of mind
-Emotional:
===Routines and rituals are important. 
===Toddlers are masters at detecting differences. 
===Don’t initiate a routine you’re not willing to repeat
Preschooler: 3-6yo
-Motor:
===Jump
===Walk up stairs
===Alternating feet
===Jungle gym
===Ride a bike
===String beads
===Button/unbutton
===Scissors
===Draw a person
-Cognitive:
===Pre-operational thinking:
===Best way to learn is through play and social interaction.
===Vocab ↑ from 1000-8000 words
===Retelling/inventing stories
===Number and letter recognition
===Time telling
-Social:
===Peer relationships
===Taking turns / negotiation
===Play, gender segregation
===Imaginary friends
===Self help skills
===Ability to follow rules ↑ and participate in groups
-Emotional:
===Fears are very common
===Gender identity solidifies
===Sense of self as constant
School aged children: 6-12yo
-Motor:
===Complex gross motor tasks - sports
===↑ Fine motor skills
===Sewing, typing, pottery
-Cognitive:
===Concrete cognition:
===Logical thinking
===Deductive reasoning
===Advanced classification into hierarchies
===Seriation
===Conservation of mass, length, wt, volume
===Written expression matches verbal expression
-Social:
===Social groups
===Relationships with adults outside the family
===Rule bound behaviors
-Emotional:
===Complex emotions are experienced and described
===Perspective
Adolescents:
-Motor:
===↑ strength + endurance, higher skill levels
===Fine motor skills
-Cognitive:
===Flexible and abstract thinking
===Mental hypothesis testing
===Multiple alternatives
===Complex reasoning and problem solving
===Logical rules
===Consider combinations of factors that affect solutions
-Social:
===Peer pressure
===Dating
===Pecking orders
===Parental influence ↓ and peer influence ↑ 
-Emotional:
===Issues with peer rejection
===Sense of self is in flux
===Ask them: “What do you do with your friends?”
===With regards to sexual activity + substance use “What have you tried”
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9
Q

characterize adulthood from a developmental and milestone perspective

A

Continued development:

  • Myelinization of the central nervous system until the 5th decade
  • Complex social skills continue to improve until about age 30
  • Delay of gratification peaks at age 40
  • Physical abilities vary by age (sprinters hold records in their 20s while distance runners hold records in their 30s)
  • Cognitive abilities vary by age
  • Better driving records at age 50 than age 20
  • Suicide is a greater risk with age

Sensory:

  • Vision: declines after age 65; changes in ability to see things up close in the mid-40s
  • Hearing: loss in the 70’s with decreased perception of high frequency sounds
  • Decline in reaction time, strength and coordination
  • Taste/smell: declines, especially in men

Memory:

  • Substantial decline in recent-long term memory;
  • less impact on remote long-term memory - questionable based on future lectures where only processing time should increase and memory should stay the same.
  • Working memory decreases
  • Little change in memory span

Intelligence:

  • Crystallized intelligence (fund of knowledge) increases
  • Fluid intelligence (processing speed, reasoning speed) decreases
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10
Q

cardiopulmonary changes at birth which allow the switch from placental-based to pulmonary-based gas exchange

A

Pulmonary adaptation to extrauterine life is determined by 3 factors:

  • Lung growth & development
  • Respiratory drive
  • Physiologic maturation

Lung Growth & Development

  • Canalicular Phase:
  • –17-27 weeks.
  • –Type II cells begin to differentiate and capillary network begins to form.
  • Saccular Phase:
  • –26-36 weeks.
  • –Thinning of interstitial space allowing closer association of capillaries to air spaces and type I cells.
  • Alveolar Phase:
  • –36 weeks to 3 or more years.
  • –True alveoli present.

Take home message:
Prior to 24 weeks the capacity for ventilation is limited by lack of true air spaces and the distance of capillaries from rudimentary air spaces.
This is the limit of viability for a fetus.

Respiratory Drive:

  • Fetal “breathing” movements are inconsistent, no net movement of fluid into lungs
  • Fetal gasping occurs with asphyxia, can result in fluid aspiration (e.g. meconium aspiration) prior to birth
  • At birth, onset of regular, consistent respirations occurs in response to:
  • –Sensory stimulation: cold, light, touch, noise
  • –Mild asphyxia and hypercarbia as the blood flow to the baby is not great during contractions

Failure to Breathe

  • Primary apnea:
  • –Apnea is brief in duration
  • –Stimulation initiates cry
  • –Followed by gasping respirations
  • –HR and BP relatively maintained
  • Secondary apnea:
  • –When original gasping ceases, secondary apnea ensues;
  • –Requires positive pressure ventilation to establish lung inflation and begin regular respirations
  • –Stimulation alone is ineffective
  • –HR and BP fall quickly
  • –Death occurs without rescue ventilation
  • –Therefore, if the infant is apneic at birth, we assume it’s secondary apnea and intervene quickly

Physiologic Maturation:
Surfactant is a phospholipid-protein complex that coats the inside of air sacs and allows air to remain in the air sac on expiration called the functional residual capacity.
-Lower surface tension within air spaces.
-Prevent alveolar closure at the end of expiration.
-Composition:
—90% lipid: phosphatidylcholine + phosphatidylglycerol.
—10% protein: Proteins A, B, C, D and phospholipids are important for spreading surfactant as a mono-multilayer film and fighting infection.
—The surfactant mono-multilayer enables the formation of the Functional Residual capacity, FRC, and the ΔV / ΔP, which is the optimal compliance.
—Macrophages recycle 90%.
-Secreted by Type II alveolar cells.
—Stored as lamellar bodies.
—Extruded as tubular myelin into the airspace after fusing with cell membrane.

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11
Q

factors that modulate pulmonary vascular resistance around the time of birth

A

Normally following birth, lung expansion causes PVR to fall
Additionally, ↑ PO2, ↑ pH, ↓ PCO2, ↑ NO, ↑ Prostacyclin all contribute to a lower PVR.

The opposite factors cause the PVR to remain high, for example:

  • Lung disease, and inadequate lung inflation
  • –Surfactant deficiency
  • –Retained fetal lung fluid
  • –Inadequate inflation at birth
  • Chronic intrauterine hypoxemia which leads to vascular remodeling
  • Acidosis, sepsis, other stressors which cause pulmonary vasoconstriction
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12
Q

basic transitional events in glucose metabolism

signs of and risk factors for hypoglycemia in the immediate newborn period

A

The fetus receives a continuous intravenous glucose supply in utero, via umbilical circulation, which is abruptly cut off at birth

  • Insulin does not cross placenta, but glucose does (from mother to fetus)
  • Insulin production by the infant should cease quickly as glucose falls
  • The production of insulin, however, is excessive and prolonged in infants of diabetic mothers (IDM), due to islet cell hyperplasia in the fetus in response to chronic hyperglycemia

Glucose is initially maintained by mobilization of hepatic glycogen stores

  • Premature or IUGR babies have no glycogen stores
  • Asphyxia, stress: stores used up quickly

Thereafter, glucose is provided by gluconeogenesis from protein, glycerol (fat) and lactate
-These substrates are also limited in premature and IUGR infants

