Lactation & Breastfeeding Flashcards
Sir Ashley Cooper was wrong about the presence of….
Lactiferous sinuses (they do NOT exist)
The functional component of the breast
glandular tissue
It is possible for milk to be drained from behind a clog because….
it is UNLIKELY that the problematic lobe is drained by a single duct
Ducts and glands of the breast are both types of _____ tissue in the breast
glandular
Fibroblasts, adipocytes, blood vessels, plasma cells, and nerve are all types of ______ tissue in the breast
stromal
In the third trimester, the epithelial cells lining the breast alveoli differentiate into….
secretory cells, capable of milk production
Milk is stored in the alveoli until it can be expressed through the….
ducts (branching ducts > terminal ducts), which deliver milk from the alveoli to the nipple
Majority of milk is produced while…..
the infant is feeding
Each duct directly connects to around _______ lobes
10-15 lobes
Each lobe contains ~ _____ alveoli
10-100 alveoli
All lactational structures are [deep vs. superficial] to the pectoralis muscles
superficial
Support the breast by connecting the chest wall to the skin surface
Cooper’s ligaments
(2) hormones responsible for relaxation and stretching of the Cooper’s ligaments during pregnancy
relaxin, progesterone
Artery that feeds the blood supply of the breast
internal mammary artery (internal thoracic artery)
Sebaceous and lactiferous glands opening on and around the areolas
Montgomery tubercles
Proteins in human milk (3)
casein, whey, IgA
Type of sugar in human milk
lactose (native species lactose intolerance is rare)
Prolactin is produced by the….
anterior pituitary gland
Embryogenesis of breast development
4 weeks - breast ridge
18 weeks - buds appear
Secondary buds elongate, eventually canalize, forming a rudimentary duct system. As the fetus lays down more subcutaneous fat, the stored fat plays a critical role in allowing the ducts to extend and elongate.
Congenital condition in which infant is born with extra nipples along the original mammary ridge
supernumerary nipples
Why may infants have transient secretions from their nipples in first few days of life
r/t exposure to circulating maternal hormones like prolactin around the time of birth
After birth, the development of breasts is called…
mammogenesis
Mammogenesis during prepubescence is largely limited to….
fat deposition (no duct development)
Changes to the breast during puberty
fatty tissue growth, increase in mammary tissue volume/size, maturation of the terminal duct-lobe units (lobuloalveolar development)
Changes to the breast during puberty are driven by the influence of (3)
progesterone, estrogen, prolactin
______ marks the final phase of mammogenesis
pregnancy
Estrogen and progesterone are not directly involved in lactation, but contribute to lactation by…..
helping proliferate the cells needed for milk production
Changes to the external breast structures during pregnancy (3)
areolar pigmentation, enlarged montgomery tubercles, skin appears thinner with vessels more prominent
Changes to the internal breast structures during pregnancy (3)
ductal system proliferates, lobules increase in size, epithelium transforms
Stage of breast development that begins in embryo and is completed during pregnancy
mammogenesis
Stage of breast development that begins mid-pregnancy and is completed by day 8 postpartum
Lactogenesis Stage 1 - 2
Stage of breast development that begins day 9 postpartum and continues until weaning
Lactogenesis stage 3 (galactopoiesis)
Stage of breast development from commencement of weaning
involution
Lactogenesis I occurs…..
mid-to-late pregnancy
Lactogenesis II occurs…..
postpartum
Stage of lactogenesis marked by differentiation of the alveolar cells from secretory cells, producing colostrum
Lactogenesis I