LA Flashcards
Why do we use LA?
- Pain control
- Control bleeding
- Symptom relief for those with facial pain
How does LA work within a nerve cell?
Unionised LA are lipid soluble so can diffuse across the lipid cell membrane.
Once inside the nerve cell, the LA molecule comes ionised due to the pH within the cell being lower and then block the sodium channels.
Why might LA affect cells differently?
Type of sodium channel Myelination or not Size of nerve Length of each nerve Depth of nerve fibre Distribution of Na+ and K+ channels of each nerve Inflamed nerve
What is the structure of an LA molecule?
Hydrophobic aromatic ring
Hydrophilic amine group
What are the two types of LA and where are they metabolised?
Amides - metabolised by the liver
Esters - metabolised by plasma cholinesterases
What is the only type of LA which is an ester?
Benzocaine (used in topical)
What affects the speed of action of the LA?
- Tissue pH
- pKa of anesthesia
- Diffusion distance to nerve
- Concentration of LA
- Lipid solubility
Why do we add a reducing agent to LA?
Prevent degradation of the vasoconstrictor by reducing the amount of oxygen there is to react with adrenaline
Why may some patients need to use prilocaine with felypressin?
- Patients with heart conditions
- Patients who are allergic to other LA types
Why is articaine more effective than lidocaine?
It is double the concentration
Where is articaine metabolised?
Who is this good for?
Metabolised by plasma esterases in surrounding cells (even tho it is an amine).
Good for those with liver disease where the dose needs to be reduced.
Why do we not use articaine for a block?
Higher concentration so said to increase the risk of nerve damage.
What do we use an extra short needle for?
Intra-ligamentary injection
What nerves does the mandibular nerve go into?
Lingual
Buccal
Inferior alveolar
What nerve supplies the maxilla palatal gingiva?
Nasopalatine
Anterior palatine
What supplies the buccal gingiva of the maxillary arch?
Buccal nerve 3-8 and infraorbital nerve 3-1