Risk infants should be screened during first hours of life

  • Intrauterine growth restricted (IUGR)
  • Premature
  • IDM
  • Polycythemia

Signs:

  • Jittery!!! (tremulous)
  • Irritable
  • Lethargic
  • Apnea
  • Seizures

Diagnosis:

  • Blood glucose < 45 mg with symptoms/signs
  • Blood glucose < 35-40 mg with risk factors, but asymptomatic (intervention level a little controversial)
  • Lowest glucose is within 2-4 hours of birth

Treatment:

  • Feed (formula) if baby able and willing to do so
  • IV glucose if baby not able to feed, or if the glucose is not improved after feeding, or if the glucose is very low (< 25-30 mg), or if life-threatening symptoms (apnea, seizures) are present
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13
Q

physiologic signs expected during normal transition and the clinical signs of an abnormal transition

A

Risk Factors for an Abnormal Transition:

  • Impaired fetal growth (IUGR), which implies chronic poor placental function
  • –Poor nutrition and poor O2 delivery during pregnancy
  • –Sets the stage for abnormal transition, delayed fall in PVR, poor glucose and temperature homeostasis
  • Maternal diabetes, hypertension, premature rupture of membranes, bleeding, or chorioamnionitis
  • Delayed or no prenatal care
  • Preterm (< 37 weeks gestation) → could be cocaine or methamphetamine related
  • No labor → elective C/S without labor

Recognizing Abnormal Transition (Term Infants):

  • Prolonged or excessive respiratory distress and/or need for supplemental O2
  • Failure to maintain normal temperature (worry about infection or CNS issues), glucose
  • Lethargy, not interested in feeding, persistent hypotonia: babies should always be good feeders (unless premature)
  • Apnea events with bradycardia or cyanosis
  • Pallor with poor skin perfusion and delayed capillary filling time (shock, acidosis), or excessive ruddiness (plethora, polycythemia)
  • Tremors, jitteriness
  • Choking spells, cyanotic episodes, “spells” of any kind
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14
Q

importance of adequate lung inflation, surfactant production, and lung liquid absorption to the physiology of transition to extrauterine life

A

Establishes lung volume, FRC (functional residual capacity)
-Sets the stage for easy tidal breathing

Increased alveolar oxygen:

  • Decreases pulmonary vascular resistance and increases pulmonary blood flow
  • Increases arterial pO2 leading to constriction of ductus arteriosus
  • Increases pulmonary blood flow leading to increased left atrial volume closure of foramen ovale flap

Take home:
-Lung inflation is the key to cardiovascular transition as well.

Within the amniotic sac, the fetal lungs are filled with fluid, and the pulmonary epithelium secretes fluid by active Cl- secretion, while Na+ absorption is limited.

  • The fluid exits via the trachea into the amniotic space.
  • This is the basis for testing amniotic fluid for lung maturity.
  • At birth the fluid needs to be cleared quickly so that ventilation with air can be established.
  • –Corticosteroids cause an ↑ Amiloride-Sensitive Selective Epithelial Na+ channels, ENac, during late gestation.
  • –Causing fluid absorption.
  • –↑ Intrathoracic pressure during labor results in more egress of fluid from the trachea; less emptying occurs during C-section without labor.
  • –Hydrostatic forces move the fluid distally through the airways and into the interstitium with inspiration, no return to the air space during exhalation. FRC builds during inspiration.

Failure of fluid absorption = retained fetal lung fluid also called Transient Tachypnea of the Newborn, TTN.

  • If excessive fluid / delayed absorption by the vasculature and lymph from the interstitium, oxygen is required.
  • Observed in: C-section without labor, maternal β-blocker therapy, ineffective inspirations.
  • Generally seen in term and late preterm infants, mild respiratory distress, short course, well-inflated but wet-looking lungs on CXR.
  • Can progress to severe respiratory failure.
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15
Q

unique circulation of the fetus and how it differs from the newborn (adult) circulation

A

The fetal circulation

  • The placenta is the organ of gas exchange, with the best-oxygenated blood coming to the fetus through the umbilical vein, shunting through the ductus venosus bypassing the liver to the right atrium (RA)
  • The placenta has very low vascular resistance, creating a very low systemic vascular resistance as blood returns to it from the fetal aorta through the umbilical arteries
  • Conversely the pulmonary vascular resistance is very high in the fetus, and the pulmonary blood flow is very low due to active pulmonary vasoconstriction
  • Local hypoxemia, acidosis, fluid-filled lungs, and possibly leukotrienes maintain the vasoconstriction
  • Blood is shunted from the right atrium (RA) to the left atrium (LA) through the foramen ovale, and from the pulmonary artery (PA, high resistance) to the aorta (Ao, low resistance) through the ductus arteriosus (DA)
  • –In utero, < 10% of combined ventricular output goes to the lungs
  • –In utero, the right ventricle (RV) is the systemic (main) ventricle as very little blood flow returns from the lungs to the left atrium and left ventricle (LA, LV) for exit out the Ao
  • In utero, the pulmonary and systemic circulations are connected but parallel

Following birth

  • the lungs expand with air, the placenta is removed from the circuit (the cord is cut), and the circulation changes dramatically
  • With lung expansion, pulmonary vascular resistance begins to fall
  • –Pulmonary blood flow increases, PaO2 increases
  • –Venous return to the LA increases
  • With cord clamping and cold stress/vasoconstriction, systemic vascular resistance increases
  • Pressures in the LA become greater than in the RA, and the foramen ovale flap closes
  • With increased PaO2, and ↓ in local prostaglandin and NO production, the DA constricts
  • The circulations are now in series (as in the adult): blood enters RA, goes to RV, through PA to lungs, returns to LA, through LV and out to Aorta; 50% of combined ventricular output now goes to lungs

The following changes are reversible.

  • The DA constricts but is not anatomically closed for days to weeks
  • The foramen ovale flap can reopen to allow blood to flow from RA to LA if RA pressure > LA
  • Normal transitional circulation is a balance between pulmonary vascular resistance and systemic vascular resistance: blood flows from higher to lower resistance across these reversible fetal channels
  • In the case of increased pulmonary vascular resistance, often accompanied by or aggravated by decreased systemic vascular resistance (hypotension), R to L shunting at foramen ovale + DA can recur or continue: known as Persistent Pulmonary Hypertension of the Newborn (PPHN)
  • The placenta, however, cannot be replaced - that move was permanent.
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16
Q

concept of persistent pulmonary hypertension in the newborn

A

3 main categories of PPHN:

Abnormally constricted pulmonary vessels

  • as with parenchymal lung disease, poor lung inflation following birth
  • reversible with lung inflation, correction of acidosis

Abnormal pulmonary vascular musculature remodeled

  • as with antenatal closure of DA, maternal NSAID use, chronic intrauterine hypoxemia
  • not easily reversible

Hypoplastic pulmonary vasculature tree

  • as with pulmonary hypoplasia from any cause – decreased vascular cross-sectional area
  • not completely reversible
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17
Q

5 theoretical models for gender development with rationale and criticisms

A

Social Cognitive Development Theory:

