general

Question 1

describe the structure of a G-protein coupled receptor

and give an example

Answer 1

single protein
sequence of 7 transmembrane domains that are a helices
extracellular N terminus
intracellular C terminus

ACh muscarinic receptor
B androgenic receptor

Question 2

describe the structure of the muscarinic ACh receptor

Answer 2

G-protein coupled receptor 
single protein 
sequence of 7 transmembrane domains that are a helices
extracellular N terminus
intracellular C terminus 
one ACh binding site

Question 3

describe the structure of the nicotinic ACh receptor

Answer 3

1. made of 5 protein subunits (can be all the same or different) that make a (non selective) ion channel (cation)
2. each subunit is made of 4 transmembrane domains that have extracellular C & N terminus
3. 2 ACh binding sites

Question 4

what relation is the muscarinic receptor to the nicotinic receptor?

Answer 4

no relation

Question 5

if a weak acid/base is at the pH of its pKa, which side will have more molecules?

Answer 5

neither, 50% would be in ‘reactant’ form and 50% in ‘product’ form
(50% acid & 50% conj base)
(50% base & 50% conj acid)

Question 6

what is the neurotransmitter in PNS

Answer 6

ACh

Question 7

what is the NT in SNS

Answer 7

ACh at ganglia, noradrenaline in tissues

ACh in in sweat glands

Question 8

what is the NT at all ganglia (1st synapse after CNS)

Answer 8

ACh acting on nicotinic receptors

Question 9

what is the only tissue where ACh acts in the SNS

Answer 9

sweat glands