Intro to Enzymology Flashcards

1
Q

What are the leakage enzymes?

A
ALT
AST
SDH
GLDH
CK
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2
Q

What are the induced enzymes?

A

ALP

GGT

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3
Q

CK is _____ specific

A

muscle

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4
Q

Do CNS injuries raise serum CK?

A

No!

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5
Q

AST highest activity is associated with

A

skeletal and cardiac muscle

hepatocytes

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6
Q

Causes of increased serum CK

A

skeletal muscle injury (necrosis, IM inj, trauma, strenous excercise)
commonly seen in “down” cows/horses
cardiac muscle injury
muscle break down (catabolism) - severly anorexic cats

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7
Q

Ck kinetics

A

increases rapidly after injury
-peaks 6-12 hrs
Very short 1/2 life
-

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8
Q

Would anorexia and malnourishment in a cat lead to an increased CK

A

Yes! And it will decrease significantly w/i 48 hrs of re-feeding

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9
Q

Which increases faster, CK or AST? Which is more muscle specific?

A

CK is faster

CK is more muscle specific

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10
Q

Can ALT increase with severe muscle damage?

A

Yep! skeletal muscle is 5% of liver ALT activity

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11
Q

Myoglobin is released from _______

A

dead, dying muscle

generally severe, acute injury

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12
Q

How can you distinguish between myoglobin and hemoglobin on UA?

A

anemia = hgb
increased ck = myoglobin
myoglobin = clear serum
myoglobin does not percipitate w/ ammonium sulfate

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