  • Children develop a sense of gender from what they observe and experience around them
  • The interaction between the child’s thoughts (I am a girl) and behaviors (acting like a girl) lead to gender constancy.
  • Cognitive consistency is self-satisfying, so children behave in ways that match their self-conception
  • Gender identity becomes a basic organizer for the child’s gender learning

Social Cognitive Theory:

  • Social cognitive theory posits that, through cognitive processing of direct and vicarious experiences, children come to:
  • –categorize themselves as girls or boys
  • –gain substantial knowledge of gender attributes and roles
  • –extract rules as to what types of behavior are considered appropriate for their gender
  • Through social interactions, children and adults develop internal self-conceptualizations about their gender that can have a huge impact on:
  • –behavior
  • –perspective
  • –aspirations
  • –self-satisfaction
  • –self-esteem
  • –mental well-being

Freud
-Psychoanalytic theory
—Intrapsychic processes drive gender identification and development.
—Identify first with opposite gender, develop erotic feelings for them (Oedipus/Elektra complex)
—get anxious due to fears of retaliation from other parent so identify with that parent instead to resolve the dilemma.
—Criticism
===No evidence. Kids tend to connect with nurturing, not threatening parents.

Kohlberg

  • Cognitive Developmental theory
  • –Children develop a sense of gender from what they observe and experience around them.
  • –The interaction between the child’s thoughts (I am a girl) and behaviors (I am acting like a girl) lead to gender constancy.
  • –Gender identification becomes the basic organizing principle to figure out what you’re supposed to do.
  • Criticism
  • –Little evidence.
  • –Gender-linked behavior is seen before gender constancy or any recognizable cognitive understanding of gender has set in.

Bem & Markus

  • Martin & Halverson
  • Gender Schema Theory
  • –Labeling oneself as male or female forms the basis for a cognitive schema for gender. —The schema expands as you get older.
  • –Children act according to their gender schema motivated by wanting to match those of their own sex.
  • Criticism
  • –No evidence that a complex or extensive “schema” of gender leads to a stronger gender ID.
  • –No info about how a schema translates into behavior.

Archer, Buss, Simpson & Kenwick
-Evolutionary Influences
—Gender differences are determined by what is biologically and evolutionarily successful including passing along their genes.
—Criticism
===Doesn’t really address developmental changes we see and doesn’t fit current behaviors.
-Hormonal influences
—Distinction in neuronal development drives gender differences.
—Example: lateralization of the brain is distinct between male and females
—Criticism
===Lateralization is minor and getting less pronounced with time, suggesting that differences are social and related to environment.
-Behavioral Genetics
—Some gender differences derive from genetics, others from environment.
—Criticism
===Hard to separate the two experimentally.
-Sociology
—Gender is mainly derived from culture → gender differences are decreasing as society becomes more permissive.
—Criticism
===People are not mere victims of their socio-cultural environment.

Bandura & Bussey

  • Social-Cognitive Theory
  • Mix of evolutionary forces, social and environmental interactions contribute to gender.
  • –Everything influences everything.
  • Through cognitive processing of direct and vicarious experiences, children come to categorize themselves as girls or boys, gain substantial knowledge of gender attributes and roles, and extract rules as to what types of behavior are considered appropriate for their gender.
  • Criticism
  • –Can’t really create a hypothesis-driven experiment to test this given that it tries to combine too many things.
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18
Q

differentiate between terms gender identity, gender stability, gender consistency, and gender constancy

A

Gender identity:
-label self and others as boy or girl, but believe it is possible to change/switch gender

Gender stability:
-recognize gender is stable over time but not over situations (boys can become girls if they wear a dress)

Gender consistency:
-gender is invariant despite changes in appearance, dress, or activity

Gender constancy:

  • realize gender is consistent over time and situations
  • belief that gender is fixed and irreversible
  • begin to identify with people of their own gender and behave in gender appropriate ways
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19
Q

differentiate between sexual behaviors in children that are typically considered normal and those that are typically considered abnormal

A

Normal and common:

  • touching/masturbating genitals in public/private
  • viewing/touching peer or new sibling genitals
  • showing genitals to peers
  • standing/sitting too close
  • try to view peer/adult nudity

Less common and normal:

  • rubbing body against others
  • trying to insert tongue in mouth while kissing
  • touching peer/adult genitals
  • crude mimic of movements assoc w/ sexual acts
  • sexual behaviors that are occasionally, but persistently, disruptive to to others

Uncommon in normal children:

  • asking peer/adult to engage in specific sexual acts
  • inserting objects into genitals
  • explicit imitation of intercourse
  • touching animal genitals
  • sexual behaviors that are frequently disruptive to others

rarely normal:

  • any sexual behaviors involving children who are 4 or more years apart
  • a variety of sexual behaviors displayed on a daily basis
  • sexual behavior that results in emotional distress or physical pain
  • sexual behaviors associated with other physically aggressive behavior
  • sexual behaviors that involve coercion
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20
Q

relative incidence of child abuse as a pediatric diagnosis

A

child abuse and neglect:
25/1,000

relatively common childhood disease

sexual abuse:
-incidence has gone down drastically since 1992, but has had a slight increase recently

neglect substantiation rates:
-declined

number of foster care children:
-33% decline

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21
Q

diagnose physical and sexual abuse

A

Abuse:

  • physical
  • sexual
  • emotional
  • Munchausen Syndrome by proxy

Neglect:

  • physical
  • emotional (non-organic failure to thrive)
  • medical care

common historical findings in child abuse cases:

  • discrepant history (does not fit w/ physical findings)
  • –caretaker may not know; imperative not to accuse the caretaker
  • delay in seeking care (abuser hopes injury is not serious vs a protective parent vs healthcare professional)
  • stressed caretaker
  • behavior by the child that triggers the abuse
  • –crying or toilet accidents
  • –never tell a caretaker “just let the baby cry” unit you ask about how they feel when a baby cries uncontrollably
  • prior history of abuse in the abuser
  • unrealistic expectations of the child
  • social isolation of caretaker
  • pattern of increased severity of injury if first injuries unrecognized
  • use of multiple hospitals or caretakers
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22
Q

interventions proven to prevent the physical and sexual abuse of children

A

approaches to sexual abuse prevention:

  • resistance building
  • –“good touch/bad touch” safety training
  • –some evidence this works
  • external inhibitors
  • –adding parent volunteers to boy scout trips, for ex.

prevention of sexual abuse:

  • 40% reduction of sexual abuse in last decade and we have no clue why
  • parent education
  • –parents as first teachers, parenting classes
  • public health nurse home visitation
  • –PHN visitation during first 2 trimesters of pregnancy and first 2 years of life can reduce physical abuse by 87% over lifespan of child
  • –should be a basic health benefit, not a “program”
  • Strong communities for Children
  • –someone will notice and do the right thing
  • SEEK
  • –primary care health based screening and intervention with social worker support to create a “safe environment for every kid”
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23
Q

studies that suggest a biologic basis to abusive and neglectful behavior and the child’s ability to “survive” it

A

Kessler and Norepinepherine
-FosB knockouts treatable

Caspi and the Dunedin Boys
-MAO Activity predicts outcomes

Finkelhor and the declining incidence of abuse and neglect
-Is the increased use of psychopharmacologic agents responsible?

