Laryngology Flashcards
Match the bronchial arch with it’s laryngeal derivative:
A. Corniculate, arytenoid and cricoid cartilages; some laryngeal muscles;RLN
B. Upper body of hyoid bone and less cornu
C. Epiglottis, thyroid cartilage, cuneiform cartilages, pharyngeal constrictors, some laryngeal musculature, SLN
D. Lower body of hyoid and greater Cornu
A. V/VI
B. II
C. IV
D.III
Position of infant larynx related to cervical vertebrae vs adult
Infant: C1-C4
Adult: C4-C7 (by age 4)
Name intrinsic laryngeal muscles, function and innervation
- Cricothyroid: lengthens VF, external SLN
- Posterior cricoarytnoid: abducts, RLN
- Lateral cricoarytnoid: adducts, RLN
- Oblique arytenoid: adducts, RLN
- Transverse arytenoid: adducts
- Thyroarytnoid: relaxes, shortens and adducts; RLN
Describe sensation of the larynx
Internal branch of SLN above the glottis and RLN below glottis. Tip of epiglottis receives innervation from IX
Describe subtypes of laryngeal epithelium
- Supraglottis: pseudostratified columnar epithelium (respiratory epithelium)
- Glottis: stratified squamous epithelium
- Subglottis: pseudostratified columnar
- Lingual surface of epiglottis: stratified squamous
- Laryngeal surface of epiglottis: stratified squamous merging into pseudostratified columnar
Jitter
Cycle to cycle variation in frequency
Shimmer
Cycle to cycle variation in amplitude
GRABS scale
Grade Roughness Breathiness Asthenia (lack of power) Strain
0- no déficit, 1- mild, 2-moderate, 3- severe
Five aspects evaluated by stroboscopy
Symmetry - appearance of VFs, symmetry of motion of one VF compared to the other
Periodicity - regularity of glottic cycles
Amplitude- lateral excursion of mid membranous cord, should be ~1/3 width of true VF
Mucosal wave- movement of the SLP
Closure- VF coming together
Common side effects of PPIs
Abdominal pain, diarrhea, nausea, osteoporosis, elevated liver function tests, headache, candidiasis
Vocal fold nodules
Benign growth in the superficial layer of the anterior and middle third of the true vocal fold which can be either acute (edematous, erythematous, or vascular) or chronic (firm non-vascular secondary to scar deposition and fibrosis).
- Seen at midportion of membranous VF (where shearing and collisional forces are greatest)
- Bilateral
- Tx: speech therapy followed by surgical removal if continued poor voice and persist nodules after > 3months of therapy
Vocal fold Nodules versus polyps
Nodules: Always bilateral,
composed of inflammatory tissue, respond to voice rest, have a broad range of appearances
Polyps: Unilateral or bilateral, full of either gelatinous material or blood, typically do not respond to voice rest.
Treatment of choice for vocal fold hemorrhage
This is a laryngologic emergency and the treatment is 7 to 14 days of total voice rest with follow up to ensure resorption of blood and identify a varix that could be treated. If the blood has not resolved chordotomy and a evacuation of blood are indicated.
Vocal fold scar versus sulcus vocalis
Vocal fold scar: the lamina propria is replaced with abnormally fibrous and disorganized tissue.
Sulcus vocalis: the lamina propria has degenerated or disappeared leaving an epithelial lined depression down to the vocal ligament or deeper.
What benign lesion often occurs on the posterior vocal fold near the vocal process as either an ulcerative or nodular polypoid process?
Vocal fold granuloma
True or false the polypoid changes associated with Reinke Edema are permanent?
True however the degree of edema and turgidity may fluctuate with voice use and exacerbating factors
Intracortical vocal fold cysts
Usually arise within the superficial lamina propria (although can arise from the vocal ligament or epithelium). They may be open to the epithelium of the vocal fold and can be associated with a sulcus, they are also commonly associated with a contralateral nodule. Two types: mucous retention cysts (wax and wane) and epidermoid/Keratin cysts (fairly stable)
A cyst involving which branchial cleft may involve the larynx
Third branchial cleft
Laryngeal saccule
A blind sac between the false vocal fold and the thyroid cartilage, which opens into the anterior third of the laryngeal ventricle, is lined with ciliated respiratory epithelium and mucous glands. It is responsible for lubricating the vocal folds.
