Labs Flashcards

1
Q

the test has a low rate of false negatives

A

sensitive test

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2
Q

this test is used is used to measure the diseased cohort (sick patient and you are looking for cause)

A

sensitive test

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3
Q

this test has a low rate of false positives (used on healthy population/pha labs)

A

specific test

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4
Q

formula for T 1/2 beta ?

A

(0.7 x Vd)/clearance

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5
Q

what happens to the vessel when lesion at site?

A

vasoconstriction distal
vasodilation proximal

increased WBC to localized area of injury

vasodilation caused by prostacyclins and PGE2 to mobilize WBC to the site of injury

vasoconstriction caused by thromboxane and leukotrienes to prevent spread of infection to systemic

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6
Q

triad for inflammatory process?

A

increased WBC CRP ESR

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7
Q

Where is crp synthesized?

A

liver
because of inflammatory response
cytokines

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8
Q

best biomarker for renal function?

A

creatinine excreted entirely by kidneys and is directly proportional to renal excretory function.
inversely proportional to GFR

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9
Q

normal GFR?

A

125ml/min

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10
Q

where is the majority of calcium found

A

bones

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11
Q

If major Duckwork gave double the dose of insulin what would oppose the effects?

A

glucagon
epinephrine
cortisol
GH

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12
Q

What is anion gap?

A

normal 8-16
measure of plasma anions chloride and bicarb

lactic acid using up bicarb

Na - Cl + bicarb

anion gap =ketoacidosis, lactic acidosis, renal failure
non anion gap= mudd butt, renal tube acidosis, renal failure

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13
Q

Important roles for calcium?

A

neurotransmitter
cardiac myocytes inotropy and chronotropy
muscle contraction
coagulation

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14
Q

anesthetic gas that causes birth defect

A

nitrous oxide

methionine

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15
Q

who is the false calcium?

what does it do?

A

magnesium

see decreased physiologic responses associated with Ca
relaxes smooth muscle

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16
Q

what ion inhibits presynaptic ach release and potentiates NDNMB?

how much do you reduce the dose?

A

hypermagnesemia

1/3 to 1/2

17
Q

the major extracellular cation responsible for osmotic pressure that maintains ECF volume?

A

sodium

18
Q

serum osmol equation?

A

2 times sodium plus glucose divided by 18

19
Q

when ECF volume increases the kidneys increase sodium excretion. What is the MOA?

A

ANP promotes sodium excretion
BNP promotes sodium excretion
Renal vasodilation promotes NaCl and H2O excretion

20
Q

when ECF volume decreases the kidneys increase sodium retention. What is the MOA?

A

RAAS promotes Na retention

B1 kidney, renin, granular cells, sodium reten

21
Q

… Baby girl
Whats your name
Let me talk to you

A
Let me buy you a drink
I'm t-pain, you know me
Konvict music nappy boy ooh wee
I know da club close at 3
Whats the chance of you rollin wit me
Back to the crib
Show you how I live
Lets get drunk forget what we did
… I'mma buy you a drank
Then i'mma take you home with me
22
Q

this electrolyte imbalance causes increased sensitivity to NMB non-depolarizing

A

hypokalemia

23
Q

best indicator for cardiac myocyte ischemia ?

A

Troponin

24
Q

what enzyme specific for cardiac

A

CKMB

25
Q

CKMB
rise
peak
clear

A

4-8 h
10-24h
24-36 h

26
Q

Troponin T and Troponin l
rise
peak
clear

A

4-6 h
10-24 h
10-15 days

27
Q

most specific tests for liver?

2

A

albumin

PT

28
Q

anesthetic with lowest solubility

A

desflurane

29
Q

anesthetic associated with renal issues?

A

sevo

compound A

30
Q

what property of LA best reflect toxicity?

A

concentration

31
Q

What labs most reflect fluid balance?

4

A

Hbg/Hct
Na
osmolality
lactate

32
Q

Interference with the Na K ATPase pump from ischemia or hypoxia lead to _______/_______ tissue lack of energy _______, _________,_________and _________

A

Interference with the Na K ATPase pump from ischemia or hypoxia lead to hypoperfusion to tissue, lack of energy, hypoxia, hyperosmolality intracellularly, cell swelling, and death