Lab Detection of Muscle Dz

Question 1

Creat Kinase is specific to __________?

Answer 1

skeletal, cardiac and smooth

It’s in CNS cells too but injury doesn’t increase serum CK

Question 2

Causes of increased serum CK?

Answer 2

skeletal muscle injury
cardiac muscle injury
muscle catabolism (anorexic cats)

Question 3

CK kinetics

Answer 3

increases rapidly after injury (peaks 6-12 hours in blood)
very short half life
persistent increases in CK indicate ongoing muscle damage

Question 4

Why might AST be increased?

Answer 4

muscle or hepatic injury

mild increases in dogs due to drug induction

Question 5

How could you differentiate AST being increased from liver injury vs muscle injury?

Answer 5

relative serum increases of both CK and AST indicate active ongoing muscle injury
Increases in AST alone could indicate previous muscle or hepatocyte damage

Question 6

Would an increase in ALT result from muscle injury

Answer 6

only if it’s severe liver damage

Question 7

What would you see on a UA when there’s muscle damage

Answer 7

dipstick + for hgb, neg ammonium sulfate precipitation test, clear serum