Anterior versus lateral saccular cysts
Anterior: Extend mediately into the laryngeal lumen between the true and false vocal folds
Lateral: Extends posteriorly and superiorly to involve the aryepiglottic fold
Laryngocele versus saccular cyst
Laryngocele: Air filled dilation of the saccule that communicates with the laryngeal lumen
Saccular cyst: Fluid filled dilation of the saccule that does not communicate with the laryngeal lumen
Internal versus external/combined laryngocele’s
Internal: Contained within the thyroid cartilage
External: Extends through the thyrohyoid membrane
Treatment of laryngeal saccular cyst vs laryngocele
Saccular cyst: marsupialization or complete Excision
Laryngocele: complete excision vía endoscopic or external approach.
-Marsupialization not recommended
What is a laryngopyocele and how is it managed?
A saccular cyst filled with purulent debris. Can be a surgical emergency. Secure and airway and drain and culture. Either at the time of drainage or after acute infection complete excision of cyst. Medical management of acute episode with IV antibiotics, antipyretics and steroids.
Describe normal changes that occur in larynx with age and which physiologic changes contribute to “elderly voice”
Muscle atrophy, thinning of the vocal ligament, mucous glad degeneration, cartilage ossification, epithelial thickening.
Air escape, tremor, laryngeal tension
In a patient with paresis of external branch of the left superior laryngeal nerve, which direction will the petiole of the epiglottis deviate during high pitched phonation?
Left. Toward the side of the weak cricothyroid muscle.
Three habits to limit or eliminate to improve laryngeal hygiene
Alcohol, tobacco, caffeine
Common symptoms associated with reflux laryngitis
Globus, hoarseness, cough, throat clearing
Fewer than 50% have GI symptoms of reflux
Laryngeal chondromas arise most commonly from what anatomical site?
Posterior cricoid plate
Cotton Myers Subglottic Stenosis grading system
Grade 1- 0-50%
Grade 2- 51-70%
Grade 3- 71-99%
Grade 4- 100%
Treatment for laryngeal chondromas
Complete excision to negative margins alone
Most common benign neurogenic laryngeal neoplasms
Laryngeal schwannoma (most common), neurofibroma, granular cell neoplasm
Schwannomas and neurofibromas most commonly arise from internal branch of SLN
Where do endolaryngeal neurofibromas commonly present
Arytenoid complex and AE fold
Which neurogenic laryngeal neoplasm is often associated with pseudoepitheliomatous hyperplasia of overlying mucosa, which can often be misdiagnosed as SCC?
Granular cell neoplasm
- Misdiagnosis due to insufficiently deep biopsy
- Most common site is middle to posterior part of TVF
- Treat with complete local excision
Because granular cell tumors present a risk for malignant conversion (2-3%) they should be resected. What confirmatory findings for benign tumor is seen on pathology?
Large polyhedral cells that may contain significant collagen, granular eosinophilic cytoplasm, centrally locates vesicular nuclei
+periodic acid Schiff (PAS), +S-100, + neuron specific enolase, + NK1-C3
What is the likely cell origin for granular cell tumors
Schwann cell
Most common benign neoplasm of larynx
Recurrent respiratory papillomatosis (RRP)
HPV 6 &11 are most common subtypes. 11 tends to be more aggressive requiring more frequent surgical intervention and higher incidence of airway obstruction.
Describe structure of HPV
Pappilomavirus, non enveloped icosohedral capsid, double stranded DNA virus
True or False. Both cystic hygromas and cavernous/microcystic lymphangiomas respond well to surgical excision?
False
Cystic hygromas: composed of large cysts that are amenable to surgical excision.
Cavernous/microcystic lymphangiomas: composed of very small cysts difficult to resect and tend to recurr after surgery.
Which side to laryngeal hemangiomas more commonly present in the larynx?
The left
How are laryngeal hemangiomas diagnosed and what is their natural history? Treatment?
Seen on exam covered by thin, friable mucosa overlying a vascular stroma. T2 weighted MRI can be helpful to delineate extent. Most commonly seen in surpgalottis in adults and do not spontaneously regress. Hemangiomas in adults should not be actively treated unless symptomatic. Steroids or radiotherapy may be considered if necessary.
At what age to infantile hemangiomas typically begin to involute and at what age is involution likely to be complete?
