L79 - Random Qs about Hormone drugs

Question 1

How do OC pills work/ mechanism of action?

Answer 1

E - suppressed mid-cycle LH surge and ovulation

P - changes endometrium to secretory to prevent implantation AND P increases cervical mucus to block sperm

Question 2

OC use and CAncer - cancers that they cause and cancers that they reduce?

Answer 2

BENIGN LIVER TUMORS!!!! RISK

Reduced indicence of endometrial and ovarian cancer!

Question 3

What are the forms of Progesterone only OC?

Answer 3

LARC

Depoprovera

Nexplanon

Skyle

Mirena

Question 4

What are clinical uses for Progestins?

Answer 4

Endometriosis and endometrial cancer

breast cancer

Premature births - Makena

Question 5

What are estrogen uses?

Answer 5

start puberty

pregnancy

cancer treatment

used as OC

Question 6

What is Mifepristone and how does it work?

Answer 6

Binds to Progesterone receptors

Direct action on endometrium to cause shdeeding in 1-3 days (sensitizes to PG)

Inhibits GH receptors in high concentrations

Question 7

the good and the bad of HRT

Answer 7

Alleviates acute menopausal symptoms like hot flashes and prevents osteoporosis

BUT

increases risk of CVD and cancer

Question 8

What is used for infertility? / Ovulation induction?

Answer 8

Clomiphene - Anti-estrogen used to increased LH/FSH for ovulation

Question 9

What is tamoxiffen used for?

Answer 9

Treatment of ER+ BC

reduces contralateral tumors w/ fewer side efects

EStrogenic in uterus/endometrium and antiestrogenic in breast

+estrogenic in bones and CV

Question 10

Adverse effects of androgen use?

Answer 10

stimulation of “latent” prostatic neoplasm in elderly

retards growth in children and virilization of females

High Doses:

• Liver Tox
• Fluid retention –> CHF
• Renal Failure

Question 11

Endocrine therapy for prostate cancer?

Answer 11

Castration

high dose estrogens and anti-androgens

Progerstone

LHRH analogs

Question 12

Androgen Antagonists for Prostate Cancer Treatment

Answer 12

Flutamide and casodex and Abiraterone

Question 13

What classes of durgs do you use for infertility?

Answer 13

Antiestrogens and Aromatase inhibitors

Question 14

What classes of drugs do you use for Breast Cancer?

Answer 14

Antiestrogens

Aromatase inhibitors

Question 15

What do you use to treat BPH? What do you use to terat prostate cancer?

Answer 15

BPH - 5lpahreductase Finasteride

Prostate Cancer - antiandrogens and synthesisi inhibitors