Pedophiles have reduced volume of the amygdala (area of brain critical for sexual development) compared to non-pedophiles

Felitti “Adverse Childhood Experience” studies.

genetics and epigenetics both play a role

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24
Q

summarize adolescent morbidity statistics

A

mortality:

  • preventable deaths 72.3%
  • –COD: accidents > homicide > suicide
  • –critical to talk to your pts

morbidity:

  • 831,000 pregnancies
  • 4 million STDs
  • 1/3 high school males carry weapon
  • 6% physical fight
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25
Q

define, compare, and contrast the 3 developmental stages of adolescence

A
Early adolescence: 12-14yo
-independence
===decreased interest in parental activities
===wide mood swings
-body image
===preocupation with self and pubertal changes
===uncertainty about appearance
-peers
===Intense friendship with same-sex friends
-identity
===begins abstract reasoning
===increase fantasy world
===idealistic vocational goals
===increased need for privacy
===lack of privacy
Middle adolescence: 15-17yo
-independence
===peak of parental conflicts
-body image
===acceptance of body
===concern over making body more attractive
-peers
===peak peer involvement
===conformity with peers
===increased sexual activity and experimentation
-identity
===increase scope of feelings
===increase intellectual ability
===feeling of omnipotence
===risk taking behavior
Late adolescence: 18-21yo
-independence
===re-acceptance of parental advice and values
===adult-adult interaction
-body image
===comfort with pubertal changes
-peers
===peers less important
===more time with intimate relationships 
-identity
===practical, realistic
===refinements of moral, religious, and sexual desires
===ability to compromise and set limits
26
Q

various psychosocial tasks of adolescents

A

Cognitive development:

  • ability to think as an adult
  • occurs in middle adolescence
  • formal operational thought
  • starts at 12yo
  • concrete to abstract
  • moral choices
  • “Ideal partner”
  • serial monogamy
  • physical and cognitive NOT simultaneous
Psychosocial tasks:
-independence
---Early: 
===decreased interest in parental activities
===wide mood swings
---Middle:
===peak of parental conflicts
---Late:
===re-acceptance of parental advice and values
===adult-adult interaction

-body image
—Early:
===preocupation with self and pubertal changes
===uncertainty about appearance
—Middle:
===acceptance of body
===concern over making body more attractive
—Late:
===comfort with pubertal changes

-peers
—Early
===Intense friendship with same-sex friends
—Middle:
===peak peer involvement
===conformity with peers
===increased sexual activity and experimentation
—Late:
===peers less important
===more time with intimate relationships

-identity
—Early:
===begins abstract reasoning
===increase fantasy world
===idealistic vocational goals
===increased need for privacy
===lack of privacy
—Middle:
===increase scope of feelings
===increase intellectual ability
===feeling of omnipotence
===risk taking behavior
—Late:
===practical, realistic
===refinements of moral, religious, and sexual desires
===ability to compromise and set limits

Tasks:

Early:

  • pubertal growth and development
  • –reassurance
  • concrete thinking of childhood
  • begins separation from parents
  • –encourage postponing coitus

Middle:

  • starts making moral choices
  • imagines consequences but unable to assess them
  • –safe sex counseling
  • –contraception
  • increase peer pressure
  • –conflicts with parents at peak

Late:

  • formal operational thought
  • –encourage
  • personal value governs choices
  • –empower
  • Acceptance/development of parental values
  • –ability to negotiate system
27
Q

compare and contrast pubertal development in boys and girls

A

Puberty:

  • thelarche is first sign in females (breast)
  • testicular size is first sign in male
  • peak height velocity is later in M
  • peak height velocity precedes menarche in F
  • menarche occurs 2 yrs after onset of puberty
Male sequence: (gonad, puberty, height)
G2 --> G3
P2 --> G4
P3
Peak height velocity
P4
G5 --> P5
Female sequence: (gonad, breast, height)
B2 --> P2
Peak  height  velocity
B3 --> P3
B4 --> P4
Menarche
P5 --> B5
28
Q

components of Adolescent Interview using the HEEADSSS mneumonic

A
HEEADSSS:
Home
Education and Employment
Eating
Activity
Drugs
Suicide and Depression
Sexuality 
Safety
29
Q

define and describe aging, life expectancy, and life span

A

Aging: natural, progressive decline in body function

  • effects are cumulative, irreversible
  • accelerates w/ advancing years
  • rate of aging seems to vary from normal for some individuals

Mechanisms of aging:

  • inherited flaws in genomic stability
  • inefficiencies of oxidative phosphorylation and production of ROS

mTOR: the Rosetta Stone of Aging
-inhibiting mTOR mimics caloric restriction (and preserves aging)

Pathways that determine aging:

  • diminish activity and life is extended
  • growth pathways IGF-1
  • nutrition sensing mTOR pathway
  • energy metabolism-mitochondrial electron transport

Life expectancy:
Significant increase during this century. In 1890 (U.S.) life expectancy averaged 47 years.
In 2013 it reached 80 years (men 77 yrs; women 82yrs)
Women outlive men by 7-10 years - this is true worldwide. Men acquire significantly more infectious disease and cancer than women.
-if major diseases like heart disease and cancer were cured, we might reach 85-90 yrs life expectancy, but not much more

Life span:
maximal life expectancy
The life spans of different species are quite distinct and fixed.
For humans, life span is about 110 years, although very few individuals ever reach this advanced age. Humans have the longest life span among mammals. For many animals, there is a correlation between the body surface to body mass ratio (an indicator of metabolic rate) and life span. Faster this rate, the shorter the life span.

30
Q

demographic and economic effects of the projected increase in the aging population in the US

A

increased aging population

31
Q

effects of aging on the body’s organs and tissues, and on the susceptibility to important diseases

A

Normal aging:

  • hair:
  • –thinning, graying, hair loss
  • skin:
  • –loss of elasticity, thinning, emergence of “age spots”
  • Eye:
  • –farsightedness, cataracts
  • Hearing:
  • –loss
  • Skeleton:
  • –age related osteoporosis, degenerative arthritis
  • brain:
  • –atrophy; 10% loss of vol between age 35 and 60; mainly due to loss of myelin; some loss of subcortical nuclei in the grey matter; often mild problems w/ cognition and memory
  • Lung:
  • –loss of elastic tissue; accumulation of anthracotic pigment (esp for city dwellers), often mild emphysematous changes
  • Hematopoietic system:
  • –atrophy of spleen, thymus, and bone marrow
  • Soft tissue:
  • –increase in body fat
  • Kidneys:
  • –always some loss of nephrons
  • Heart and liver:
  • –accumulation of lipofuscin, the “wear and tear” pigment; a product of peroxidation of unsaturated fatty acids
  • Arteries and veins:
  • –always some generalized atherosclerosis, varicosities are common

Diseases associated with aging:

