L9

Question 1

LURD

Answer 1

left up; right down

Question 2

pyranose rings

Answer 2

C1 aldehyde reacts with C5 hydroxyl -> 6 membered pyranose ring

Question 3

Unbranched homopholysaccharides

Answer 3

cellulose & chitin

Question 4

Cellulose?

Answer 4

tough, water insoluble glucose polymer 
UNBRANCHED 
linked by beta-1,4-glycosidic bonds
HB
LONG FLAT

Question 5

Glycogen + starch

Answer 5

Hollow OPEN helix
Alpha-1,4
branched

Question 6

Carbohydrates are linked to proteins in 2 ways

Answer 6

1) Asparagine residues (N-glycans)
sugars linked to amide side chain of asparagine

2) Serine/threonine residues (O-glycans)
sugars linked to O in the side chain of serine/threonine residues (O-linkage)

Question 7

OLIGOSACCHARIDE ASSEMBLY

Nucleotide-monophosphate (UDP-Glc) + acceptor (carbohydrate) ->

Answer 7

(glycosyl transferase) –> monosaccharide-Acceptor + nucleotide

Question 8

Reducing sugar

Answer 8

Any sugar that can open @ anomeric C

Question 9

ABO blood group antigens are

Answer 9

glycosphingolipids on RBC

ABO encodes a glycosyltransferase

Question 10

A, B, O alleles encode

Answer 10

ACTIVE GLYCOSYLTRANSFERASE:
A: GalNAc transferase
B: Gal transferase

NO ACTIVE GLYCOSYLTRANSFERASE:
O: dead enzyme

Question 11

A& B antigens differ by

Answer 11

substitution of C2 of terminal galactose

Question 12

C-type lectins

Answer 12

Calcium binding
have 120 AA responsible for carbohydrate binding

Ca acts as a bridge between protein and sugar through direct interaction with sugar OH groups

Question 13

Selectins

Answer 13

C type lectins
Involved in cell-cell adhesion
Bind WBC to site of injury

Question 14

Influenza recognises ___ acid residues present on glycoproteins

Answer 14

sialic

Question 15

Neuraminidase

Answer 15

enables virus to be released from the cell

Question 16

Relenza

Answer 16

Anti-flu

Sialic acid analogue