Laminitis Flashcards
What is laminitis?
Inflammation of the soft tissue of the hoof
What is the laymens term for laminitis?
Founder- typically refers to the chronic process
What is the classic experimental model for laminitis?
CHO overload
Gave rise to the Obel lameness grading system
T/F: Laminitis has specific sex and breed predilections.
No- some correspondence to weight to foot size though
T/F: Laminitis is typically not seen in young animals.
True
What are some classical signs of laminitis?
Heat in feet, palpable digital pulses, splayed stance
Do younger or older animals typically respond better to symptomatic laminitis therapy?
Younger- in older animals it’s typically a secondary condition and symptomatic treatment will not be as effective
What are some primary causes of laminitis?
Sepsis, endocrinopathies, trauma (road founder)
What plant toxicity discussed is known to cause laminitis?
Black walnut extract
Reasons why dark wood bedding is avoided in stables
What poundage of grain at one time may result in CHO overload syndrome?
> 4lb
Grazing what kind of pastures can result in development of laminitis?
Lush green pastures, higher non-structural CHO content
What are some sepsis related causes of laminitis?
Endotoxemia, SIRS, GI disease, black walnut toxicity, CHO overload
What kind of endocrinopathies can result in laminitis?
Anything in results in an increase in circulating glucocorticoids
PPID, equine metabolic syndrome, exogenous administration
What is road founder syndrome?
Non-weight bearing lameness in one foot causing excessive concussive force on the contralateral foot
What is the pathophysiology of laminitis?
Structural failure of the attachment between the epidermal laminae and the dermal laminae resulting in the loss of suspension of the foot within the hoof
T/F: Laminitis may be associated with systemic illness or with local factors.
True- stress, concussive forces, endotoxin, steroid use, trauma, etc
T/F: Regardless of the cause, the process and end result of laminitis is the same.
True
Why does SIRS cause laminitis?
- Leukocyte infiltration/migration to laminae
- Uncontrolled activation of metalloproteinases
- Vasculitis
What enzymes are directly involved in controlled detachment of laminae as required for normal hoof growth?
Matrix metalloproteinases
What is the vascular hypothesis towards the development of laminitis?
Initial development of reduced perfusion and digital ischemia followed by constriction of digital circulation culminating in the development of lameness
T/F: According to the vascular theory, any vascular issues are secondary to inflammatory mediators.
True
What clinical signs of laminitis support the vascular theory?
Reflex hyperemia and development of increased hoof temperature
What manifestations of compartment syndrome are found in laminitis?
Development of edema, swelling, and cell death which can be self-perpetuating
Is there experimental support for reperfusion injury implicated in laminitis?
Yes- production of oxygen free radicals that contribute to cell death and inflammation upon reperfusion of a hypoxic environment
What denotes the development of a chronic laminits?
Structural failure- earliest signs are microscopic and can develop into a gross lesion and clinical disruption
Why is hyperinsulinemia theorized to contribute to development of laminitis?
Results in the sensitization of the structures of the hoof so that they are at increased risk for laminitis
Could hyperinsulinemia be a contributer to the pathophysiology of sepsis and endotoxemia?
Yes
What is though to be central to the mechanism of endocrinopathies in causing laminitis?
Glucose metabolism dysfunction
T/F: Hyperinsulinemia also results in vascular dysfunction which can contribute to inflammatory mechanisms of laminitis.
True
What are some proposed causes of traumatic laminitis?
- Traumatic tearing of tissues
- Traumatic induced vasospasm
- Tissue fatigue and vasocompression (in unilateral weight bearing)
What are the major forces involved in disruption of the laminae?
Vertical load, shear forces, tensile forces, and solar fulcrum
What is the dominant factor for displacement?
Vertical load
What is the vertical load dependent on?
Weight of the horse and the size of the foot
Heavier horses with smaller feet have an increased vertical load which may predispose them to laminitis
What is rotational displacement mostly attributed to?
Tensile forces from the pull of the deep digital flexor on P3
What contributes additionally to rotational displacement of the hoof?
Lack of sufficient dorsal hoof dermal-epidermal interface
T/F: The heel growing faster than the toe has a tendency to make heel lengthen and causes flexion of distal interphalangeal joint
True
What type of displacement has a poorer prognosis: vertical or rotational?
Vertical
T/F: Vertical displacement is often associated with damage/disruption throughout the entire foot.
True
Is P3 typically in a fairly normal position in vertical displacement?
Yes
In what kind of displacement is it possible for a horse to entirely lose a hoof?
Vertical displacement
What is typically the presenting complaint in laminitis?
Lameness and reluctance to move/walk
What is the typical stance in acute laminitis cases?
Standing in one place continually shifting weight with the front feet forward and more weight loading on the heel