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40 > L9 - drugs affecting PNS > Flashcards

L9 - drugs affecting PNS Flashcards

1
Q

what is the NT at all ganglia

A

ACh

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2
Q

what is the NT in all of the PNS

A

ACh

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3
Q

what is the NT in the post ganglionic SNS

A

NA

ACh in sweat glands

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4
Q

what is the receptor at all ganglia

A

nicotinic ACh

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5
Q

what is the NT in pre ganglionic synapses

A

ACh

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6
Q

what type of receptor are nicotinic

A

ligand gated ion channels

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7
Q

what type of receptor are muscarinic

A

G protein coupled

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8
Q

where are muscarinic receptors? give examples

A

all post ganglionic PNS synapses
also sweat glands of SNS

salivary glands, GI tract, bladder, lungs , heart

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9
Q

how is ACh synthesised

A

choline + acetyl CoA via CAT enzyme

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10
Q

how does ACh get into neuron

A

carrier against conc gradient

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11
Q

where are NAChR’s located

A

NMJ and ganglionic

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12
Q

how many muscarinic receptors are there

A

M1 - M5

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13
Q

which of the Muscarinic receptors are Gq linked

A

M1 - M3 - M5

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14
Q

where are M3 found

A

smooth muscle
salivary glands
vasoconstriction

(activation increases both)

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15
Q

where are M1 found and what do they do

A

GI tract

increase GI secretion

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16
Q

what muscarinic receptors are Gi/o linked

A

M2

17
Q

what do the Gi/o linked ACh M2 receptors mediate

A

slowing of HR (atria)

neuronal inhibition

18
Q

list some effects of muscarinic agonists

A
  1. slowed HR
  2. smooth muscle contraction
  3. sweating
19
Q

what are nicotinic receptors permeable to

A

K+ Na+

20
Q

what is the difference between ACh effect at the NMJ and in the ANS

A
  1. at the ANS it causes AP at the post synaptic membrane

2. in the NMJ an end plate potential has to be reached before an AP is generated

21
Q

what types of enzymes are AChE’s

A

serine hydrolases

22
Q

what are the names of the 2 regions in the active site of AChEs

A

anionic site

esteratic site

23
Q

role of anionic site in active site of AChE’s

A

binds to choline

24
Q

is neostigmine or edrophonium longer lasting?

A

neostigmine

25
Q

effects of AChE inhibitors

A
  1. increase all PNS activity (bradycardia, salivary&GI secretions, smooth muscle contraction)

40 (20 decks)

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