Large Intestine Flashcards

(30 cards)

1
Q

how long is the large intestine

A

1.7m

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2
Q

what is the large intestine comprised of

A

caecum, appendix, colons, rectum, anal canal and anus

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3
Q

what is the taeniae coil

A

longitudinal smooth muscle layer in caecum and colon that is divided into 3 strands

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4
Q

where is smooth muscle thickened

A

internal anal sphincter

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5
Q

what Is the internal anal sphincter surrounded by

A

skeletal muscle of the external anal sphincter

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6
Q

what is the haustra

A

sac like bulges due to activity of teaniae coli and circular muscle layers

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7
Q

what permits entry of material from terminal ileum to caecum

A

gastroileal reflex

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8
Q

when does the one way ileocacecal valve relax

A

reponse to distention of the duodenum

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9
Q

when does the one way ileocacecal valve contract

A

response to distention of the ascending colon

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10
Q

what type of tissue does the appendix contain lots of

A

lymphoid

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11
Q

what can happen when the appendiceal orifice is obstructed by a faecalith

A

appendicitis

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12
Q

what does the colon absorb

A

Na+, Cl-, H2O, short chain fatty acids

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13
Q

what happens to carbohydrate not absorbed by the small intestine

A

it is fermented by colonic flora to short chain fatty acids

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14
Q

what does the colon secrete

A

K+, HCO3-, mucus

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15
Q

what increases surface area of the colon

A

colonic folds
crypts
microvilli

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16
Q

what are coloncytes

A

surface epithelial cells of colon

17
Q

what do coloncytes mediate

A

electrolytes absorption by osmosis drives absorption of water.

18
Q

which cells mediate ion secretion

19
Q

what does mucus contain

A

glycosaminoglycans hydrated to form a slippy surface gel and secrete trefoil proteins involved in host defence

20
Q

what do glycosaminoglycans form and secrete

A

hydrated to form a slippy surface gel and secrete trefoil proteins involved in host defence

21
Q

what hormone enhances sodium ion absorption and potassium ion secretion

22
Q

what is no propulsive segmentation

23
Q

difference between haustartion and segmentation

A

haustartion has a much lower frequency contributing to a long transit time

24
Q

where does mass movement occur

A

ascending and transverse colon

25
what do gut commensals synthesise
vitamin K12 and free fatty acids
26
what type of disease is IBS and IBD
chronic bowel disease
27
symptoms of IBS
diarrhoea constipation abdominal pain
28
what is the treatment for IBS
symptomatic treatment diet adjustment diarrhoeals/laxatives Linaclotide
29
when is Linaclotide used
moderate to severe IBS with constipation
30
treatment of IBD
glucocorticoids for acute attacks | aminosalicytes