Lab 10: One Compartment Model- Multiple Doses

Question 0

How long are approximate steady state conditions achieved if a fixed daily dose is given ?

Answer 0

4-5 half lives

Question 1

Why are multiple doses clinically relevant?

Answer 1

Most drugs are given to patients for periods of months or years
E.g. Digoxin, anticonvulsants, antihypertensives

Question 2

What can be done to reach the target concentration quicker ?

Answer 2

Give the patient a loading dose along with a constant rate infusion to maintain the target concentration

Question 3

What are the 3 different experiments conducted in this lab?

Answer 3

Infusion - constant rate infusion of drug into the jug
Bolus - rapid injection immediately followed by starting a constant rate infusion
Multiple bolus doses - initial rapid injection is given at set intervals by further injections of the same size.

Question 4

What is the difference between target concentration and CSS?

Answer 4

Target concentration is the desired concentration which is able to produce, at the very minimum, a satisfactory therapeutic effect with minimal side effects.
The CSS is the concentration where the input rate of the drug is equivalent to its elimination rate.

Question 5

How do you calculate the bolus dose to achieve a certain target concentration?

Answer 5

Bolus dose = target concentration x volume of distribution

Question 6

What is the significance of T75?

Answer 6

It takes 2 half lives to reach 75% of the Css