Between 12-24months of age; 50% will be involuted by age 5 and 70% by age 7.
Viruses associated with acute viral laryngitis
RSV, parainfluenza, influenza, adenovirus, HSV, coronavirus
What med has been shown to improve discomfort with acute viral laryngitis?
NSAIDs (Flurbiprofen lozenges)
Treatment of acute viral laryngitis
Supportive (hydration and voice rest). A single dose of dexamethasone (0.16mg/kg) has been shown to decrease severity of moderate to severe laryngotracheitis in peds during first 24hrs after injection.
Infectious agents causing epiglottitis in adults
Bacterial: H influenzae type B and other strains, Strep penumo, Staph aureus, B hemolytic strep
Viral: HSV, varicella zoster, prainfluenza, influenza, EBV
Fungal: candida
Most common cause of acute fungal laryngitis
Candida albicans
Causes of chronic fungal laryngitis
- Blastomycoces (southern US): broad based budding yeast on pathology
- Histoplasma (Ohio and Mississippi River Valley): typically seen in immunocompromised secondary to HIV, post transplant or diabetes
- Coccidioides (SW US and Mexico - Valley fever)
- Paracoccidioides: seen in South American male farm workers. Ulcerative and exophytic lesions seen on exam
- Mycobacteria (South America, Africa, Asian subcontinent): true and false vocal folds most commonly affected sites
- Cryptococcus
- Candida
What is the most common subsite affected by laryngeal sarcoidosis?
Epiglottis
*Laryngeal sarcoidosis can occur in isolation without evidence of disease elsewhere in the body (1-5%)
What is the pathognomonic finding of laryngeal sarcoidosis during laryngoscopy?
Diffuse pale, edematous enlargement of the supraglottis
ACE level and sarcoid
Useful for monitoring disease but not recommended as diagnostic test due to low sensitivity (60%).
What % of patients with granulomatosis and polyangiitis will develop subglottis stenosis?
10-20%
Expected biopsy findings in a patient with granulomatosis with polyangiitis?
Necrotizing granulomas and necrotizing vasculitis of small arteries, arterioles, capillaries and venules
What will the flow volume loop look like in a patient with subglottic stenosis?
Flattened inspiratory and expiratory phases indicating a fixed obstruction.
What is most common laryngeal subsite affected by amyloidosis ?
True and false cords and ventricles
What autoimmune disorder results in episodic severe and progressive inflammation of cartilage most commonly within the ears, nose and laryngotracheobronchial tree?
Relapsing polychondritis
What is the most common manifestation of airway involvement in relapsing polychondritis?
Tracheobronchomalacia
What % of patients with RA develop cricoarytnoid joint involvement?
25-30%
What % of patients with RA have radiologic evidence of cricoarytnoid joint involvement?
54-72%. The common findings on CT are cricoarytnoid prominence, density, and volume change, subluxation, decreased joint space, and Pyriform sinus narrowing.
Radiologic involvement does not correlate with symptoms
Treatment for RA cricoarytnoid joint dysfunction
High dose corticosteroids or immune modulating meds.
Motor neurons for RLN originate in what brain stem nucleus?
Nucleus Ambiguous
Most common cause of unilateral true vocal fold paralysis.
Surgical iatrogenic injury
Most common malignant cause of unilateral true vocal fold paralysis?
Lung carcinoma
Imaging of what region should be obtained to evaluate unilateral true vocal Fold immobility of unknown cause
Skull base to upper chest to examine full course of recurrent laryngeal nerve
What meds are known to have neurotoxic effects that can lead to true vocal fold paralysis?
Vinca alkaloids (vincristine, vinblastine) and cisplatnum
After a high vagal injury, will the palate elevate away or toward the injured side?
Palate will elevate away from injured side
Patient is evaluated for hoarseness and aspiration after suffering a known stroke involving the posterior inferior cerebellar artery what is likely to be seen on flexible laryngoscopy?
Paralysis of ipsilateral true vocal. Wallenberg syndrome or lateral medullary syndrome, dysphagia, loss of pain, and temperature sensation on the ipsilateral face and contra lateral body and ipsilateral Horner syndrome.
What is the role of laryngeal EMG in management of vocal fold immobility?
EMG Can differential paralysis from fixation and may provide prognostic information regarding potential for recovery.