Facial Plastics Flashcards
What are the layers of the epidermis from superficial to deep?
Stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, stratum basale
What is the predominant type of collagen in the basement membrane?
Type IV collagen
Three phases of wound healing
Inflammation - vasodilation from injury to one day; cellular response from 30 min to 1 week
Proliferation - reepithelialization from 30min to one week, fibroplasia/collagen synthesis from 1 day to 3 weeks, wound contraction from 1-3+ weeks
Remodeling - scar collagen remodeling from 3 weeks to 1 year
Four general categories of wound healing
Primary intention: two wound edges are brought together as the primary intention of the surgeon
Delayed primary healing: two wound edges reapproximated at a later time
Secondary intention: A full thickness wound where edges are not reapproximated and wound is allowed to heal by granulation and contracture
Epithelialization: occurs in partial thickness wounds as epithelial cells migrate and replicate over the wound
Cell types primarily involved in inflammatory phase
After vasoconstriction and subsequent vasodilation, PMNs arrive and predominate for first 24-48hrs. Then monocyte migration occurs
What type of cell synthesizes collagen?
Fibroblasts
What cell type is responsible for wound contracture during healing?
Myofibroblasts containing microfilaments capable of producing contractile forces. These cell predominate fibroblast population during second week of wound healing.
What major events occur during proliferative phase of wound healing?
Re-epithelialization, neovascularization, collagen deposition, wound contracture
During which phase of healing are keratinocytes, fibroblasts and endothelial cells recruited to the wound?
Proliferative phase
During the proliferative phase, which cytokine modulates angiogenesis and neovascularization?
Vascular endothelial growth factor (VEGF)
How does hyperbaric oxygen therapy encourage wound healing?
It promotes angiogenesis, fibroblast proliferation, leukocyte activity, and is synergistic with antibiotic therapy.
What is the predominant type of collagen in an early scar?
Type III
What is the approximate tensile strength of a healing wound at 3 months?
50% of normal tissue
When is the remodeling phase of wound healing usually complete?
1 year
Tenets of Halsted?
- Gentle handling of tissues
- Aseptic technique
- Sharp anatomical dissection of tissues
- Care hemostasis, using fine, nonirritating suture materials in minimal amounts
- The obliteration of dead space in the wound
- Avoidance of tension
Local tissue factors that can impair wound healing?
Any tissue effect that decreases oxygenation, increases infection risk, prolongs inflammation, delays neovascularization or alters normal process of healing. I.e. local infection, ischemia from pressure necrosis (diabetic neuropathy, hematoma), h/o radiation resulting in alteration of tissue structure, locally destructive processes (neoplasia, wound desiccation). Also patients with pmh of chemo/radiation, on immunosuppression, or diseases which affect vasculature (diabetes, PVD, tobacco dependence) are at increased risk of wound complications.
What are some of the performance differences between monofilament and braided suture?
Monofilament has memory and usually requires more knots to secure a tie. Braided has more tensile strength but creates more resistance through tissue, induces a stronger inflammatory response and is more likely to serve as a reservoir for microorganisms.
What type of surface contour is most favorable for wound healing by secondary intention?
Concave surfaces (concave surfaces of the nose, eye and ear usually have excellent results)
What are some surgical options for scar revision?
Excision and closure with straight line, broken geometric line, W plasty, Z plasty, or local flap; excision and placement of a skin graft.
What medications may be injected into a scar to improve its appearance?
Steroids (triamcinolone i.e Kenalog), antimitotic agents (5-FU, bleomycin)
What is the role of silicone in scar revision?
The mechanism of action is not entirely known. Hypotheses include that direct pressure exerted by silicone sheeting decreases scar hypertrophy, or that silicone’s ability to maintain a hydrated environment inhibits fibroblast production of collagen and glycosaminoglycans.
Treatment options for keloids and hypertrophic scars
Occlusive dressings, intralesional steroid injections, cryotherapy, radiation therapy, 5-FU, Botox injection, tacrolimus, retinoic acid, laser therapy, re-excision combined with above treatments
What is dermabrasion and what is its role in scar revision?
Dermabrasion is a mechanical method of removing the epidermis and creating a papillary to upper reticular dermal wound. Injuries to the epidermis and papillary dermis heal without scarring. Dermabrasion changes the depth of the scar to help it blend with surrounding tissue. It also seeks to create a wound with texture and color closely matching normal skin.
What layer of the dermis contains the predominant blood supply of the skin?
Reticular dermis