Lab 8 - Muscle Memory Paper Discussion Flashcards
3 things submitted in cover letter with article for peer review
- -agree it is not submitted elsewhere for publication
- -all authors give approval
- -names/addresses of potential reviewers
what makes it easier to retrain vs 1st training?
increased number of nuclei
why are muscle cells multinucleated?
they are very large cells - needed for protein synthesis
how did authors define myonuclei when it came to staining?
geometric dystrophin ring
what is ablation of major synergist? why?
removal of helper muscle cell; to overload extensor digitorum longus cells
evidence that formation of new nuclei is not necessary for hypertrophy?
increase in protein synthesis long before formation of nuclei
what does paper infer about use of anabolic steroids?
the effects are permanent
Fig 1B
the number of nuclei increase before cross section area increases, supports cause and effect
where are new myonuclei coming from?
satellite cells
In figure with bar graphs where “b” is over two bars, what does b mean?
the results are statistically indistinguishable
which cells undergo apoptosis?
satellite cells, stromal cells
problem with Fig 1C
tested null hypothesis on same data that caused them to form hypothesis, need to test random process with new set of data