  • Cancer
  • –most cancer deaths occur ~70yo
  • –in general, carcinoma (epithelial cancer) is disease of advancing age
  • –accumulation of somatic mutations in genes of a stem cell that regulate cell function
  • Generalized atherosclerosis:
  • –hardening/narrowing of aries 2/2 intimal deposits of lipid and cholesterol-rich plaque
  • –unable to supply adequate oxygenated blood to organs
  • –increases risk of HTN, sudden occlusion from thrombosis, MI, stroke, organ failure
  • Cerebrovascular accidents (Strokes):
  • –more common w/ increasing age, as is systemic HTN
  • Non-insulin dependent diabetes mellitus (T2)
  • –DM reduces life expectancy by 10 yrs (accelerates aging)
  • –accelerated atherosclerosis
  • –diabetic nephropathy (thick BM); nodular glomerulosclerosis; renal insufficiency, renal failure
  • –higher risk of infection (pyelonephritis)
  • –poor wound healing
  • –high blood sugar –> HTN and high cholesterol
  • increased risk of thromboembolism
  • –blood clots form in veins (thrombosis), then break off and embolize to distant sites
  • Alzheimer’s and Parkinson’s disease:
  • –Parkinson’s- extensive loss of dopamine neurons
  • –risk of aspiration, falls, dementia in some pts (Lewy body variant)
32
Q
characterize, compare, and contrast 2 major theories of aging, including roles played by:
familial aspects
somatic cell death programming
telomeres
longevity genes and Sir2
lipofuscin 
metabolic rate and caloric restriction
mitochondria and mtDNA mutations
helicase
A

Theory #1: The clock theory

  • aging process and death are programmed in the same way that early development is programmed
  • aging is controlled by aging genes
  • somatic cells are “programmed” to die after a set number of cell divisions
  • human fetal fibroblasts generally become senescent after 80 doublings
  • fibroblasts from old adults may senesce after 10-20 doublings
  • –somatic senesce may be controlled by shortening tips of telomeres during division
  • –telomeres are long repeats of TTAGGG; shortens about 60bp/yr in aging
  • –telomeres help stabilize chromosome ends and are needed for faithful chromosome segregation

Theory #2: The rust theory

  • aging results from the accumulation over time of oxidative damage to cells and tissues
  • aged individuals have elevated levels of lipofuscin, cross-linked collagen, and oxidized DNA and protein
  • by 80yo, oxidized protein may be 20-30% of total cellular protein
  • lowering metabolic rate of many species by restricting calories will increase longevity 30-50%
  • –level of oxidative damage is largely determined by the metabolic rate
  • –higher rate = more damage
  • with aging, there’s a well-known increase in levels of somatic mutations in mitochondrial DNA
  • –mtDNA sustains high rate of oxidative injury; location and cannot be repaired we’ll
  • –accumulation of mutations in mtDNA in somatic tissue may cause well-documented decline in oxidative phosphorylation that occurs as we age
33
Q

features and underlying causes of progeria and Werner syndrome

A

Progeria:

  • supported by Theory #1 (aging is controlled by a clock)
  • human genetic disease that causes premature aging
  • life span is only ~10yrs
  • death usually from cardiac or cerebrovascular disease
  • mutation in Lamin A gene (intermediate filament present in the nucleus; tethers the chromosome to the nuclear envelope)
  • genetic instability

Werner syndrome:

  • affected pts show signs of aging in early 20s
  • cataracts, aging changes in skin/hair
  • early onset cancer and heart disease
  • death by 50yo
  • mutation in DNA helicase
  • –some defect in repair of DNA damage
34
Q

impact of aging demographic imperative on the practice of medicine in the future

A

baby boomers have reached 65yo, so proportion of population has increased significantly

  • “old” old (>85yo) is the fastest growing population
  • the population has turned from a triangle distribution to a rectangle
  • –and the pts at the top of the rectangle are needy; resource-utilizers; lots of money with questionable benefit

> 65yo pts are using a lot of medications, hospital beds, and nursing home beds

we’ve mostly prevented deaths from 0-65yo; how long you live past 65yo has a lot to do with genetics

35
Q

concept of compression of morbidity and mortality

A

if you have a disease or a trauma:

  • first ~20yrs it’s subclinical
  • decline in functional abilities
  • dysfunction
  • disabled
  • we would like to extend subclinical phase to stay higher up on functionality curve

physiologic changes with aging:

  • max out at age 30
  • variability of the elderly
  • aging vs disease vs disuse
  • concept of homeostasis –> “homeostenosis”
  • physiologic aging results in diminished reserve
36
Q

how changes in body composition impact disease and function in older individuals

A

body composition:

effects of time –> change in body composition

sarcopenia: (flesh loss)
- no decline with age is as dramatic or potentially more significant than the decline in lean body mass
- age related muscle atrophy and functional loss are major contributors to morbidity and mortality in the elderly
- by 75yo, ~1/3 are sarcopenic, low muscle mass, and increased weight
- functional significance:
- –decreased muscle mass (and quality) –> decreased strength –> decreased function
- worse if you’re obese, but almost just as bad if you’ve stayed the same weight but lost muscle mass

fat distribution:

Metabolic syndrome: 
-obesity is a key factor in:
---insulin resistance/hyperinsulinemia
---glucose intolerance and T2DM
---HTN
---Dyslipidemia
---Abnormal fibrinolysis
===ASDVD from any/all of the above

Loss of physiologic reserve is one thing, but the real key is ACTIVE life expectancy

  • primary aging is unavoidable
  • –loss of physiologic reserve
  • –decline in physical functional abilities
  • secondary aging contains modifiable risk factors
  • training reduces functional age and increases reserve capacity

enhancing function and QL:

  • physical activity and health promotion
  • –physical inactivity 2nd to tobacco as cause of morbidity and mortality
  • regular physical activity (even for very old/frail)
  • –increase function/decrease falls/decrease liability
  • –disease prevention/tx–> DM, CVD, HTN, etc
  • –psychological health –> sleep, cognition
  • prescription for exercise:
  • –strength, balance, aerobic, flexibility
  • –intensity, frequency, duration

function vs physiology:

  • hospitalization in someone at risk at baseline-
  • –“The Precipice effect”
  • –they start closer to the edge of falling-off w/ function, and it takes a lot more time to recover, and may not get back to 100%
37
Q

concept of physiological reserve and its importance in older individuals

A

loss of physiologic reserve:

  • renal/volume regulation
  • –decreased GFR
  • –decreased ADH/renal response to hypovolemia
  • –decreased Na exertion response to hypervolemia
  • –decreased excretion of drugs
  • –decreased ability to compensate for volume depletion and volume overload states
  • –serum Cr alone does NOT provide adequate information regarding renal function
  • –modified formulas for estimating GFR in older adults (MDRD, CG)
  • heart
  • –increase LV and arterial stiffness
  • –decreased beta-adrenergic receptor responsiveness
  • –decreased maximum HR and CO
  • –increased systolic and pulse P
  • –diastolic stiffness (increased reliance on atrial kick)
  • –increased risk postural hypotension
  • pulmonary
  • –decreased elasticity (compliance)
  • –increased residual capacity
  • –decreased vital capacity
  • –decreased closing pressure
  • –increased atelectasis
  • energy/work capacity (VO2 max)
  • –VO2 max drops more quickly with age and lack of activity
  • –Relative Energy cost of walking increases with age; ~93% at 80yo (7% left of functional reserve)
  • –when you lose maximal physiological capacity, you lose functional reserve (the ability to compensate in the face of stress)
  • body composition and insulin/glucose
  • brain
  • bone
  • sensory
38
Q

how illnesses may present in older vs younger adults

A

often multiple causes for a problem

  • differences in clinical presentation
  • ex. fall
  • –vision, meds, arthritis, etc
  • –not often just one cause
  • weight loss
  • –psychosocial, meds, oral/GI changes, etc
  • –usually NOT cancer
  • addressing modifiable factors can help
  • presentation of acute illness is often asymptomatic
  • –weakness/dizziness/syncope
  • –falls
  • –confusion
  • –acute MI w/o chest pain- #1 symptom is dyspnea
  • –infection/sepsis often w/o fever or leukocytosis
  • may be substantial lag between dx/tx and improvement

febrile illness/infection:

  • fever may be absent in 20-30% elderly w/ serious infection
  • fever may be absent in 30-50% frail elderly w/ serious infection
  • adjusting diagnostic criteria for elderly
  • -single temp >100 or repeated temp >99, or rise >2 over baseline
  • increased sensitivity to over 80%; maintains specificity 90%
39
Q

key components of comprehensive geriatric assessment

A

“how old would you be if you didn’t know how old you were?”

What we ask:
-chronologcial age
What we should be asking:
-pshysiological age
what we need to know:
-functional status

Functional assessment:

  • objective measurement allows appreciation of deterioration/improvement over time
  • change in functional status is an important presenting symptom
  • function helps prioritize individual problems
  • function is important in deciding treatment efficacy
  • knowing baseline function in managing acute illness
  • ADLs (activities of daily life) and IADLs (instrumental)
  • –first need: bathing
  • –dressing
  • –transferring (bed to chair)
  • –toileting
  • –grooming
  • –feeding
  • mobility/falls
  • continence
  • –telephone, shopping, food prep, housekeeping, laundry, utilizing transportation, ability to medicate/handle finances

physical assessment:

  • medications (major cause of illness, hospitalization, and mortality)
  • –high risk for ADRs (polypharmacy, comorbid conditions, impaired renal function not evident in serum Cr)
  • –compliance is often problematic
  • nutrition
  • alcohol
  • vision and hearing
  • “get up and go” test- stand from chair w/o arms, walk 10ft, turn around, come back”

mental assessment:

  • depression
  • –geriatric depression scale
  • –2 question screen:
  • –past 2 weeks felt down, depressed, or helpless?
  • –felt little interest or pleasure in doing things?
  • cognition
  • –Mini mental status exam
  • –“Mini-cog” w/ 3 item recall, and clock test
  • competence

social assessment:

  • support systems
  • advanced directives
40
Q

differences in hospital care approaches to older pts

A

Differences in hospital care:

  • avoiding iatrogenic immobility
  • –keep them moving!

Iatrogenic issues: immobility
-consequences:
—orthostatic intolerance
—loss of muscle mass within 24 hrs supine position
—after adjust for illness severity and comorbidity,
===low mobility in hospital –> increase functional decline and new nursing home placement
-approaches:
—discontinue bladder catheters, IV lines, encourage activity
—order PT early and confirm pt participation
—ambulate in hallway (only 27% did so in one study)
—“road test” your pt prior to discharge

EBM in elderly pts: caveats and cautions

  • many elderly pts don’t make it into clinical trials, so you don’t have EBM to support medical decisions
  • studies rarely include frail elderly, muliti-comorbid disease pts
  • risks (drug-drug, drug-disease interactions) may be increased
  • short and long term goals?
  • pt preferences?

screen all F pts >65yo for osteoporosis

bottom line

  • focus on meds and cut meds
  • maintenance/restoration of function and independence is primary
41
Q

associate place of death with key outcomes for dying pt and their survivors

A

many pts prefer avoiding intensive EOL care

  • most pts die as a hospital inpatient, though
  • pts who die in hospital have lower QOL report and higher levels of physical and emotional distress
  • caregivers have higher risk of PTSD and prolonged grief disorder if aggressive measures were taken prior to death
42
Q

ramifications of ICU care at the end-of-life (EOL)

A

worse QOL assoc w/ receiving life-prolonging procedures

43
Q

differentiate between hospice and palliative care

A

Palliative care:

  • fills in the GAPS
  • –Goals of care
  • –Advance Care planning
  • –Psycho-social spiritual support
  • –Symptom control
  • specialized medical care for people with serious illness
  • team
  • improve QOL
  • INDEPENDENT of prognosis
  • the best possible day now
  • –provide the opportunity to discuss what matters most
  • –match that to plan of care
  • Primary palliative care:
  • –basic skill sets that every health care provider should have
  • Speciality:
  • –Advanced skill sets for the more complex pt situations

Hospice:

  • specialized form of palliative care focused at EOL care
  • both philosophy and delivery system of care
  • DEPENDENT on prognosis
  • – <=6mo
  • –not trying to fix what can’t be fixed

Palliative care increases QOL in seriously ill
Hospice increases QOL at end-of-life

44
Q

physiologic changes that accompany the dying process

A

49% recognized dying <24 hours prior to death
21% recognized dying <72 hours prior to death

active dying process usually takes hours to days
-sudden death is not common

physiologic changes:

  • not what we see in everyday pts
  • certain changes are normal during the process
  • –mouth and eyes remain open
  • –others possibly incl temporal wasting, jaundice, nasal flaring, hyperpigmentation
  • bedbound
  • changes in skin color and temperature
  • loss of bowel sounds
  • cardiovascular
  • –skin mottling (purple lace pattern from vasoconstriction)
  • –peripheral cooling, cyanosis
  • –decreased urine output
  • –hypotension, tachycardia–> bradycardia
  • –fluids will not help

-neurologic
—decreased level of consciousness
—dysphagia
—loss of sphincter control
—terminal delirium
—near-death awareness
—termina delirium
===not reversible
===may be agitated delirium (restlessness, moaning, groaning)
===management- support family; calm and familiar environment; sit w/ pt; reassurance
===pharmacologic Mx: neuroleptics? Haloperidol, chlorpromazine

  • respiratory
  • –really anything on a spectrum of abnormal breathing
  • –families tend to notice this the most
  • altered breathing patterns: looks and sounds different
  • –build up of saliva/mucous (gurgle, rattle)
  • –pharyngeal muscles relax (snoring)
  • educate family
  • positioning
  • discontinue IV fluids
  • suctioning does not provide comfort
  • do not need to add oxygen
  • Anticholinergics for Secretions?
  • –atropine drops SL; Scopolamine; Glycopyrrolate
  • Opioids for dyspnea: NO evidence that they hasten death

avoid signs of pain

  • facial grimacing, moaning, restlessness
  • warrants trial opioids
  • many are undertreated
  • changes that tend to be most apparent to family:
  • –breathing
  • –altered level of consciousness
  • –decreased appetite/fluid intake

