Lab 8 Intestinal and pancreatic function

Question 1

Great role in intestinal motility

Answer 1

Autonomous nervous system

Question 2

Parasympathicomimetic, parasympatholytic and sympathomimetic drugs - act locally through? What is also working here

Answer 2

Plexus myentericus Auerbachi, submucosus Meisneri and act at the end plates

Components of feed (ex fiber) and temp. of feed are also acting through these plexi and end plates (some intestinal irritants ex foreign bodies -> severe muscular contraction -> development of ileus)

Question 3

Ileus?

Answer 3

Persistent inhibition of aboral transmission of gastric or intestinal contents
- Severe spastic muscle contraction may cause decreased blood perfusion and necrosis of the intestinal wall at the site of ileus

Question 4

Increased parasympathomimetic effect; local effect

Answer 4

• Increased SM contraction (peristalsis and secretory function up)
• Increased intestinal metabolism causes increased gas formation and gas accumulation cranially from the effect

Question 5

Increased parasympathomimetic effect; systemic effect

Answer 5

• Increased acetylcholine effects
• Increased muscular (SM and striated), irritability
  ex. treatment of myasthenia gravis

Question 6

Increased parasympathomimetic effect; drug

Answer 6

Neostigminum methylsulphuricum, physostigminum (Stigmosan injection)

Question 7

Increased parasympatholytic effect; drug

Answer 7

• Atropinum-sulphuricum

- N-butil scopolamine-bromide (Buscopan injection)

Question 8

Increased parasympatholytic effect; local effects

Answer 8

• Relaxing intestinal muscles -> decrease peristalsis and secretory function

Question 9

Increased parasympatholytic effect; systemic effects

Answer 9

• Decreased parasympathetic tone

Question 10

These parasympatholytic drugs should not be used in vet med practice for the treatment of gastrointestinal hypermotility and hypersecretion ex. enteritis, because?

Answer 10

Due to the danger of bacterial overgrowth and absorption of toxic materials