L80- clinical use hormones

Question 1

Which phase of menstrual cycle varies in length and which is constant?

Answer 1

Folllicular phase varies and Luteal Phase is constant

Question 2

Mechanism of Progetserone OC?

Answer 2

thicken cervical mucus and at some levels inhibits LH surge

Question 3

How does Estrogen work in OC?

Answer 3

helps to decrease bleeding effects of Progestin (allows some buildup) and suppresses FSH ffrom anterior pituitary to lessen changes of ovulation

Question 4

OC pills effects on TEstosterone levels? Mechanism? Effects?

Answer 4

Exogenous hormones increase Sex-Binding hormone globulin which binds everything including testosterone and so less circulating testosterone

Therefore decreased libido but impoved acne

Question 5

When is emergency contraception effective and what is it?

Answer 5

high dose progesterone to inhibit LH surger and only effective if used before Ovulation

does NOT affect implantation

Question 6

Vasomotor symptoms of menopause?

Answer 6

Hot flashes

sporadic peripheral vasodilation in face and upper neck resulting from Hypothalamic Dysfunciton (narrow thermoregulatory zone) so small rise in body temp perceived as huge and get sweating etc

Question 7

What are the Hormone replacement therapeis?

Answer 7

Systemic Estrogen - tx for hot flashses

+

Progesterone - Endometrial protection needed w/ Estrogen bc of hyperplasia and cancer

vs

Vaginal estrogen which is local and dont need progesterone w/ it

Question 8

HRT makes what better and what worse?

Answer 8

HRT makes fracture risk and diabetes and mortality better

Increased Risk of Cholecystitis!!!

Question 9

Recomendations for HRT?

Answer 9

SYMPTOMATIC WOMEN - start early (more risk in older women)

use lowest effective dose

Wean within 5 years of menopause (E only within 7)

Use Progesterone w/ Estrogen