Laxatives, Anti-diarrheals, Anti-emetics, and Prokinetic Agents 1 and 2

Question 1

Bile Salt Binding Resins

Answer 1

Cholestyramine, Colestipol, Coleselvam

Question 2

What is MOA of bile salt binding resins:

Answer 2

In terminal ileum, conjugated bile salts, which may cause colonic secretory diarrhea.

Decrease caused by excess fecal bile acids by binding to these bile salts.

Question 3

Cholestyramine, Colestipol, Colesevelam

Answer 3

MOA: Binds bile salts and decreases diarrhea caused from excess bile salts reaching the colon.

Used primarily for hypercholesterolemia.

Question 4

Adverse Effects of the Bile Salt induced Diarrhea

Answer 4

Colesevelam does not appear to have significant effects on absorption of the drugs.

Binds drugs and reduces their absorption

decreases clearance of pathogens

Question 5

Probiotics

Answer 5

Competitionin the gut for pathogenic microorganisms for nutrients or adhesion sites, and possibly for secretion by probiotics of molecules that inhibit the growth of pathogenic microorganisms

Question 6

Probiotics Therapeutic application

Answer 6

antibiotic associated diarrhea

Question 7

Sulfasalazine MOA

Answer 7

Breakdown products are 5-ASA and Sulfapyridine.

5-ASA acts as an anti-inflammatory and anti-secretory. Inhibits prostaglandin and leukotriene. Scavange for oxygen radicals. Anti-secretory effects.

Question 8

Clinical Applications

Answer 8

Ulcerative colitis and diarrhea.

Question 9

What do you need with sulfapyridine?

Answer 9

Folic Acid supplementation

Question 10

Glucocorticoids

Answer 10

Anti-inflammatory effects and reduce cytokines