-decreased oral intake
—anorexia
—food may be nauseating
—increased risk of aspiration
—not utilizing nutrients
—may be protective
===ketosis increases endorphin release
—pt is NOT starving to death (family is worried about this)
===death is from underlying disease process
===not eating/drinking is a normal part of this process
—no evidence that artificial nutrition/hydration improves QOL or prolongs life
===artificial fluids may be harmful
===fluid overload, edema, dyspnea
—educate family
—help family find other ways to show they care
—keep mouth moist and clean

45
Q

communicating with a dying person

A

families want to communicate the most when pt is dying

  • assume pt can hear everything
  • talk as if they were fully conscious
  • encourage family to say things they need to say
  • some pts may be waiting for “permission” to die
  • educate on what to expect (see, feel, hear)
  • we can’t control when pt will die
  • –focus on comfort to support the pt
  • self care
  • support
46
Q

physician’s role after a pt dies

A

Evaluate for signs that death has occurred:

  • neurologic
  • –not responsive
  • –absent CN reflexes
  • pulmonary
  • –absent spontaneous respirations
  • –no breath sounds
  • cardiac
  • –absent pulse
  • –no heart beat

other signs:

  • grey-ashen skin, cold
  • eyes and mouth may remain open
  • body fluids may trickle/seep
  • stiffening of body

death pronouncement:

  • avoid telling family over phone
  • if family is present: allow them to stay; be respectful

after death:

  • care focuses on loved ones
  • offer chaplain support
  • okay to touch and talk to body
  • let family have time w/ body
  • family may have post-death rituals
  • your role is not to make it all better
  • we grieve
  • words are NOT what is most important now
  • MOST IMPORTANT to let family know you are there for them
  • be genuine
  • LISTEN to them (share memories; don’t talk about yourself)
  • NOT a time to go over medical details
  • your own self care; okay to show emotion; debrief
47
Q

use of death, dying, died, dead words in end of life discussions

A

best to use direct “D” words-

  • try to avoid euphemisms
  • –miscommunication, misleading, confusing
  • if you must use a euphemism, tie it together with a direct D word
48
Q

categories of urinary incontinence

A

UI:
the complaint of any involuntary leakage of urine

Stress incontinence:
involuntary leakage on effort or exertion, or on sneezing or coughing
-Type 1:
—in the absence of urethral hyper mobility
-Type 2:
—due to urethral hyper mobility
===Most common cause of stress incontinence
===lack of backstop
===Results from poor urethral support
===Many women with urethral hypermobility + well-functioning sphincter are not incontinent
-Type 3:
—due to intrinsic sphincter deficiency
===Usually results from deterioration of urethral musculature and/or neurologic injury
===Urine loss may occur from minimal activity (e.g., coughing)
(external urethral sphincter can’t stay closed)
-graph

Urge incontinence:
involuntary leakage accompanied by or immediately preceded by urgency
-overactive bladder (involuntary bladder contraction)
—more than one symptom MUST be present
===urgency, frequency, nocturnal enuresis
-subtypes
—-neurogenic
—myogenic
—idiopathic
-detrusor overactivity
—graph shows a cough will cause abnormal increase in detrusor activity

Mixed incontinence:
involuntary leakage associated with urgency and also w/ exertion, effort, sneezing, or coughing

The intrinsic sphincter, comprised of bladder neck muscle fibers and the mid-urethral complex, is responsible for continence

Mech of urination:

  • Storage phase
  • –NE and Serotonin released
  • –signals detrusor to relax and urethra to contract
  • Emptying phase
  • –ACh released
  • –Signals detrusor to contract
49
Q

MOA for pharmacologic therapy for overactive bladder

A

Anti-muscarinics
-Non selective
-Selective
-MAINSTAY of medical tx for OAB
—Compete w/ ACh on the muscarinic receptors (M1-5) in the bladder
===80% M2 and 20% M3
—Also affect M receptors in brain, salivary glands, eyes, heart, and bowel
-ACh
—main NT at nerve endings on detrusor muscle
—acts on M3 receptors for bladder function
===bladder constriction
===bowel motility, saliva and tear secretion, and visual accommodation
===blockage of M3 causes DRY MOUTH, constipation, blurred vision, and drowsiness

Antispasmodics:

  • Oxybutynin
  • –SM relaxant facilitates bladder storage
  • –side effects: dry mouth; constipation
  • –contraindicated in pts w/ glaucoma
  • Tolterodine
  • –Muscarinic receptor antagonist
  • Trospium
  • –Quaternary ammonium non-receptor selective antimuscarinic

Tricyclic antidepressants
SSRI’s/ SNRI’s
-both increase urethral tone

Alpha1 adrenergic agonists (to tighten urethral sphincter)

Beta agonists/antagonists
-agonist allows bladder to expand more; constrict urethra, but lets it fill more

Estrogen
-urethra is somewhat open, but estrogen brings more water into lumen of urethra and keeps it more closed
-more mechanical pressure keeping it closed
-urethral pressure is greater than bladder pressure
===don’t leak

Botulinum toxin
-paralyzes bladder muscle

50
Q

management techniques such as Kegel contractions in the treatment of urinary incontinence

A

Kegel exercise:

  • identify the muscle surrounding the anus
  • squeeze this muscle without contracting the buttocks or the abdominal muscles
  • benefits the micturition cycle
  • –kegeling while bladder is contracting causing the urgency sensation can help decrease detrusor tone and decrease urgency

Sympathetics are storing
Parasympathetics are emptying

51
Q

how urodynamic testing is performed and interpreted

A

Urodynamic studies:

Cystometry

  • detects bladder pressures as bladder fills
  • tell me when you think your bladder feels full
  • determine detrusor pressure with fluid levels and coughing

Cough Stress Test
-block urethra with thumb

Multichannel Urodynamics:

  • measures physiologic functions of lower urinary tract
  • pressure catheter in bladder and vagina or rectum
  • use bladder and abdominal pressure to determine detrusor pressure (high= overactive bladder)
  • Pdet calculated
52
Q

associate classic symptoms, exam findings, and urodynamic test results with each category of incontinence

A
Stress incontinence:
cough
sneeze
laugh
exercise
position change
Urgency:
urgency
frequency
nocturia 
dysuria

Mixed:
stress + urge
which is worse?

