Lab 3 Flashcards
In organometallic reagents, the metal carries a partial—– charge and the carbon atom carries a partial——charge.
positive, negative
Organolithium reagents are —– reactive than organomagnesium reagents because the electronegativity difference between carbon and lithium is —– than the electronegativity difference between carbon and magnesium
more, greater
A carbanion (such as CH3- ) is the conjugate base of a very weak acid (CH4). This makes it a —— base.
strong
Organometallic reagents are made by mixing the metal with a(n)
alkyl/aryl halide
The formation of a Grignard reagent occurs through a(n) ___________________ mechanism.
radical
Solvent plays an important role in Grignard formation. The ——– atom on diethylether or THF will coordinate to the metal through the———.
.
oxygen, lone pair
Grignards react with ——- to form alcohols
carbonyls
Grignards react with O2 to produce ——– .
peroxides
Grignard reagents react with carbon dioxide to form ————– .
carboxylic acids
Use a graduated cylinder to measure reagent volumes ——- than 1 mL and a syringe to measure reagent volumes ——- than 1 mL.
greater, less
You need to add —— at the conclusion of the Grignard reaction to get the neutral product.
acid
You will isolate the product by performing an extraction. When you add your product to the separatory funnel and add methyl tert-butyl ether, your product will be in the ——- layer.
top
How will you get rid of the biphenyl by-product?
recrystallization
You will characterize your product using:
melting point and TLC
To exclude air/moisture from this reaction, we will use
a drying tube