53
Q

how pelvic floor contraction exercises help reduce stress urinary incontinence

A

Levator ani muscles:

  • maintains constant tone
  • rapid contraction with cough, etc
  • relaxation with defecation/urination
  • massive expansion/stretching during labor with quick recovery to “normal
  • Type 1 fibers
  • –slow twitch
  • –maintain tone
  • –70% of the muscle
  • Type 2 fibers
  • –fast twitch
  • –rapid response to sudden increases in pressure
  • –30% of the muscle
54
Q

define intimate partner violence

A

IPV:
pattern of assaultive and coercive behaviors used by one person to maintain power and control over another person with whom an intimate relationship is shared- regardless of their legal status

multi-dimensional: violence can take different forms

pattern to violence

  • ongoing
  • partner has a sense of when and what forms of violence are going to happen (pattern)
  • impact on the survivor’s experience (how they’re experiencing the violence; experiencing fear? changing choices or behaviors as a result?)
  • not an individual incident

forms:

  • hands off
  • hands on
55
Q

statistics regarding epidemiology of IPV and its presentations

A

1/4 F have experienced domestic violence in their lifetime

600K to 6 million F are beaten each year by their boyfriends or husbands

F 20-24yo are at the greatest risk of experiencing nonfatal intimate partner violence

15.5 million American children live in homes where domestic violence occurred at least once during the year

Colorado numbers:

  • 70K emergency crisis calls
  • 120K nights of stay provided to 5.4k F, M, children
  • more than 13K were turned way from shelter for lack of space
  • 25.8K M,F,children provided counseling in a group or individual basis outside of shelter
  • 37 domestic violence related deaths in CO during 2014
56
Q

risk factors assoc w/ being abused and describe why reliance on risk factors is considered controversial in the context of screening

A

Individual:

  • perpetuator:
  • –Male
  • –abuse or witnessing marital violence as a child
  • –absent father
  • –alcohol use
  • Victim:
  • –pregnancy
  • –youth
  • –single/divorced/separating

Relationship:

  • marital conflict
  • male control of wealth and decision-making in family

Community:

  • poverty, low socioeconomic status, unemployment
  • associating w/ delinquent peers
  • isolation of F and family

Society:

  • norms granting M control over F behavior
  • acceptance of violence as a way to resolve conflict
  • notion of masculinity linked to dominance, honor, or aggression
  • rigid gender roles

Risk factors for IPV victims in the US:

  • pregnancy
  • young age
  • single, separated, or divorced status
  • NOT risk factors:
  • –SES status
  • –Race
  • –level of education
  • –employment
  • –insurance status

Associated characteristics: (assoc doesn’t mean causation)

  • mental illness
  • drug and alcohol abuse (by victim)
  • poor general health or chronic pain
57
Q

risk factors assoc w/ becoming an abuser

A

Risk factors for IPV abuser in the US:

  • Being Male
  • Alcohol, firearms, drugs (esp. stimulants)
  • Abuse or witnessing marital violence as a child
  • Social isolation
  • Less than high school education
  • Prior arrests
  • Absent Father
  • Young age
  • Low income, economic stress
  • Community with traditional gender norms or weak sanctions
  • Hierarchical jobs
58
Q

trauma and medical presentations of IPV

A

cycles of violence
power and control wheel

Physical – Injury & Medical:

  • Facial, fractures, dental, neurological - soft tissue, internal, “falls”
  • Chronic Pain (Back, abdominal, chest, head)
  • Fibromyalgia
  • Rapid heartbeat
  • Nausea or upset stomach
  • Increased susceptibility to illness
  • Hypertension

Further adult symptoms:

  • behavioral reactions
  • –sleep or appetite disturbance
  • –fatigue
  • –withdrawal or isolation
  • –grinding of teeth
  • –self harm
  • emotional
  • –shock
  • –fear/anxiety
  • –grief/guilt
  • –denial or minimization
  • –emotional outbursts
  • –overwhelmed
  • –diminished interest in activities
  • –feelings of powerlessness
  • psychological/cognitive
  • –difficulty concentrating
  • –slowed thinking
  • –difficulty making decisions
  • –confusion
  • –blaming self/others
  • –poor attention span
  • –disorientation
  • –memory difficulties
  • –nightmares
  • –distressing dreams
  • –suspiciousness

children exposed:

  • distress symptoms
  • externalized problems (aggression, antisocial behavior)
  • slowed or impeded “normal” brain development
  • suicide rates
  • witnesses (vs victims) are at greater risk of anxiety, depression, and other post-traumatic disorders
  • alcohol and drug abuse
  • poor school performance
  • teen pregnancy
  • use of violence as an adult

common child symptoms/rxns:
Physical - Headaches; Stomachaches, nausea; Chronic diarrhea; Tired; night terrors
Emotional - Anger; Self-blame; Nervous; Clingy; Attention-seeking; Detached; Isolated; Difficulties concentrating; Ambivalence; Fear of abandonment; Indecisive
Behavioral - Overly aggressive, disruptive, destructive; Mood swings; Overly Passive, flat affect; Parentified, perfectionist; Self-abusive behavior; Running away; Drug abuse

emotional trauma:

  • A hallmark of traumatic experience is that it typically overwhelms an individual mentally, emotionally, and physically
  • Is characterized by feelings of: • intense fear • helplessness • loss of control • threat of annihilation
  • Produces profound and lasting changes in physiological arousal, emotion, cognition, and memory
  • Is “in the eye of the beholder
  • Traumatic reactions are NORMAL reactions to ABNORMAL events
  • A trauma-informed approach is based on the recognition that many behaviors and responses expressed by survivors are directly related to traumatic experiences.

common trauma responses:

  • Hyper-arousal - Hypervigilance, panic attacks, difficulty concentrating, irritability to minor provocations; exaggerated startle reflex, constantly “on guard” or jumpy
  • Intrusion or re-experiencing events - intrusive thoughts, nightmares, flashbacks
  • Constriction or avoidance – Detachment, disorientation, denial
59
Q

legal and professional responsibilities of clinicians in management of he victim of abuse or IPV

A

current guidelines:

  • AMA: E-2.02 Physician’s Obligations in Preventing, Identifying and Treating Violence and Abuse (Appendix 2)
  • –“…should routinely inquire…”
  • –“…consider abuse as a factor in the presentation of medical complaints …[since it] may adversely affect…health status or ability to adhere to medical recommendations.”
  • JCAHO (Hospital Accrediting Agency)
  • –Requires hospital-wide standards for identification, assessment and response to victims
  • –Staff needs to be able to identify abuse, neglect
  • –Education plan for staff
  • –Integrated response within community, legal requirements

Mandatory reporting:
-Laws vary by state
-Colorado:
—All acute injuries thought to be due to injury due to an intimate partner must be reported to the police in jurisdiction of your office (not jurisdiction where injury occurred)
—But…?
—Is it a good idea? What do you think?
—for:
===Behavior doesn’t change without consequences
===Affirms a societal value that violence is wrong
===Takes “Don’t ask, don’t tell” out of physician repertoire
===Saves later morbidity/mortality
—against:
===Violates confidentiality, trust between patient, physician
===Not a nuanced response – victims often make very difficult but courageous choices
===May discourage victims from seeking care
===Unclear if it impacts violence or other outcomes
===Leaving is a high-risk time for violence
===Violates victim autonomy

Your Role - Elements of Appropriate Intervention:

  • Routinely inquire about abuse; Universal screening
  • Assessment for safety; Develop a safety plan
  • Document the abuse
  • Discuss options and resources
  • Provide advocacy and referral
  • Treat physical health problems
  • Provide for follow up care as indicated
60
Q

bladder grid questions

A

coughing
-stress

itching
-fistula

exercise
-stress

leak only when have full bladder
-normal, urgency, and overflow (water over the dam)

lifting
-stress

sneezing
-stress (squeeze before you sneeze)

stress
-urge

nocturne
-urge

urgency
-urgency

risk factors

  • chronic cough: stress
  • CT disorders: stress
  • excessive caffeine: urge
  • neuro: overflow